1-Nitropyrene exposure impairs embryo implantation through disrupting endometrial receptivity genes expression and producing excessive ROS

Haze problem is an important factor threatening human health. PM2.5 is the main culprit haze. 1-Nitropyrene (1-NP) is the main nitrated polycyclic aromatic hydrocarbon, the toxic component of PM2.5 particles. The effects of 1-NP on various organs and reproductive health have been extensively and dee...

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Autores principales:	Yuxiang Liang, Qizhi Shuai, Ying Wang, Shanshan Jin, Zihan Feng, Binghong Chen, Ting Liang, Zhizhen Liu, Hong Zhao, Zhaoyang Chen, Chunfang Wang, Jun Xie
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Haze 1-nitropyrene Embryo implantation Endometrial receptivity Reactive oxygen species Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/d41fe6f650b54cb9b514ff26c4f15c82
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spelling	oai:doaj.org-article:d41fe6f650b54cb9b514ff26c4f15c822021-11-06T04:18:42Z1-Nitropyrene exposure impairs embryo implantation through disrupting endometrial receptivity genes expression and producing excessive ROS0147-651310.1016/j.ecoenv.2021.112939https://doaj.org/article/d41fe6f650b54cb9b514ff26c4f15c822021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321010514https://doaj.org/toc/0147-6513Haze problem is an important factor threatening human health. PM2.5 is the main culprit haze. 1-Nitropyrene (1-NP) is the main nitrated polycyclic aromatic hydrocarbon, the toxic component of PM2.5 particles. The effects of 1-NP on various organs and reproductive health have been extensively and deeply studied, but the effects of 1-NP on embryo implantation and endometrial receptivity remain to be determined. The purpose of this study was to investigate the adverse effects of 1-NP on mouse embryo implantation and human endometrial receptivity. In early pregnancy, CD1 mice were given 2 mg/kg 1-NP by oral gavage, which resulted in a decreased embryo implantation number on day 5, inhibited leukemic inhibitory factor (LIF)/STAT3 pathway, decreased expression of estrogen receptor and progesterone receptor, and disrupted regulation of uterine cell proliferation. In addition, in a human in vitro implantation model, 1-NP was found to significantly inhibit the adhesion rate between trophoblast spheroids and endometrial epithelial cells, possibly by inhibiting the expression of receptivity molecules in Ishikawa cells. Promoting reactive oxygen species (ROS) production may be an additional mechanism by which it inhibits trophoblast spheroid adhesion. In this study, we used an in vivo mouse pregnancy model and an in vitro human embryo implantation model to demonstrate that 1-NP can impair endometrial receptivity and compromise embryo implantation.Yuxiang LiangQizhi ShuaiYing WangShanshan JinZihan FengBinghong ChenTing LiangZhizhen LiuHong ZhaoZhaoyang ChenChunfang WangJun XieElsevierarticleHaze1-nitropyreneEmbryo implantationEndometrial receptivityReactive oxygen speciesEnvironmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 227, Iss , Pp 112939- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Haze 1-nitropyrene Embryo implantation Endometrial receptivity Reactive oxygen species Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Haze 1-nitropyrene Embryo implantation Endometrial receptivity Reactive oxygen species Environmental pollution TD172-193.5 Environmental sciences GE1-350 Yuxiang Liang Qizhi Shuai Ying Wang Shanshan Jin Zihan Feng Binghong Chen Ting Liang Zhizhen Liu Hong Zhao Zhaoyang Chen Chunfang Wang Jun Xie 1-Nitropyrene exposure impairs embryo implantation through disrupting endometrial receptivity genes expression and producing excessive ROS
description	Haze problem is an important factor threatening human health. PM2.5 is the main culprit haze. 1-Nitropyrene (1-NP) is the main nitrated polycyclic aromatic hydrocarbon, the toxic component of PM2.5 particles. The effects of 1-NP on various organs and reproductive health have been extensively and deeply studied, but the effects of 1-NP on embryo implantation and endometrial receptivity remain to be determined. The purpose of this study was to investigate the adverse effects of 1-NP on mouse embryo implantation and human endometrial receptivity. In early pregnancy, CD1 mice were given 2 mg/kg 1-NP by oral gavage, which resulted in a decreased embryo implantation number on day 5, inhibited leukemic inhibitory factor (LIF)/STAT3 pathway, decreased expression of estrogen receptor and progesterone receptor, and disrupted regulation of uterine cell proliferation. In addition, in a human in vitro implantation model, 1-NP was found to significantly inhibit the adhesion rate between trophoblast spheroids and endometrial epithelial cells, possibly by inhibiting the expression of receptivity molecules in Ishikawa cells. Promoting reactive oxygen species (ROS) production may be an additional mechanism by which it inhibits trophoblast spheroid adhesion. In this study, we used an in vivo mouse pregnancy model and an in vitro human embryo implantation model to demonstrate that 1-NP can impair endometrial receptivity and compromise embryo implantation.
format	article
author	Yuxiang Liang Qizhi Shuai Ying Wang Shanshan Jin Zihan Feng Binghong Chen Ting Liang Zhizhen Liu Hong Zhao Zhaoyang Chen Chunfang Wang Jun Xie
author_facet	Yuxiang Liang Qizhi Shuai Ying Wang Shanshan Jin Zihan Feng Binghong Chen Ting Liang Zhizhen Liu Hong Zhao Zhaoyang Chen Chunfang Wang Jun Xie
author_sort	Yuxiang Liang
title	1-Nitropyrene exposure impairs embryo implantation through disrupting endometrial receptivity genes expression and producing excessive ROS
title_short	1-Nitropyrene exposure impairs embryo implantation through disrupting endometrial receptivity genes expression and producing excessive ROS
title_full	1-Nitropyrene exposure impairs embryo implantation through disrupting endometrial receptivity genes expression and producing excessive ROS
title_fullStr	1-Nitropyrene exposure impairs embryo implantation through disrupting endometrial receptivity genes expression and producing excessive ROS
title_full_unstemmed	1-Nitropyrene exposure impairs embryo implantation through disrupting endometrial receptivity genes expression and producing excessive ROS
title_sort	1-nitropyrene exposure impairs embryo implantation through disrupting endometrial receptivity genes expression and producing excessive ros
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d41fe6f650b54cb9b514ff26c4f15c82
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1-Nitropyrene exposure impairs embryo implantation through disrupting endometrial receptivity genes expression and producing excessive ROS

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