Effect of extended-release niacin on hormone-sensitive lipase and lipoprotein lipase in patients with HIV-associated lipodystrophy syndrome

Dominic C Chow, Anne Tasaki, Jill Ono, Bruce Shiramizu, Scott A SouzaHawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USABackground: HIV-associated lipodystrophy syndrome is strongly associated with antiretroviral treatment in patients with human immunodeficiency virus (HIV...

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Autores principales:	Dominic C Chow, Anne Tasaki, Jill Ono, Bruce Shiramizu, Scott A Souza
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d41ebaad78044dadaeb72034f18709b8
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spelling	oai:doaj.org-article:d41ebaad78044dadaeb72034f18709b82021-12-02T07:12:37ZEffect of extended-release niacin on hormone-sensitive lipase and lipoprotein lipase in patients with HIV-associated lipodystrophy syndrome1177-54751177-5491https://doaj.org/article/d41ebaad78044dadaeb72034f18709b82008-11-01T00:00:00Zhttp://www.dovepress.com/effect-of-extended-release-niacin-on-hormone-sensitive-lipase-and-lipo-a2586https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Dominic C Chow, Anne Tasaki, Jill Ono, Bruce Shiramizu, Scott A SouzaHawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USABackground: HIV-associated lipodystrophy syndrome is strongly associated with antiretroviral treatment in patients with human immunodeficiency virus (HIV). Niacin is thought to affect hormone-sensitive lipase (HSL) and lipoprotein lipase (LPL) expression in peripheral and intra-abdominal fat (IAF).Objective: This study investigated the effect of extended-release niacin (ERN) on adipose HSL and LPL expression in patients with HIV-associated lipodystrophy syndrome.Methods: Changes in IAF and peripheral fat content and HSL and LPL expression were examined in 4 HIV-infected patients recruited from a prospective study treated with ERN. Patients underwent limited 8 slice computerized tomography abdominal scans, dual-energy X-ray absorptiometry scans, and skin punch biopsies of the mid-thigh at baseline and after 12 weeks of ERN. All subjects were on stable highly active antiretroviral therapy prior to and during the study. Changes in body habitus were self-reported.Results: Normalized HSL expression decreased in 3 patients and normalized LPL expression increased in all 4 patients when comparing pre- and post-ERN treated samples. All subjects showed a decrease in total cholesterol (TC) and triglyceride (TG) levels.Conclusions: Preliminary analysis suggests ERN may induce changes in HSL and LPL expression. This method is a feasible approach to identify changes in adipose RNA expression involved with lipolysis.Keywords: extended-release niacin, HIV, lipodystrophy syndrome, hormone-sensitive lipase (HSL), lipoprotein lipase (LPL) Dominic C ChowAnne TasakiJill OnoBruce ShiramizuScott A SouzaDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2008, Iss Issue 4, Pp 917-921 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Dominic C Chow Anne Tasaki Jill Ono Bruce Shiramizu Scott A Souza Effect of extended-release niacin on hormone-sensitive lipase and lipoprotein lipase in patients with HIV-associated lipodystrophy syndrome
description	Dominic C Chow, Anne Tasaki, Jill Ono, Bruce Shiramizu, Scott A SouzaHawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, HI, USABackground: HIV-associated lipodystrophy syndrome is strongly associated with antiretroviral treatment in patients with human immunodeficiency virus (HIV). Niacin is thought to affect hormone-sensitive lipase (HSL) and lipoprotein lipase (LPL) expression in peripheral and intra-abdominal fat (IAF).Objective: This study investigated the effect of extended-release niacin (ERN) on adipose HSL and LPL expression in patients with HIV-associated lipodystrophy syndrome.Methods: Changes in IAF and peripheral fat content and HSL and LPL expression were examined in 4 HIV-infected patients recruited from a prospective study treated with ERN. Patients underwent limited 8 slice computerized tomography abdominal scans, dual-energy X-ray absorptiometry scans, and skin punch biopsies of the mid-thigh at baseline and after 12 weeks of ERN. All subjects were on stable highly active antiretroviral therapy prior to and during the study. Changes in body habitus were self-reported.Results: Normalized HSL expression decreased in 3 patients and normalized LPL expression increased in all 4 patients when comparing pre- and post-ERN treated samples. All subjects showed a decrease in total cholesterol (TC) and triglyceride (TG) levels.Conclusions: Preliminary analysis suggests ERN may induce changes in HSL and LPL expression. This method is a feasible approach to identify changes in adipose RNA expression involved with lipolysis.Keywords: extended-release niacin, HIV, lipodystrophy syndrome, hormone-sensitive lipase (HSL), lipoprotein lipase (LPL)
format	article
author	Dominic C Chow Anne Tasaki Jill Ono Bruce Shiramizu Scott A Souza
author_facet	Dominic C Chow Anne Tasaki Jill Ono Bruce Shiramizu Scott A Souza
author_sort	Dominic C Chow
title	Effect of extended-release niacin on hormone-sensitive lipase and lipoprotein lipase in patients with HIV-associated lipodystrophy syndrome
title_short	Effect of extended-release niacin on hormone-sensitive lipase and lipoprotein lipase in patients with HIV-associated lipodystrophy syndrome
title_full	Effect of extended-release niacin on hormone-sensitive lipase and lipoprotein lipase in patients with HIV-associated lipodystrophy syndrome
title_fullStr	Effect of extended-release niacin on hormone-sensitive lipase and lipoprotein lipase in patients with HIV-associated lipodystrophy syndrome
title_full_unstemmed	Effect of extended-release niacin on hormone-sensitive lipase and lipoprotein lipase in patients with HIV-associated lipodystrophy syndrome
title_sort	effect of extended-release niacin on hormone-sensitive lipase and lipoprotein lipase in patients with hiv-associated lipodystrophy syndrome
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/d41ebaad78044dadaeb72034f18709b8
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Effect of extended-release niacin on hormone-sensitive lipase and lipoprotein lipase in patients with HIV-associated lipodystrophy syndrome

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