Innovative finding of 266-nm laser regulating CD90 levels in SDSCs

Abstract We used light to irradiate skin-derived stem cells and tried to find any cellular protein alterations 24 h after illumination. A 266-nm laser with four intensities was used, and of the nine cell markers that were surveyed in our trials, only CD90 was downregulated at an intensity of 20 μJ f...

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Autores principales:	Ray-Ling Hsiao, Yen-Chung Chen, Mei-Yue Huang, Chiang-Yun Chen, Yu-Wei Lin, Chung-Yi Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d43eb05cf88d49dd8a6615fdfa84a462
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spelling	oai:doaj.org-article:d43eb05cf88d49dd8a6615fdfa84a4622021-12-02T18:33:57ZInnovative finding of 266-nm laser regulating CD90 levels in SDSCs10.1038/s41598-021-93508-x2045-2322https://doaj.org/article/d43eb05cf88d49dd8a6615fdfa84a4622021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93508-xhttps://doaj.org/toc/2045-2322Abstract We used light to irradiate skin-derived stem cells and tried to find any cellular protein alterations 24 h after illumination. A 266-nm laser with four intensities was used, and of the nine cell markers that were surveyed in our trials, only CD90 was downregulated at an intensity of 20 μJ for 10 s. Repeated illuminations from the 266-nm laser at seven intensities revealed that CD90 expression was downregulated 14.6–28.8%, depending on light intensity. The maximal effect was noted at an intensity of 30 μJ for 2 s. This innovative finding reveals that a 266-nm laser can regulate protein expression in skin-derivative stem cells.Ray-Ling HsiaoYen-Chung ChenMei-Yue HuangChiang-Yun ChenYu-Wei LinChung-Yi WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ray-Ling Hsiao Yen-Chung Chen Mei-Yue Huang Chiang-Yun Chen Yu-Wei Lin Chung-Yi Wu Innovative finding of 266-nm laser regulating CD90 levels in SDSCs
description	Abstract We used light to irradiate skin-derived stem cells and tried to find any cellular protein alterations 24 h after illumination. A 266-nm laser with four intensities was used, and of the nine cell markers that were surveyed in our trials, only CD90 was downregulated at an intensity of 20 μJ for 10 s. Repeated illuminations from the 266-nm laser at seven intensities revealed that CD90 expression was downregulated 14.6–28.8%, depending on light intensity. The maximal effect was noted at an intensity of 30 μJ for 2 s. This innovative finding reveals that a 266-nm laser can regulate protein expression in skin-derivative stem cells.
format	article
author	Ray-Ling Hsiao Yen-Chung Chen Mei-Yue Huang Chiang-Yun Chen Yu-Wei Lin Chung-Yi Wu
author_facet	Ray-Ling Hsiao Yen-Chung Chen Mei-Yue Huang Chiang-Yun Chen Yu-Wei Lin Chung-Yi Wu
author_sort	Ray-Ling Hsiao
title	Innovative finding of 266-nm laser regulating CD90 levels in SDSCs
title_short	Innovative finding of 266-nm laser regulating CD90 levels in SDSCs
title_full	Innovative finding of 266-nm laser regulating CD90 levels in SDSCs
title_fullStr	Innovative finding of 266-nm laser regulating CD90 levels in SDSCs
title_full_unstemmed	Innovative finding of 266-nm laser regulating CD90 levels in SDSCs
title_sort	innovative finding of 266-nm laser regulating cd90 levels in sdscs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d43eb05cf88d49dd8a6615fdfa84a462
work_keys_str_mv	AT raylinghsiao innovativefindingof266nmlaserregulatingcd90levelsinsdscs AT yenchungchen innovativefindingof266nmlaserregulatingcd90levelsinsdscs AT meiyuehuang innovativefindingof266nmlaserregulatingcd90levelsinsdscs AT chiangyunchen innovativefindingof266nmlaserregulatingcd90levelsinsdscs AT yuweilin innovativefindingof266nmlaserregulatingcd90levelsinsdscs AT chungyiwu innovativefindingof266nmlaserregulatingcd90levelsinsdscs
_version_	1718377948995649536

Innovative finding of 266-nm laser regulating CD90 levels in SDSCs

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