Association of polymorphisms in FADS gene with age-related changes in serum phospholipid polyunsaturated fatty acids and oxidative stress markers in middle-aged nonobese men

Seul Hee Hong,1,* Jung Hyun Kwak,2,* Jean Kyung Paik,3 Jey Sook Chae,2 Jong Ho Lee1,21National Research Laboratory for Clinical Nutrigenetics/Nutrigenomics, 2Research Institute of Science for Aging, Yonsei University, Seoul, South Korea; 3Department of Food and Nutrition, Eulji University, Gyeonggi-...

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Autores principales:	Hong SH, Kwak JH, Paik JK, Chae JS, Lee JH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	FADS gene age-related changes serum phospholipid polyunsaturated fatty acids oxidative stress markers nonobese men Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/d42c887faa9c419485b26723b839cdf5
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spelling	oai:doaj.org-article:d42c887faa9c419485b26723b839cdf52021-12-02T00:22:11ZAssociation of polymorphisms in FADS gene with age-related changes in serum phospholipid polyunsaturated fatty acids and oxidative stress markers in middle-aged nonobese men1178-1998https://doaj.org/article/d42c887faa9c419485b26723b839cdf52013-05-01T00:00:00Zhttps://www.dovepress.com/association-of-polymorphisms-in-fads-gene-with-age-related-changes-in--peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Seul Hee Hong,1,* Jung Hyun Kwak,2,* Jean Kyung Paik,3 Jey Sook Chae,2 Jong Ho Lee1,21National Research Laboratory for Clinical Nutrigenetics/Nutrigenomics, 2Research Institute of Science for Aging, Yonsei University, Seoul, South Korea; 3Department of Food and Nutrition, Eulji University, Gyeonggi-do, South Korea *These authors contributed equally to this workBackground: To investigate the association of FADS gene polymorphisms with age-related changes in polyunsaturated fatty acids (PUFAs) in serum phospholipids and oxidative stress markers.Methods: We genotyped 122 nonobese men aged 35–59 years without any known diseases at baseline for rs174537 near FADS1 (FEN1 rs174537G > T), FADS2 (rs174575, rs2727270), and FADS3 (rs1000778), and followed them for 3 years.Results: Among the four single-nucleotide polymorphisms, the minor variants of rs174537 and rs2727270 were significantly associated with lower concentrations of long-chain PUFAs. However, rs174537G > T showed stronger association. At baseline, men with the rs174537T allele had lower arachidonic acid (AA) and AA/linoleic acid (LA), and higher interleukin (IL)-6 levels than rs174537GG counterparts. After 3 years, rs174537GG men had significantly increased AA (P = 0.022), AA/dihomo-γ-linolenic acid (DGLA) (P = 0.007), docosapentaenoic acid (DPA), low-density lipoprotein (LDL) cholesterol, and oxidized LDL (ox-LDL), but decreased eicosatrienoic acid. The rs174537T group showed significantly increased γ-linolenic acid and ox-LDL, and decreased eicosadienoic acid, eicosapentaenoic acid (EPA)/α-linolenic acid (ALA), and IL-6. After 3 years, the rs174537T group had lower AA (P < 0.001), AA/DGLA (P = 0.019), EPA, DPA, EPA/ALA, and urinary 8-epi-prostaglandin F2α (8-epi-PGF2α) (P = 0.011) than rs174537GG. Changes in AA (P = 0.001), AA/DGLA (P = 0.017), EPA, DPA, EPA/ALA, and urinary 8-epi-PGF2α (P < 0.001) were significantly different between the groups after adjusting for baseline values. Overall, changes in AA positively correlated with changes in urinary 8-epi-PGF2α (r = 0.249, P = 0.007), plasma ox-LDL (r = 0.199, P = 0.045), and serum IL-6 (r = 0.289, P = 0.004).Conclusion: Our data show that FADS polymorphisms can affect age-associated changes in serum phospholipid long-chain PUFAs, Δ5-desaturase activity, and oxidative stress in middle-aged nonobese men. In particular, the rs174537T allele did not show the age-associated increases in AA and Δ5-desaturase activity seen with the rs174537GG genotype.Keywords: FADS gene, age-related changes, serum phospholipid polyunsaturated fatty acids, oxidative stress markers, nonobese menHong SHKwak JHPaik JKChae JSLee JHDove Medical PressarticleFADS geneage-related changesserum phospholipid polyunsaturated fatty acidsoxidative stress markersnonobese menGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 585-596 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	FADS gene age-related changes serum phospholipid polyunsaturated fatty acids oxidative stress markers nonobese men Geriatrics RC952-954.6
