The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes
GPR120 is a G-protein-coupled receptor that binds polyunsaturated fatty acids. Here, the authors show that GPR120 is upregulated in brown fat in cold-exposed mice, and mediates thermogenic activation of brown fat via a mechanism that, at least in part, depends on the release of the adipokine FGF21.
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Nature Portfolio
2016
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oai:doaj.org-article:d43c898e4b2a465d95d9fbdc8cf28cde2021-12-02T14:38:57ZThe lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes10.1038/ncomms134792041-1723https://doaj.org/article/d43c898e4b2a465d95d9fbdc8cf28cde2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13479https://doaj.org/toc/2041-1723GPR120 is a G-protein-coupled receptor that binds polyunsaturated fatty acids. Here, the authors show that GPR120 is upregulated in brown fat in cold-exposed mice, and mediates thermogenic activation of brown fat via a mechanism that, at least in part, depends on the release of the adipokine FGF21.Tania Quesada-LópezRubén CereijoJean-Valery TuratsinzeAnna PlanavilaMontserrat CairóAleix Gavaldà-NavarroMarion PeyrouRicardo MoureRoser IglesiasMarta GiraltDecio L. EizirikFrancesc VillarroyaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Tania Quesada-López Rubén Cereijo Jean-Valery Turatsinze Anna Planavila Montserrat Cairó Aleix Gavaldà-Navarro Marion Peyrou Ricardo Moure Roser Iglesias Marta Giralt Decio L. Eizirik Francesc Villarroya The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes |
| description |
GPR120 is a G-protein-coupled receptor that binds polyunsaturated fatty acids. Here, the authors show that GPR120 is upregulated in brown fat in cold-exposed mice, and mediates thermogenic activation of brown fat via a mechanism that, at least in part, depends on the release of the adipokine FGF21. |
| format |
article |
| author |
Tania Quesada-López Rubén Cereijo Jean-Valery Turatsinze Anna Planavila Montserrat Cairó Aleix Gavaldà-Navarro Marion Peyrou Ricardo Moure Roser Iglesias Marta Giralt Decio L. Eizirik Francesc Villarroya |
| author_facet |
Tania Quesada-López Rubén Cereijo Jean-Valery Turatsinze Anna Planavila Montserrat Cairó Aleix Gavaldà-Navarro Marion Peyrou Ricardo Moure Roser Iglesias Marta Giralt Decio L. Eizirik Francesc Villarroya |
| author_sort |
Tania Quesada-López |
| title |
The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes |
| title_short |
The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes |
| title_full |
The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes |
| title_fullStr |
The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes |
| title_full_unstemmed |
The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes |
| title_sort |
lipid sensor gpr120 promotes brown fat activation and fgf21 release from adipocytes |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/d43c898e4b2a465d95d9fbdc8cf28cde |
| work_keys_str_mv |
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| _version_ |
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