Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis

Abstract Cancer patients with Tissue Factor (TF)-bearing MPs have been presented association with increased risk of venous thromboembolism (VTE), but results of these studies have not been consistent. We aimed to conduct a meta-analysis to assess the relationship between TF-bearing MPs and risk of V...

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Autores principales: Chan-juan Cui, Guo-jing Wang, Shuo Yang, Sheng-kai Huang, Rui Qiao, Wei Cui
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d441804c9f664133b52e64e140f7b89c
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spelling oai:doaj.org-article:d441804c9f664133b52e64e140f7b89c2021-12-02T15:08:56ZTissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis10.1038/s41598-018-19889-82045-2322https://doaj.org/article/d441804c9f664133b52e64e140f7b89c2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19889-8https://doaj.org/toc/2045-2322Abstract Cancer patients with Tissue Factor (TF)-bearing MPs have been presented association with increased risk of venous thromboembolism (VTE), but results of these studies have not been consistent. We aimed to conduct a meta-analysis to assess the relationship between TF-bearing MPs and risk of VTE in patients with cancer. PubMed, Web of Science and EMBASE Databases were systematically retrieved up to1th June 2017. Two case-control studies and four cohort studies met the entry requirements in this analysis. The summary odd ratio (OR) were estimated by a random effect model. The overall OR was 1.76 (95% CI: 1.21–2.56, I2 = 62.0%). The OR of case-control studies was 3.41 (95% CI: 1.45–8.02, I2 = 0.0%) and that of cohort studies was1.53 (95% CI: 1.05–2.24, I2 = 66.1%). The association between TF-bearing MPs and the risk of VTE in cancer patients was found in this meta-analysis. Publication bias testing and sensitivity subgroup analysis suggested that results of this meta-analysis were robustness. In conclusion, TF-bearing MPs were associated with increased risk of VTE in patients with cancer. Whereas, more well-designed studies and more comprehensive adjustments for confounders in further studies are warranted to affirm the association.Chan-juan CuiGuo-jing WangShuo YangSheng-kai HuangRui QiaoWei CuiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Chan-juan Cui
Guo-jing Wang
Shuo Yang
Sheng-kai Huang
Rui Qiao
Wei Cui
Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis
description Abstract Cancer patients with Tissue Factor (TF)-bearing MPs have been presented association with increased risk of venous thromboembolism (VTE), but results of these studies have not been consistent. We aimed to conduct a meta-analysis to assess the relationship between TF-bearing MPs and risk of VTE in patients with cancer. PubMed, Web of Science and EMBASE Databases were systematically retrieved up to1th June 2017. Two case-control studies and four cohort studies met the entry requirements in this analysis. The summary odd ratio (OR) were estimated by a random effect model. The overall OR was 1.76 (95% CI: 1.21–2.56, I2 = 62.0%). The OR of case-control studies was 3.41 (95% CI: 1.45–8.02, I2 = 0.0%) and that of cohort studies was1.53 (95% CI: 1.05–2.24, I2 = 66.1%). The association between TF-bearing MPs and the risk of VTE in cancer patients was found in this meta-analysis. Publication bias testing and sensitivity subgroup analysis suggested that results of this meta-analysis were robustness. In conclusion, TF-bearing MPs were associated with increased risk of VTE in patients with cancer. Whereas, more well-designed studies and more comprehensive adjustments for confounders in further studies are warranted to affirm the association.
format article
author Chan-juan Cui
Guo-jing Wang
Shuo Yang
Sheng-kai Huang
Rui Qiao
Wei Cui
author_facet Chan-juan Cui
Guo-jing Wang
Shuo Yang
Sheng-kai Huang
Rui Qiao
Wei Cui
author_sort Chan-juan Cui
title Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis
title_short Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis
title_full Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis
title_fullStr Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis
title_full_unstemmed Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis
title_sort tissue factor-bearing mps and the risk of venous thrombosis in cancer patients: a meta-analysis
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/d441804c9f664133b52e64e140f7b89c
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