New Stimulation Device to Drive Multiple Transverse Intrafascicular Electrodes and Achieve Highly Selective and Rich Neural Responses

Peripheral Nerve Stimulation (PNS) is a promising approach in functional restoration following neural impairments. Although it proves to be advantageous in the number of implantation sites provided compared with intramuscular or epimysial stimulation and the fact that it does not require daily place...

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Autores principales:	Thomas Guiho, Victor Manuel López-Álvarez, Paul Čvančara, Arthur Hiairrassary, David Andreu, Thomas Stieglitz, Xavier Navarro, David Guiraud
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	stimulation selectivity stimulation device intrafascicular electrode peripheral nerve neuroprosthesis Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/d437ffaabb7d4f9e83cb60d0987fc881
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id	oai:doaj.org-article:d437ffaabb7d4f9e83cb60d0987fc881
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spelling	oai:doaj.org-article:d437ffaabb7d4f9e83cb60d0987fc8812021-11-11T19:11:55ZNew Stimulation Device to Drive Multiple Transverse Intrafascicular Electrodes and Achieve Highly Selective and Rich Neural Responses10.3390/s212172191424-8220https://doaj.org/article/d437ffaabb7d4f9e83cb60d0987fc8812021-10-01T00:00:00Zhttps://www.mdpi.com/1424-8220/21/21/7219https://doaj.org/toc/1424-8220Peripheral Nerve Stimulation (PNS) is a promising approach in functional restoration following neural impairments. Although it proves to be advantageous in the number of implantation sites provided compared with intramuscular or epimysial stimulation and the fact that it does not require daily placement, as is the case with surface electrodes, the further advancement of PNS paradigms is hampered by the limitation of spatial selectivity due to the current spread and variations of nerve physiology. New electrode designs such as the Transverse Intrafascicular Multichannel Electrode (TIME) were proposed to resolve this issue, but their use was limited by a lack of innovative multichannel stimulation devices. In this study, we introduce a new portable multichannel stimulator—called STIMEP—and implement different stimulation protocols in rats to test its versatility and unveil the potential of its combined use with TIME electrodes in rehabilitation protocols. We developed and tested various stimulation paradigms in a single fascicle and thereafter implanted two TIMEs. We also tested its stimulation using two different waveforms. The results highlighted the versatility of this new stimulation device and advocated for the parameterizing of a hyperpolarizing phase before depolarization as well as the use of small pulse widths when stimulating with multiple electrodes.Thomas GuihoVictor Manuel López-ÁlvarezPaul ČvančaraArthur HiairrassaryDavid AndreuThomas StieglitzXavier NavarroDavid GuiraudMDPI AGarticlestimulation selectivitystimulation deviceintrafascicular electrodeperipheral nerveneuroprosthesisChemical technologyTP1-1185ENSensors, Vol 21, Iss 7219, p 7219 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stimulation selectivity stimulation device intrafascicular electrode peripheral nerve neuroprosthesis Chemical technology TP1-1185
spellingShingle	stimulation selectivity stimulation device intrafascicular electrode peripheral nerve neuroprosthesis Chemical technology TP1-1185 Thomas Guiho Victor Manuel López-Álvarez Paul Čvančara Arthur Hiairrassary David Andreu Thomas Stieglitz Xavier Navarro David Guiraud New Stimulation Device to Drive Multiple Transverse Intrafascicular Electrodes and Achieve Highly Selective and Rich Neural Responses
description	Peripheral Nerve Stimulation (PNS) is a promising approach in functional restoration following neural impairments. Although it proves to be advantageous in the number of implantation sites provided compared with intramuscular or epimysial stimulation and the fact that it does not require daily placement, as is the case with surface electrodes, the further advancement of PNS paradigms is hampered by the limitation of spatial selectivity due to the current spread and variations of nerve physiology. New electrode designs such as the Transverse Intrafascicular Multichannel Electrode (TIME) were proposed to resolve this issue, but their use was limited by a lack of innovative multichannel stimulation devices. In this study, we introduce a new portable multichannel stimulator—called STIMEP—and implement different stimulation protocols in rats to test its versatility and unveil the potential of its combined use with TIME electrodes in rehabilitation protocols. We developed and tested various stimulation paradigms in a single fascicle and thereafter implanted two TIMEs. We also tested its stimulation using two different waveforms. The results highlighted the versatility of this new stimulation device and advocated for the parameterizing of a hyperpolarizing phase before depolarization as well as the use of small pulse widths when stimulating with multiple electrodes.
format	article
author	Thomas Guiho Victor Manuel López-Álvarez Paul Čvančara Arthur Hiairrassary David Andreu Thomas Stieglitz Xavier Navarro David Guiraud
author_facet	Thomas Guiho Victor Manuel López-Álvarez Paul Čvančara Arthur Hiairrassary David Andreu Thomas Stieglitz Xavier Navarro David Guiraud
author_sort	Thomas Guiho
title	New Stimulation Device to Drive Multiple Transverse Intrafascicular Electrodes and Achieve Highly Selective and Rich Neural Responses
title_short	New Stimulation Device to Drive Multiple Transverse Intrafascicular Electrodes and Achieve Highly Selective and Rich Neural Responses
title_full	New Stimulation Device to Drive Multiple Transverse Intrafascicular Electrodes and Achieve Highly Selective and Rich Neural Responses
title_fullStr	New Stimulation Device to Drive Multiple Transverse Intrafascicular Electrodes and Achieve Highly Selective and Rich Neural Responses
title_full_unstemmed	New Stimulation Device to Drive Multiple Transverse Intrafascicular Electrodes and Achieve Highly Selective and Rich Neural Responses
title_sort	new stimulation device to drive multiple transverse intrafascicular electrodes and achieve highly selective and rich neural responses
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d437ffaabb7d4f9e83cb60d0987fc881
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New Stimulation Device to Drive Multiple Transverse Intrafascicular Electrodes and Achieve Highly Selective and Rich Neural Responses

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