Microfluidic-based processors and circuits design

Abstract Droplets produced within microfluidics have not only attracted the attention of researchers to develop complex biological, industrial and clinical testing systems but also played a role as a bit of data. The flow of droplets within a network of microfluidic channels by stimulation of their...

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Autores principales:	Kasra Azizbeigi, Maysam Zamani Pedram, Amir Sanati-Nezhad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d4418edda66f4e80ac905aa5ea8300ff
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spelling	oai:doaj.org-article:d4418edda66f4e80ac905aa5ea8300ff2021-12-02T15:00:59ZMicrofluidic-based processors and circuits design10.1038/s41598-021-90485-z2045-2322https://doaj.org/article/d4418edda66f4e80ac905aa5ea8300ff2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90485-zhttps://doaj.org/toc/2045-2322Abstract Droplets produced within microfluidics have not only attracted the attention of researchers to develop complex biological, industrial and clinical testing systems but also played a role as a bit of data. The flow of droplets within a network of microfluidic channels by stimulation of their movements, trajectories, and interaction timing, can provide an opportunity for preparation of complex and logical microfluidic circuits. Such mechanical-based circuits open up avenues to mimic the logic of electrical circuits within microfluidics. Recently, simple microfluidic-based logical elements such as AND, OR, and NOT gates have been experimentally developed and tested to model basic logic conditions in laboratory settings. In this work, we develop new microfluidic networks, control the shape of channels and speed of droplet movement, and regulate the size of bubbles in order to extend the logical elements to six new logic gates, including AND/OR type 1, AND/OR type 2, NOT type 1, NOT type 2, Flip-Flop, Synchronizer, and a parametric model of T-junction as a bubble generator. We further designed and simulated a novel microfluidic Decoder 1 to 2, a Decoder 2 to 4, and a microfluidic circuit that combines several individual logic gates into one complex circuit. Further fabrication and experimental testing of these newly introduced logic gates within microfluidics enable implementing complex circuits in high-throughput microfluidic platforms for tissue engineering, drug testing and development, and chemical synthesis and process design.Kasra AzizbeigiMaysam Zamani PedramAmir Sanati-NezhadNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kasra Azizbeigi Maysam Zamani Pedram Amir Sanati-Nezhad Microfluidic-based processors and circuits design
description	Abstract Droplets produced within microfluidics have not only attracted the attention of researchers to develop complex biological, industrial and clinical testing systems but also played a role as a bit of data. The flow of droplets within a network of microfluidic channels by stimulation of their movements, trajectories, and interaction timing, can provide an opportunity for preparation of complex and logical microfluidic circuits. Such mechanical-based circuits open up avenues to mimic the logic of electrical circuits within microfluidics. Recently, simple microfluidic-based logical elements such as AND, OR, and NOT gates have been experimentally developed and tested to model basic logic conditions in laboratory settings. In this work, we develop new microfluidic networks, control the shape of channels and speed of droplet movement, and regulate the size of bubbles in order to extend the logical elements to six new logic gates, including AND/OR type 1, AND/OR type 2, NOT type 1, NOT type 2, Flip-Flop, Synchronizer, and a parametric model of T-junction as a bubble generator. We further designed and simulated a novel microfluidic Decoder 1 to 2, a Decoder 2 to 4, and a microfluidic circuit that combines several individual logic gates into one complex circuit. Further fabrication and experimental testing of these newly introduced logic gates within microfluidics enable implementing complex circuits in high-throughput microfluidic platforms for tissue engineering, drug testing and development, and chemical synthesis and process design.
format	article
author	Kasra Azizbeigi Maysam Zamani Pedram Amir Sanati-Nezhad
author_facet	Kasra Azizbeigi Maysam Zamani Pedram Amir Sanati-Nezhad
author_sort	Kasra Azizbeigi
title	Microfluidic-based processors and circuits design
title_short	Microfluidic-based processors and circuits design
title_full	Microfluidic-based processors and circuits design
title_fullStr	Microfluidic-based processors and circuits design
title_full_unstemmed	Microfluidic-based processors and circuits design
title_sort	microfluidic-based processors and circuits design
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d4418edda66f4e80ac905aa5ea8300ff
work_keys_str_mv	AT kasraazizbeigi microfluidicbasedprocessorsandcircuitsdesign AT maysamzamanipedram microfluidicbasedprocessorsandcircuitsdesign AT amirsanatinezhad microfluidicbasedprocessorsandcircuitsdesign
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Microfluidic-based processors and circuits design

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