Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis
Abstract Cancer patients with Tissue Factor (TF)-bearing MPs have been presented association with increased risk of venous thromboembolism (VTE), but results of these studies have not been consistent. We aimed to conduct a meta-analysis to assess the relationship between TF-bearing MPs and risk of V...
Guardado en:
Autores principales: | , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/d441804c9f664133b52e64e140f7b89c |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:d441804c9f664133b52e64e140f7b89c |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:d441804c9f664133b52e64e140f7b89c2021-12-02T15:08:56ZTissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis10.1038/s41598-018-19889-82045-2322https://doaj.org/article/d441804c9f664133b52e64e140f7b89c2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-19889-8https://doaj.org/toc/2045-2322Abstract Cancer patients with Tissue Factor (TF)-bearing MPs have been presented association with increased risk of venous thromboembolism (VTE), but results of these studies have not been consistent. We aimed to conduct a meta-analysis to assess the relationship between TF-bearing MPs and risk of VTE in patients with cancer. PubMed, Web of Science and EMBASE Databases were systematically retrieved up to1th June 2017. Two case-control studies and four cohort studies met the entry requirements in this analysis. The summary odd ratio (OR) were estimated by a random effect model. The overall OR was 1.76 (95% CI: 1.21–2.56, I2 = 62.0%). The OR of case-control studies was 3.41 (95% CI: 1.45–8.02, I2 = 0.0%) and that of cohort studies was1.53 (95% CI: 1.05–2.24, I2 = 66.1%). The association between TF-bearing MPs and the risk of VTE in cancer patients was found in this meta-analysis. Publication bias testing and sensitivity subgroup analysis suggested that results of this meta-analysis were robustness. In conclusion, TF-bearing MPs were associated with increased risk of VTE in patients with cancer. Whereas, more well-designed studies and more comprehensive adjustments for confounders in further studies are warranted to affirm the association.Chan-juan CuiGuo-jing WangShuo YangSheng-kai HuangRui QiaoWei CuiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Chan-juan Cui Guo-jing Wang Shuo Yang Sheng-kai Huang Rui Qiao Wei Cui Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis |
description |
Abstract Cancer patients with Tissue Factor (TF)-bearing MPs have been presented association with increased risk of venous thromboembolism (VTE), but results of these studies have not been consistent. We aimed to conduct a meta-analysis to assess the relationship between TF-bearing MPs and risk of VTE in patients with cancer. PubMed, Web of Science and EMBASE Databases were systematically retrieved up to1th June 2017. Two case-control studies and four cohort studies met the entry requirements in this analysis. The summary odd ratio (OR) were estimated by a random effect model. The overall OR was 1.76 (95% CI: 1.21–2.56, I2 = 62.0%). The OR of case-control studies was 3.41 (95% CI: 1.45–8.02, I2 = 0.0%) and that of cohort studies was1.53 (95% CI: 1.05–2.24, I2 = 66.1%). The association between TF-bearing MPs and the risk of VTE in cancer patients was found in this meta-analysis. Publication bias testing and sensitivity subgroup analysis suggested that results of this meta-analysis were robustness. In conclusion, TF-bearing MPs were associated with increased risk of VTE in patients with cancer. Whereas, more well-designed studies and more comprehensive adjustments for confounders in further studies are warranted to affirm the association. |
format |
article |
author |
Chan-juan Cui Guo-jing Wang Shuo Yang Sheng-kai Huang Rui Qiao Wei Cui |
author_facet |
Chan-juan Cui Guo-jing Wang Shuo Yang Sheng-kai Huang Rui Qiao Wei Cui |
author_sort |
Chan-juan Cui |
title |
Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis |
title_short |
Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis |
title_full |
Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis |
title_fullStr |
Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis |
title_full_unstemmed |
Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis |
title_sort |
tissue factor-bearing mps and the risk of venous thrombosis in cancer patients: a meta-analysis |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/d441804c9f664133b52e64e140f7b89c |
work_keys_str_mv |
AT chanjuancui tissuefactorbearingmpsandtheriskofvenousthrombosisincancerpatientsametaanalysis AT guojingwang tissuefactorbearingmpsandtheriskofvenousthrombosisincancerpatientsametaanalysis AT shuoyang tissuefactorbearingmpsandtheriskofvenousthrombosisincancerpatientsametaanalysis AT shengkaihuang tissuefactorbearingmpsandtheriskofvenousthrombosisincancerpatientsametaanalysis AT ruiqiao tissuefactorbearingmpsandtheriskofvenousthrombosisincancerpatientsametaanalysis AT weicui tissuefactorbearingmpsandtheriskofvenousthrombosisincancerpatientsametaanalysis |
_version_ |
1718387968483262464 |