Pentosidine and carboxymethyl-lysine associate differently with prevalent osteoporotic vertebral fracture and various bone markers

Pentosidine and carboxymethyl-lysine associate differently with prevalent osteoporotic vertebral fracture and various bone markers

Abstract Pentosidine (PEN) and carboxymethyl-lysine (CML) are well-recognized advanced glycation end products (AGEs). However, how these AGEs affect the pathophysiology of osteoporosis and osteoporotic fractures remains controversial. This cross-sectional study aimed to investigate the associations...

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Autores principales: Masaki Nakano, Yukio Nakamura, Takako Suzuki, Akiko Miyazaki, Jun Takahashi, Mitsuru Saito, Masataka Shiraki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/d432b900f4df4185a0ad6173cdb832d5
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spelling oai:doaj.org-article:d432b900f4df4185a0ad6173cdb832d52021-12-02T13:58:14ZPentosidine and carboxymethyl-lysine associate differently with prevalent osteoporotic vertebral fracture and various bone markers10.1038/s41598-020-78993-w2045-2322https://doaj.org/article/d432b900f4df4185a0ad6173cdb832d52020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78993-whttps://doaj.org/toc/2045-2322Abstract Pentosidine (PEN) and carboxymethyl-lysine (CML) are well-recognized advanced glycation end products (AGEs). However, how these AGEs affect the pathophysiology of osteoporosis and osteoporotic fractures remains controversial. This cross-sectional study aimed to investigate the associations of PEN and CML with bone markers, bone mineral density (BMD), and osteoporotic fractures in postmenopausal women from the Nagano Cohort Study. A total of 444 Japanese postmenopausal outpatients (mean ± standard deviation age: 69.8 ± 10.2 years) were enrolled after the exclusion of patients with acute or severe illness or secondary osteoporosis. The relationships among urinary PEN and serum CML levels, various bone markers, lumbar and hip BMD, and prevalent vertebral and long-bone fractures were evaluated. PEN associated significantly with prevalent vertebral fracture after adjustment for other confounders (odds ratio [OR] 1.59, 95% confidence interval [CI] 1.22–2.07; P < 0.001), but not with lumbar BMD. In contrast, a significant negative correlation was found between CML and lumbar BMD (r =  − 0.180; P < 0.001), and this relationship was significant after adjustment for confounders (OR 0.84, 95% CI 0.76–0.93; P < 0.01). Although patients with prevalent vertebral fracture had significantly higher CML levels, the association between CML and prevalent vertebral fracture did not reach significance in the multivariate regression model. Both PEN and CML may play important roles in bone health for postmenopausal women, possibly via different mechanisms.Masaki NakanoYukio NakamuraTakako SuzukiAkiko MiyazakiJun TakahashiMitsuru SaitoMasataka ShirakiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Masaki Nakano
Yukio Nakamura
Takako Suzuki
Akiko Miyazaki
Jun Takahashi
Mitsuru Saito
Masataka Shiraki
Pentosidine and carboxymethyl-lysine associate differently with prevalent osteoporotic vertebral fracture and various bone markers
description Abstract Pentosidine (PEN) and carboxymethyl-lysine (CML) are well-recognized advanced glycation end products (AGEs). However, how these AGEs affect the pathophysiology of osteoporosis and osteoporotic fractures remains controversial. This cross-sectional study aimed to investigate the associations of PEN and CML with bone markers, bone mineral density (BMD), and osteoporotic fractures in postmenopausal women from the Nagano Cohort Study. A total of 444 Japanese postmenopausal outpatients (mean ± standard deviation age: 69.8 ± 10.2 years) were enrolled after the exclusion of patients with acute or severe illness or secondary osteoporosis. The relationships among urinary PEN and serum CML levels, various bone markers, lumbar and hip BMD, and prevalent vertebral and long-bone fractures were evaluated. PEN associated significantly with prevalent vertebral fracture after adjustment for other confounders (odds ratio [OR] 1.59, 95% confidence interval [CI] 1.22–2.07; P < 0.001), but not with lumbar BMD. In contrast, a significant negative correlation was found between CML and lumbar BMD (r =  − 0.180; P < 0.001), and this relationship was significant after adjustment for confounders (OR 0.84, 95% CI 0.76–0.93; P < 0.01). Although patients with prevalent vertebral fracture had significantly higher CML levels, the association between CML and prevalent vertebral fracture did not reach significance in the multivariate regression model. Both PEN and CML may play important roles in bone health for postmenopausal women, possibly via different mechanisms.
format article
author Masaki Nakano
Yukio Nakamura
Takako Suzuki
Akiko Miyazaki
Jun Takahashi
Mitsuru Saito
Masataka Shiraki
author_facet Masaki Nakano
Yukio Nakamura
Takako Suzuki
Akiko Miyazaki
Jun Takahashi
Mitsuru Saito
Masataka Shiraki
author_sort Masaki Nakano
title Pentosidine and carboxymethyl-lysine associate differently with prevalent osteoporotic vertebral fracture and various bone markers
title_short Pentosidine and carboxymethyl-lysine associate differently with prevalent osteoporotic vertebral fracture and various bone markers
title_full Pentosidine and carboxymethyl-lysine associate differently with prevalent osteoporotic vertebral fracture and various bone markers
title_fullStr Pentosidine and carboxymethyl-lysine associate differently with prevalent osteoporotic vertebral fracture and various bone markers
title_full_unstemmed Pentosidine and carboxymethyl-lysine associate differently with prevalent osteoporotic vertebral fracture and various bone markers
title_sort pentosidine and carboxymethyl-lysine associate differently with prevalent osteoporotic vertebral fracture and various bone markers
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/d432b900f4df4185a0ad6173cdb832d5
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AT yukionakamura pentosidineandcarboxymethyllysineassociatedifferentlywithprevalentosteoporoticvertebralfractureandvariousbonemarkers
AT takakosuzuki pentosidineandcarboxymethyllysineassociatedifferentlywithprevalentosteoporoticvertebralfractureandvariousbonemarkers
AT akikomiyazaki pentosidineandcarboxymethyllysineassociatedifferentlywithprevalentosteoporoticvertebralfractureandvariousbonemarkers
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AT masatakashiraki pentosidineandcarboxymethyllysineassociatedifferentlywithprevalentosteoporoticvertebralfractureandvariousbonemarkers
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