Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01

Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA features important for other HLA-interacting molecul...

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Autores principales:	Yue Gu, Yee Hwa Wong, Chong Wai Liew, Conrad E. Z. Chan, Tanusya M. Murali, Jiawei Yap, Chien Tei Too, Kiren Purushotorman, Maryam Hamidinia, Abbas El Sahili, Angeline T. H. Goh, Rachel Z. C. Teo, Kathryn J. Wood, Brendon J. Hanson, Nicholas R. J. Gascoigne, Julien Lescar, Anantharaman Vathsala, Paul A. MacAry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d43685122a4b496da7e60656bb9c199a
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spelling	oai:doaj.org-article:d43685122a4b496da7e60656bb9c199a2021-12-02T14:40:20ZDefining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:0110.1038/s41467-019-08790-12041-1723https://doaj.org/article/d43685122a4b496da7e60656bb9c199a2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08790-1https://doaj.org/toc/2041-1723Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA features important for other HLA-interacting molecules, to enhance our understanding of alloimmunity.Yue GuYee Hwa WongChong Wai LiewConrad E. Z. ChanTanusya M. MuraliJiawei YapChien Tei TooKiren PurushotormanMaryam HamidiniaAbbas El SahiliAngeline T. H. GohRachel Z. C. TeoKathryn J. WoodBrendon J. HansonNicholas R. J. GascoigneJulien LescarAnantharaman VathsalaPaul A. MacAryNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yue Gu Yee Hwa Wong Chong Wai Liew Conrad E. Z. Chan Tanusya M. Murali Jiawei Yap Chien Tei Too Kiren Purushotorman Maryam Hamidinia Abbas El Sahili Angeline T. H. Goh Rachel Z. C. Teo Kathryn J. Wood Brendon J. Hanson Nicholas R. J. Gascoigne Julien Lescar Anantharaman Vathsala Paul A. MacAry Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01
description	Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA features important for other HLA-interacting molecules, to enhance our understanding of alloimmunity.
format	article
author	Yue Gu Yee Hwa Wong Chong Wai Liew Conrad E. Z. Chan Tanusya M. Murali Jiawei Yap Chien Tei Too Kiren Purushotorman Maryam Hamidinia Abbas El Sahili Angeline T. H. Goh Rachel Z. C. Teo Kathryn J. Wood Brendon J. Hanson Nicholas R. J. Gascoigne Julien Lescar Anantharaman Vathsala Paul A. MacAry
author_facet	Yue Gu Yee Hwa Wong Chong Wai Liew Conrad E. Z. Chan Tanusya M. Murali Jiawei Yap Chien Tei Too Kiren Purushotorman Maryam Hamidinia Abbas El Sahili Angeline T. H. Goh Rachel Z. C. Teo Kathryn J. Wood Brendon J. Hanson Nicholas R. J. Gascoigne Julien Lescar Anantharaman Vathsala Paul A. MacAry
author_sort	Yue Gu
title	Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01
title_short	Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01
title_full	Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01
title_fullStr	Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01
title_full_unstemmed	Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01
title_sort	defining the structural basis for human alloantibody binding to human leukocyte antigen allele hla-a*11:01
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d43685122a4b496da7e60656bb9c199a
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Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01

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