G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators

P2Y10 is a G-protein-coupled receptor that is expressed in CD4 T cells. Here authors show that its ligands, lysophosphatidylserine and ATP, are induced in T cells upon chemokine stimulation and regulate RhoA activation and migration through an autocrine/paracrine loop.

Guardado en:

Detalles Bibliográficos
Autores principales:	Malarvizhi Gurusamy, Denise Tischner, Jingchen Shao, Stephan Klatt, Sven Zukunft, Remy Bonnavion, Stefan Günther, Kai Siebenbrodt, Roxane-Isabelle Kestner, Tanja Kuhlmann, Ingrid Fleming, Stefan Offermanns, Nina Wettschureck
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d43888793ed74435ad7482aecc577779
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d43888793ed74435ad7482aecc577779
record_format	dspace
spelling	oai:doaj.org-article:d43888793ed74435ad7482aecc5777792021-11-28T12:32:56ZG-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators10.1038/s41467-021-26882-92041-1723https://doaj.org/article/d43888793ed74435ad7482aecc5777792021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26882-9https://doaj.org/toc/2041-1723P2Y10 is a G-protein-coupled receptor that is expressed in CD4 T cells. Here authors show that its ligands, lysophosphatidylserine and ATP, are induced in T cells upon chemokine stimulation and regulate RhoA activation and migration through an autocrine/paracrine loop.Malarvizhi GurusamyDenise TischnerJingchen ShaoStephan KlattSven ZukunftRemy BonnavionStefan GüntherKai SiebenbrodtRoxane-Isabelle KestnerTanja KuhlmannIngrid FlemingStefan OffermannsNina WettschureckNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Malarvizhi Gurusamy Denise Tischner Jingchen Shao Stephan Klatt Sven Zukunft Remy Bonnavion Stefan Günther Kai Siebenbrodt Roxane-Isabelle Kestner Tanja Kuhlmann Ingrid Fleming Stefan Offermanns Nina Wettschureck G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators
description	P2Y10 is a G-protein-coupled receptor that is expressed in CD4 T cells. Here authors show that its ligands, lysophosphatidylserine and ATP, are induced in T cells upon chemokine stimulation and regulate RhoA activation and migration through an autocrine/paracrine loop.
format	article
author	Malarvizhi Gurusamy Denise Tischner Jingchen Shao Stephan Klatt Sven Zukunft Remy Bonnavion Stefan Günther Kai Siebenbrodt Roxane-Isabelle Kestner Tanja Kuhlmann Ingrid Fleming Stefan Offermanns Nina Wettschureck
author_facet	Malarvizhi Gurusamy Denise Tischner Jingchen Shao Stephan Klatt Sven Zukunft Remy Bonnavion Stefan Günther Kai Siebenbrodt Roxane-Isabelle Kestner Tanja Kuhlmann Ingrid Fleming Stefan Offermanns Nina Wettschureck
author_sort	Malarvizhi Gurusamy
title	G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators
title_short	G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators
title_full	G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators
title_fullStr	G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators
title_full_unstemmed	G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators
title_sort	g-protein-coupled receptor p2y10 facilitates chemokine-induced cd4 t cell migration through autocrine/paracrine mediators
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d43888793ed74435ad7482aecc577779
work_keys_str_mv	AT malarvizhigurusamy gproteincoupledreceptorp2y10facilitateschemokineinducedcd4tcellmigrationthroughautocrineparacrinemediators AT denisetischner gproteincoupledreceptorp2y10facilitateschemokineinducedcd4tcellmigrationthroughautocrineparacrinemediators AT jingchenshao gproteincoupledreceptorp2y10facilitateschemokineinducedcd4tcellmigrationthroughautocrineparacrinemediators AT stephanklatt gproteincoupledreceptorp2y10facilitateschemokineinducedcd4tcellmigrationthroughautocrineparacrinemediators AT svenzukunft gproteincoupledreceptorp2y10facilitateschemokineinducedcd4tcellmigrationthroughautocrineparacrinemediators AT remybonnavion gproteincoupledreceptorp2y10facilitateschemokineinducedcd4tcellmigrationthroughautocrineparacrinemediators AT stefangunther gproteincoupledreceptorp2y10facilitateschemokineinducedcd4tcellmigrationthroughautocrineparacrinemediators AT kaisiebenbrodt gproteincoupledreceptorp2y10facilitateschemokineinducedcd4tcellmigrationthroughautocrineparacrinemediators AT roxaneisabellekestner gproteincoupledreceptorp2y10facilitateschemokineinducedcd4tcellmigrationthroughautocrineparacrinemediators AT tanjakuhlmann gproteincoupledreceptorp2y10facilitateschemokineinducedcd4tcellmigrationthroughautocrineparacrinemediators AT ingridfleming gproteincoupledreceptorp2y10facilitateschemokineinducedcd4tcellmigrationthroughautocrineparacrinemediators AT stefanoffermanns gproteincoupledreceptorp2y10facilitateschemokineinducedcd4tcellmigrationthroughautocrineparacrinemediators AT ninawettschureck gproteincoupledreceptorp2y10facilitateschemokineinducedcd4tcellmigrationthroughautocrineparacrinemediators
_version_	1718407922790170624

G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators

Ejemplares similares