Clinical, epidemiological aspects, and trends of Hepatitis B in Brazil from 2007 to 2018

Abstract Hepatitis B virus (HBV) infection is a concern for public health due to its high prevalence, high infectivity, morbidity, and mortality worldwide. Brazil presents a low HBV prevalence, but has considerable heterogeneity among its geographic regions. Here, we describe the epidemiological pro...

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Autores principales:	Cathianne Sacramento Pinto, Galileu Barbosa Costa, Ivan Bezerra Allaman, Sandra Rocha Gadelha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d41775ef932e45e0a5410ff8ead9bfe0
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spelling	oai:doaj.org-article:d41775ef932e45e0a5410ff8ead9bfe02021-12-02T15:39:50ZClinical, epidemiological aspects, and trends of Hepatitis B in Brazil from 2007 to 201810.1038/s41598-021-93434-y2045-2322https://doaj.org/article/d41775ef932e45e0a5410ff8ead9bfe02021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93434-yhttps://doaj.org/toc/2045-2322Abstract Hepatitis B virus (HBV) infection is a concern for public health due to its high prevalence, high infectivity, morbidity, and mortality worldwide. Brazil presents a low HBV prevalence, but has considerable heterogeneity among its geographic regions. Here, we describe the epidemiological profile of HBV infection in different regions of Brazil during 2007–2018, as well as the historical trends associated with the infection. We conducted an observational, ecological time-series study using secondary data collected from the National Notifiable Diseases Information System (SINAN). Our findings suggest that HBV infection was more likely to occur in young, sexually active adults. Individuals from Northeast and Midwest regions were more likely to present acute HBV infection, while individuals from South region were more likely to present chronic HBV infection, reinforcing that specific strategies are required for each particular region. Additionally, we observed a general decreasing trend of infection starting in 2014, however there was an increasing trend of infection in men and in individuals over 40 years old. Although we observed a decreasing trend in HBV infection, active surveillance is needed to prevent HBV spread and possible epidemics, as well as encouraging the vaccination of adults, especially young adult males. Our findings can inform the conduct of large-scale observational studies to evaluate clinical, economical, and social impacts of HBV infections, leading to improved social policies. Finally, our results highlight the need to improve data quality and completeness of epidemiological data, minimizing eventual errors that can make prevention and control strategies difficult.Cathianne Sacramento PintoGalileu Barbosa CostaIvan Bezerra AllamanSandra Rocha GadelhaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cathianne Sacramento Pinto Galileu Barbosa Costa Ivan Bezerra Allaman Sandra Rocha Gadelha Clinical, epidemiological aspects, and trends of Hepatitis B in Brazil from 2007 to 2018
description	Abstract Hepatitis B virus (HBV) infection is a concern for public health due to its high prevalence, high infectivity, morbidity, and mortality worldwide. Brazil presents a low HBV prevalence, but has considerable heterogeneity among its geographic regions. Here, we describe the epidemiological profile of HBV infection in different regions of Brazil during 2007–2018, as well as the historical trends associated with the infection. We conducted an observational, ecological time-series study using secondary data collected from the National Notifiable Diseases Information System (SINAN). Our findings suggest that HBV infection was more likely to occur in young, sexually active adults. Individuals from Northeast and Midwest regions were more likely to present acute HBV infection, while individuals from South region were more likely to present chronic HBV infection, reinforcing that specific strategies are required for each particular region. Additionally, we observed a general decreasing trend of infection starting in 2014, however there was an increasing trend of infection in men and in individuals over 40 years old. Although we observed a decreasing trend in HBV infection, active surveillance is needed to prevent HBV spread and possible epidemics, as well as encouraging the vaccination of adults, especially young adult males. Our findings can inform the conduct of large-scale observational studies to evaluate clinical, economical, and social impacts of HBV infections, leading to improved social policies. Finally, our results highlight the need to improve data quality and completeness of epidemiological data, minimizing eventual errors that can make prevention and control strategies difficult.
format	article
author	Cathianne Sacramento Pinto Galileu Barbosa Costa Ivan Bezerra Allaman Sandra Rocha Gadelha
author_facet	Cathianne Sacramento Pinto Galileu Barbosa Costa Ivan Bezerra Allaman Sandra Rocha Gadelha
author_sort	Cathianne Sacramento Pinto
title	Clinical, epidemiological aspects, and trends of Hepatitis B in Brazil from 2007 to 2018
title_short	Clinical, epidemiological aspects, and trends of Hepatitis B in Brazil from 2007 to 2018
title_full	Clinical, epidemiological aspects, and trends of Hepatitis B in Brazil from 2007 to 2018
title_fullStr	Clinical, epidemiological aspects, and trends of Hepatitis B in Brazil from 2007 to 2018
title_full_unstemmed	Clinical, epidemiological aspects, and trends of Hepatitis B in Brazil from 2007 to 2018
title_sort	clinical, epidemiological aspects, and trends of hepatitis b in brazil from 2007 to 2018
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d41775ef932e45e0a5410ff8ead9bfe0
work_keys_str_mv	AT cathiannesacramentopinto clinicalepidemiologicalaspectsandtrendsofhepatitisbinbrazilfrom2007to2018 AT galileubarbosacosta clinicalepidemiologicalaspectsandtrendsofhepatitisbinbrazilfrom2007to2018 AT ivanbezerraallaman clinicalepidemiologicalaspectsandtrendsofhepatitisbinbrazilfrom2007to2018 AT sandrarochagadelha clinicalepidemiologicalaspectsandtrendsofhepatitisbinbrazilfrom2007to2018
_version_	1718385901731577856

Clinical, epidemiological aspects, and trends of Hepatitis B in Brazil from 2007 to 2018

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