40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling

Following the termination of translation at stop codons, the eukaryotic 60S subunit of the ribosome is removed by the ATPase ABCE1. Here using 40S ribosome footprinting the authors provide a direct demonstration that the yeast orthologs of eIF2D, MCT-1, and DENR recycle the 40S subunits.

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Autores principales:	David J. Young, Sezen Meydan, Nicholas R. Guydosh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d43ef642392a4e1f9d286a8a5e155f96
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spelling	oai:doaj.org-article:d43ef642392a4e1f9d286a8a5e155f962021-12-02T15:52:23Z40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling10.1038/s41467-021-23223-82041-1723https://doaj.org/article/d43ef642392a4e1f9d286a8a5e155f962021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23223-8https://doaj.org/toc/2041-1723Following the termination of translation at stop codons, the eukaryotic 60S subunit of the ribosome is removed by the ATPase ABCE1. Here using 40S ribosome footprinting the authors provide a direct demonstration that the yeast orthologs of eIF2D, MCT-1, and DENR recycle the 40S subunits.David J. YoungSezen MeydanNicholas R. GuydoshNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David J. Young Sezen Meydan Nicholas R. Guydosh 40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling
description	Following the termination of translation at stop codons, the eukaryotic 60S subunit of the ribosome is removed by the ATPase ABCE1. Here using 40S ribosome footprinting the authors provide a direct demonstration that the yeast orthologs of eIF2D, MCT-1, and DENR recycle the 40S subunits.
format	article
author	David J. Young Sezen Meydan Nicholas R. Guydosh
author_facet	David J. Young Sezen Meydan Nicholas R. Guydosh
author_sort	David J. Young
title	40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling
title_short	40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling
title_full	40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling
title_fullStr	40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling
title_full_unstemmed	40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling
title_sort	40s ribosome profiling reveals distinct roles for tma20/tma22 (mct-1/denr) and tma64 (eif2d) in 40s subunit recycling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d43ef642392a4e1f9d286a8a5e155f96
work_keys_str_mv	AT davidjyoung 40sribosomeprofilingrevealsdistinctrolesfortma20tma22mct1denrandtma64eif2din40ssubunitrecycling AT sezenmeydan 40sribosomeprofilingrevealsdistinctrolesfortma20tma22mct1denrandtma64eif2din40ssubunitrecycling AT nicholasrguydosh 40sribosomeprofilingrevealsdistinctrolesfortma20tma22mct1denrandtma64eif2din40ssubunitrecycling
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40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling

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