Prions from Sporadic Creutzfeldt-Jakob Disease Patients Propagate as Strain Mixtures

ABSTRACT Sporadic Creutzfeldt-Jakob disease (sCJD) cases are currently classified according to the methionine/valine polymorphism at codon 129 of the PRNP gene and the proteinase K-digested abnormal prion protein (PrPres) isoform identified by Western blotting (type 1 or type 2). Converging evidence...

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Bibliographic Details
Main Authors:	Hervé Cassard, Alvina Huor, Juan-Carlos Espinosa, Jean-Yves Douet, Severine Lugan, Naima Aron, Didier Vilette, Marie-Bernadette Delisle, Alba Marín-Moreno, Patrice Peran, Vincent Beringue, Juan Maria Torres, James W. Ironside, Olivier Andreoletti
Format:	article
Language:	EN
Published:	American Society for Microbiology 2020
Subjects:	prion sporadic Creutzfeldt-Jakob disease strain diversity evolution diversity prions Microbiology QR1-502
Online Access:	https://doaj.org/article/d418ac5dd0e847f99e8b5b2eafd0fb34
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Prions from Sporadic Creutzfeldt-Jakob Disease Patients Propagate as Strain Mixtures

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