Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions

The Drosophila tumour necrosis factor (TNF) system comprises a single ligand Eiger (Egr) and two receptors. The structure of Egr in complex with the extracellular domain of the receptor Grindelwald and accompanying data suggest that distinct affinities of TNF ligand for its receptors mediate non-red...

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Autores principales:	Valentina Palmerini, Silvia Monzani, Quentin Laurichesse, Rihab Loudhaief, Sara Mari, Valentina Cecatiello, Vincent Olieric, Sebastiano Pasqualato, Julien Colombani, Ditte S. Andersen, Marina Mapelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d426c051065b408e955417c443d70519
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spelling	oai:doaj.org-article:d426c051065b408e955417c443d705192021-12-02T14:21:10ZDrosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions10.1038/s41467-021-22080-92041-1723https://doaj.org/article/d426c051065b408e955417c443d705192021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22080-9https://doaj.org/toc/2041-1723The Drosophila tumour necrosis factor (TNF) system comprises a single ligand Eiger (Egr) and two receptors. The structure of Egr in complex with the extracellular domain of the receptor Grindelwald and accompanying data suggest that distinct affinities of TNF ligand for its receptors mediate non-redundant functions.Valentina PalmeriniSilvia MonzaniQuentin LaurichesseRihab LoudhaiefSara MariValentina CecatielloVincent OliericSebastiano PasqualatoJulien ColombaniDitte S. AndersenMarina MapelliNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Valentina Palmerini Silvia Monzani Quentin Laurichesse Rihab Loudhaief Sara Mari Valentina Cecatiello Vincent Olieric Sebastiano Pasqualato Julien Colombani Ditte S. Andersen Marina Mapelli Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions
description	The Drosophila tumour necrosis factor (TNF) system comprises a single ligand Eiger (Egr) and two receptors. The structure of Egr in complex with the extracellular domain of the receptor Grindelwald and accompanying data suggest that distinct affinities of TNF ligand for its receptors mediate non-redundant functions.
format	article
author	Valentina Palmerini Silvia Monzani Quentin Laurichesse Rihab Loudhaief Sara Mari Valentina Cecatiello Vincent Olieric Sebastiano Pasqualato Julien Colombani Ditte S. Andersen Marina Mapelli
author_facet	Valentina Palmerini Silvia Monzani Quentin Laurichesse Rihab Loudhaief Sara Mari Valentina Cecatiello Vincent Olieric Sebastiano Pasqualato Julien Colombani Ditte S. Andersen Marina Mapelli
author_sort	Valentina Palmerini
title	Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions
title_short	Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions
title_full	Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions
title_fullStr	Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions
title_full_unstemmed	Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions
title_sort	drosophila tnfrs grindelwald and wengen bind eiger with different affinities and promote distinct cellular functions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d426c051065b408e955417c443d70519
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Drosophila TNFRs Grindelwald and Wengen bind Eiger with different affinities and promote distinct cellular functions

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