spellingShingle	FADS gene age-related changes serum phospholipid polyunsaturated fatty acids oxidative stress markers nonobese men Geriatrics RC952-954.6 Hong SH Kwak JH Paik JK Chae JS Lee JH Association of polymorphisms in FADS gene with age-related changes in serum phospholipid polyunsaturated fatty acids and oxidative stress markers in middle-aged nonobese men
description	Seul Hee Hong,1,* Jung Hyun Kwak,2,* Jean Kyung Paik,3 Jey Sook Chae,2 Jong Ho Lee1,21National Research Laboratory for Clinical Nutrigenetics/Nutrigenomics, 2Research Institute of Science for Aging, Yonsei University, Seoul, South Korea; 3Department of Food and Nutrition, Eulji University, Gyeonggi-do, South Korea *These authors contributed equally to this workBackground: To investigate the association of FADS gene polymorphisms with age-related changes in polyunsaturated fatty acids (PUFAs) in serum phospholipids and oxidative stress markers.Methods: We genotyped 122 nonobese men aged 35–59 years without any known diseases at baseline for rs174537 near FADS1 (FEN1 rs174537G > T), FADS2 (rs174575, rs2727270), and FADS3 (rs1000778), and followed them for 3 years.Results: Among the four single-nucleotide polymorphisms, the minor variants of rs174537 and rs2727270 were significantly associated with lower concentrations of long-chain PUFAs. However, rs174537G > T showed stronger association. At baseline, men with the rs174537T allele had lower arachidonic acid (AA) and AA/linoleic acid (LA), and higher interleukin (IL)-6 levels than rs174537GG counterparts. After 3 years, rs174537GG men had significantly increased AA (P = 0.022), AA/dihomo-γ-linolenic acid (DGLA) (P = 0.007), docosapentaenoic acid (DPA), low-density lipoprotein (LDL) cholesterol, and oxidized LDL (ox-LDL), but decreased eicosatrienoic acid. The rs174537T group showed significantly increased γ-linolenic acid and ox-LDL, and decreased eicosadienoic acid, eicosapentaenoic acid (EPA)/α-linolenic acid (ALA), and IL-6. After 3 years, the rs174537T group had lower AA (P < 0.001), AA/DGLA (P = 0.019), EPA, DPA, EPA/ALA, and urinary 8-epi-prostaglandin F2α (8-epi-PGF2α) (P = 0.011) than rs174537GG. Changes in AA (P = 0.001), AA/DGLA (P = 0.017), EPA, DPA, EPA/ALA, and urinary 8-epi-PGF2α (P < 0.001) were significantly different between the groups after adjusting for baseline values. Overall, changes in AA positively correlated with changes in urinary 8-epi-PGF2α (r = 0.249, P = 0.007), plasma ox-LDL (r = 0.199, P = 0.045), and serum IL-6 (r = 0.289, P = 0.004).Conclusion: Our data show that FADS polymorphisms can affect age-associated changes in serum phospholipid long-chain PUFAs, Δ5-desaturase activity, and oxidative stress in middle-aged nonobese men. In particular, the rs174537T allele did not show the age-associated increases in AA and Δ5-desaturase activity seen with the rs174537GG genotype.Keywords: FADS gene, age-related changes, serum phospholipid polyunsaturated fatty acids, oxidative stress markers, nonobese men
format	article
author	Hong SH Kwak JH Paik JK Chae JS Lee JH
author_facet	Hong SH Kwak JH Paik JK Chae JS Lee JH
author_sort	Hong SH
title	Association of polymorphisms in FADS gene with age-related changes in serum phospholipid polyunsaturated fatty acids and oxidative stress markers in middle-aged nonobese men
title_short	Association of polymorphisms in FADS gene with age-related changes in serum phospholipid polyunsaturated fatty acids and oxidative stress markers in middle-aged nonobese men
title_full	Association of polymorphisms in FADS gene with age-related changes in serum phospholipid polyunsaturated fatty acids and oxidative stress markers in middle-aged nonobese men
title_fullStr	Association of polymorphisms in FADS gene with age-related changes in serum phospholipid polyunsaturated fatty acids and oxidative stress markers in middle-aged nonobese men
title_full_unstemmed	Association of polymorphisms in FADS gene with age-related changes in serum phospholipid polyunsaturated fatty acids and oxidative stress markers in middle-aged nonobese men
title_sort	association of polymorphisms in fads gene with age-related changes in serum phospholipid polyunsaturated fatty acids and oxidative stress markers in middle-aged nonobese men
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/d42c887faa9c419485b26723b839cdf5
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Association of polymorphisms in FADS gene with age-related changes in serum phospholipid polyunsaturated fatty acids and oxidative stress markers in middle-aged nonobese men

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