Systemic Inflammatory Response Syndrome and Outcomes in Ischemic Patients Treated with Endovascular Treatment

Xiangjun Xu,* Lili Yuan,* Wenbing Wang,* Junfeng Xu, Qian Yang, Yujuan Zhu, Youqing Xu, Ke Yang, Liang Ge, Xianjun Huang, Zhiming Zhou Department of Neurology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, People’s Republic of China*These authors contribute...

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Autores principales:	Xu X, Yuan L, Wang W, Xu J, Yang Q, Zhu Y, Xu Y, Yang K, Ge L, Huang X, Zhou Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	endovascular treatment outcome stroke inflammation Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/d425c674d96e4f399930478217883448
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spelling	oai:doaj.org-article:d425c674d96e4f3999304782178834482021-12-02T16:09:04ZSystemic Inflammatory Response Syndrome and Outcomes in Ischemic Patients Treated with Endovascular Treatment1178-1998https://doaj.org/article/d425c674d96e4f3999304782178834482020-12-01T00:00:00Zhttps://www.dovepress.com/systemic-inflammatory-response-syndrome-and-outcomes-in-ischemic-patie-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Xiangjun Xu,* Lili Yuan,* Wenbing Wang,* Junfeng Xu, Qian Yang, Yujuan Zhu, Youqing Xu, Ke Yang, Liang Ge, Xianjun Huang, Zhiming Zhou Department of Neurology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhiming Zhou; Xianjun HuangDepartment of Neurology, The First Affiliated Hospital of Wannan Medical College, 2# East Zheshan Road, Wuhu 241000 Anhui Province, People’s Republic of ChinaTel +86-25-80860124Fax +86-25-84664563Email neuro_depar@hotmail.com; doctorhuangxj@hotmail.comPurpose: Knowledge regarding the systemic inflammatory response syndrome (SIRS) associated with emergent large vessel occlusion (ELVO) is still insufficient. We aimed to investigate the occurrence rate, predictors, and clinical outcomes of SIRS in patients with ELVO after endovascular treatment (EVT).Patients and Methods: We retrospectively collected EVT data of patients with ELVO from July 2015 to August 2019 in our center. SIRS in the absence of infection was recorded in detail. A favorable outcome was defined as obtaining a 90-day modified Rankin Scale (mRS) score ≤ 2.Results: Among the 256 patients who received EVT, 91 (35.5%) developed SIRS. The patients who developed SIRS had a reduced favorable outcome (OR 4.112 [95% CI 1.705 to 9.920]; p=0.002) and higher mortality (OR 25.336 [95% CI 8.578 to 74.835]; p< 0.001) at 90 days. A greater SIRS burden was positively correlated with the NIHSS scores at discharge and mRS scores at 90 days (r=0.265, p=0.011; r=0.245, p=0.019). The development of SIRS was associated with neutrophilic leukocytosis, hyperglycemia, higher NIHSS scores at admission, and worse collateral circulation.Conclusion: The patients with SIRS had higher odds of poor functional outcomes and higher mortality at 90 days in the EVT-treatment setting. The severity of the inflammatory response was positively correlated with the clinical outcomes of the patients. Clinically, SIRS was associated with neutrophilic leukocytosis, hyperglycemia, baseline stroke severity, and worse collateral circulation.Keywords: endovascular treatment, outcome, stroke, inflammationXu XYuan LWang WXu JYang QZhu YXu YYang KGe LHuang XZhou ZDove Medical Pressarticleendovascular treatmentoutcomestrokeinflammationGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 2331-2340 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	endovascular treatment outcome stroke inflammation Geriatrics RC952-954.6
spellingShingle	endovascular treatment outcome stroke inflammation Geriatrics RC952-954.6 Xu X Yuan L Wang W Xu J Yang Q Zhu Y Xu Y Yang K Ge L Huang X Zhou Z Systemic Inflammatory Response Syndrome and Outcomes in Ischemic Patients Treated with Endovascular Treatment
description	Xiangjun Xu,* Lili Yuan,* Wenbing Wang,* Junfeng Xu, Qian Yang, Yujuan Zhu, Youqing Xu, Ke Yang, Liang Ge, Xianjun Huang, Zhiming Zhou Department of Neurology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhiming Zhou; Xianjun HuangDepartment of Neurology, The First Affiliated Hospital of Wannan Medical College, 2# East Zheshan Road, Wuhu 241000 Anhui Province, People’s Republic of ChinaTel +86-25-80860124Fax +86-25-84664563Email neuro_depar@hotmail.com; doctorhuangxj@hotmail.comPurpose: Knowledge regarding the systemic inflammatory response syndrome (SIRS) associated with emergent large vessel occlusion (ELVO) is still insufficient. We aimed to investigate the occurrence rate, predictors, and clinical outcomes of SIRS in patients with ELVO after endovascular treatment (EVT).Patients and Methods: We retrospectively collected EVT data of patients with ELVO from July 2015 to August 2019 in our center. SIRS in the absence of infection was recorded in detail. A favorable outcome was defined as obtaining a 90-day modified Rankin Scale (mRS) score ≤ 2.Results: Among the 256 patients who received EVT, 91 (35.5%) developed SIRS. The patients who developed SIRS had a reduced favorable outcome (OR 4.112 [95% CI 1.705 to 9.920]; p=0.002) and higher mortality (OR 25.336 [95% CI 8.578 to 74.835]; p< 0.001) at 90 days. A greater SIRS burden was positively correlated with the NIHSS scores at discharge and mRS scores at 90 days (r=0.265, p=0.011; r=0.245, p=0.019). The development of SIRS was associated with neutrophilic leukocytosis, hyperglycemia, higher NIHSS scores at admission, and worse collateral circulation.Conclusion: The patients with SIRS had higher odds of poor functional outcomes and higher mortality at 90 days in the EVT-treatment setting. The severity of the inflammatory response was positively correlated with the clinical outcomes of the patients. Clinically, SIRS was associated with neutrophilic leukocytosis, hyperglycemia, baseline stroke severity, and worse collateral circulation.Keywords: endovascular treatment, outcome, stroke, inflammation
format	article
author	Xu X Yuan L Wang W Xu J Yang Q Zhu Y Xu Y Yang K Ge L Huang X Zhou Z
author_facet	Xu X Yuan L Wang W Xu J Yang Q Zhu Y Xu Y Yang K Ge L Huang X Zhou Z
author_sort	Xu X
title	Systemic Inflammatory Response Syndrome and Outcomes in Ischemic Patients Treated with Endovascular Treatment
title_short	Systemic Inflammatory Response Syndrome and Outcomes in Ischemic Patients Treated with Endovascular Treatment
title_full	Systemic Inflammatory Response Syndrome and Outcomes in Ischemic Patients Treated with Endovascular Treatment
title_fullStr	Systemic Inflammatory Response Syndrome and Outcomes in Ischemic Patients Treated with Endovascular Treatment
title_full_unstemmed	Systemic Inflammatory Response Syndrome and Outcomes in Ischemic Patients Treated with Endovascular Treatment
title_sort	systemic inflammatory response syndrome and outcomes in ischemic patients treated with endovascular treatment
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/d425c674d96e4f399930478217883448
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Systemic Inflammatory Response Syndrome and Outcomes in Ischemic Patients Treated with Endovascular Treatment

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