Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study

Aberrant circulating omentin-1, which is an anti-inflammatory and pro-apoptotic adipokine, has been reported in various solid tumors. Therefore, we investigated whether or not circulating omentin-1 could be associated with postmenopausal BC (PBC) and could be used as a potential diagnostic and clini...

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Autores principales:	Gerasimos Socrates Christodoulatos, Georgios Antonakos, Irene Karampela, Sotiria Psallida, Theodora Stratigou, Natalia Vallianou, Antigoni Lekka, Ioanna Marinou, Evaggelos Vogiatzakis, Styliani Kokoris, Athanasios G. Papavassiliou, Maria Dalamaga
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	adipokine breast cancer cancer cardiometabolic risk cardiovascular disease intelectin Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/d42ae4ebb5a34f6abbe0414afa83eec6
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spelling	oai:doaj.org-article:d42ae4ebb5a34f6abbe0414afa83eec62021-11-25T16:52:47ZCirculating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study10.3390/biom111116092218-273Xhttps://doaj.org/article/d42ae4ebb5a34f6abbe0414afa83eec62021-10-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1609https://doaj.org/toc/2218-273XAberrant circulating omentin-1, which is an anti-inflammatory and pro-apoptotic adipokine, has been reported in various solid tumors. Therefore, we investigated whether or not circulating omentin-1 could be associated with postmenopausal BC (PBC) and could be used as a potential diagnostic and clinical tool taking into consideration clinicopathologic features, tumor markers, as well as anthropometric, metabolic, and inflammatory parameters. Serum omentin-1, tumor markers (CA15-3 and CEA); metabolic (insulin, glucose, HOMA index, and serum lipids), anthropometric (BMI, waist circumference, and fat mass), and inflammatory (TNF-α, IL-6, hsCRP) parameters; classic adipokines (leptin and adiponectin); the Mediterranean diet (MedDiet) score; and cardiovascular (CVD) risk were determined in 103 postmenopausal women with pathologically confirmed incident invasive BC, 103 controls matched on age, 51 patients with benign breast lesions (BBL), and 50 obese postmenopausal women of similar age. The mean serum omentin-1 was significantly lower in cases than in controls and patients with BBL (<i>p</i> < 0.001). In the patients, omentin-1 was inversely associated with tumor, metabolic and inflammatory biomarkers, cancer stage, and the number of infiltrated lymph nodes (<i>p</i> < 0.05). In all study participants, omentin-1 was negatively correlated with CVD risk and positively correlated with MedDiet score. Lower circulating omentin-1 was independently associated with PBC occurrence above and beyond known risk factors. According to the ROC curve analysis, the overall diagnostic performance of omentin-1 (0.84, 95% CI 0.79–0.89) is similar to CA15-3. Circulating omentin-1 may be a biomarker at the intersection of PBC and cardiometabolic risk in postmenopausal women, and could be modulated by the adoption of a MedDiet. Further mechanistic and large multicentric prospective and longitudinal studies are required to elucidate the ontological role of omentin-1 in BC and CVD risks, as well as its diagnostic and prognostic ability and its therapeutic potential.Gerasimos Socrates ChristodoulatosGeorgios AntonakosIrene KarampelaSotiria PsallidaTheodora StratigouNatalia VallianouAntigoni LekkaIoanna MarinouEvaggelos VogiatzakisStyliani KokorisAthanasios G. PapavassiliouMaria DalamagaMDPI AGarticleadipokinebreast cancercancercardiometabolic riskcardiovascular diseaseintelectinMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1609, p 1609 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adipokine breast cancer cancer cardiometabolic risk cardiovascular disease intelectin Microbiology QR1-502
spellingShingle	adipokine breast cancer cancer cardiometabolic risk cardiovascular disease intelectin Microbiology QR1-502 Gerasimos Socrates Christodoulatos Georgios Antonakos Irene Karampela Sotiria Psallida Theodora Stratigou Natalia Vallianou Antigoni Lekka Ioanna Marinou Evaggelos Vogiatzakis Styliani Kokoris Athanasios G. Papavassiliou Maria Dalamaga Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study
description	Aberrant circulating omentin-1, which is an anti-inflammatory and pro-apoptotic adipokine, has been reported in various solid tumors. Therefore, we investigated whether or not circulating omentin-1 could be associated with postmenopausal BC (PBC) and could be used as a potential diagnostic and clinical tool taking into consideration clinicopathologic features, tumor markers, as well as anthropometric, metabolic, and inflammatory parameters. Serum omentin-1, tumor markers (CA15-3 and CEA); metabolic (insulin, glucose, HOMA index, and serum lipids), anthropometric (BMI, waist circumference, and fat mass), and inflammatory (TNF-α, IL-6, hsCRP) parameters; classic adipokines (leptin and adiponectin); the Mediterranean diet (MedDiet) score; and cardiovascular (CVD) risk were determined in 103 postmenopausal women with pathologically confirmed incident invasive BC, 103 controls matched on age, 51 patients with benign breast lesions (BBL), and 50 obese postmenopausal women of similar age. The mean serum omentin-1 was significantly lower in cases than in controls and patients with BBL (<i>p</i> < 0.001). In the patients, omentin-1 was inversely associated with tumor, metabolic and inflammatory biomarkers, cancer stage, and the number of infiltrated lymph nodes (<i>p</i> < 0.05). In all study participants, omentin-1 was negatively correlated with CVD risk and positively correlated with MedDiet score. Lower circulating omentin-1 was independently associated with PBC occurrence above and beyond known risk factors. According to the ROC curve analysis, the overall diagnostic performance of omentin-1 (0.84, 95% CI 0.79–0.89) is similar to CA15-3. Circulating omentin-1 may be a biomarker at the intersection of PBC and cardiometabolic risk in postmenopausal women, and could be modulated by the adoption of a MedDiet. Further mechanistic and large multicentric prospective and longitudinal studies are required to elucidate the ontological role of omentin-1 in BC and CVD risks, as well as its diagnostic and prognostic ability and its therapeutic potential.
format	article
author	Gerasimos Socrates Christodoulatos Georgios Antonakos Irene Karampela Sotiria Psallida Theodora Stratigou Natalia Vallianou Antigoni Lekka Ioanna Marinou Evaggelos Vogiatzakis Styliani Kokoris Athanasios G. Papavassiliou Maria Dalamaga
author_facet	Gerasimos Socrates Christodoulatos Georgios Antonakos Irene Karampela Sotiria Psallida Theodora Stratigou Natalia Vallianou Antigoni Lekka Ioanna Marinou Evaggelos Vogiatzakis Styliani Kokoris Athanasios G. Papavassiliou Maria Dalamaga
author_sort	Gerasimos Socrates Christodoulatos
title	Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study
title_short	Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study
title_full	Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study
title_fullStr	Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study
title_full_unstemmed	Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study
title_sort	circulating omentin-1 as a biomarker at the intersection of postmenopausal breast cancer occurrence and cardiometabolic risk: an observational cross-sectional study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d42ae4ebb5a34f6abbe0414afa83eec6
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Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study

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