The identification of pathway markers in intracranial aneurysm using genome-wide association data from two different populations.

The identification of significant individual factors causing complex diseases is challenging in genome-wide association studies (GWAS) since each factor has only a modest effect on the disease development mechanism. In this study, we hypothesize that the biological pathways that are targeted by thes...

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Autores principales:	Burcu Bakir-Gungor, Osman Ugur Sezerman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d444484ea13f4d8d8f32f523e16ff534
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spelling	oai:doaj.org-article:d444484ea13f4d8d8f32f523e16ff5342021-11-18T07:54:43ZThe identification of pathway markers in intracranial aneurysm using genome-wide association data from two different populations.1932-620310.1371/journal.pone.0057022https://doaj.org/article/d444484ea13f4d8d8f32f523e16ff5342013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23483893/?tool=EBIhttps://doaj.org/toc/1932-6203The identification of significant individual factors causing complex diseases is challenging in genome-wide association studies (GWAS) since each factor has only a modest effect on the disease development mechanism. In this study, we hypothesize that the biological pathways that are targeted by these individual factors show higher conservation within and across populations. To test this hypothesis, we searched for the disease related pathways on two intracranial aneurysm GWAS in European and Japanese case-control cohorts. Even though there were a few significantly conserved SNPs within and between populations, seven of the top ten affected pathways were found significant in both populations. The probability of random occurrence of such an event is 2.44E-36. We therefore claim that even though each individual has a unique combination of factors involved in the mechanism of disease development, most targeted pathways that need to be altered by these factors are, for the most part, the same. These pathways can serve as disease markers. Individuals, for example, can be scanned for factors affecting the genes in marker pathways. Hence, individual factors of disease development can be determined; and this knowledge can be exploited for drug development and personalized therapeutic applications. Here, we discuss the potential avenues of pathway markers in medicine and their translation to preventive and individualized health care.Burcu Bakir-GungorOsman Ugur SezermanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e57022 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Burcu Bakir-Gungor Osman Ugur Sezerman The identification of pathway markers in intracranial aneurysm using genome-wide association data from two different populations.
description	The identification of significant individual factors causing complex diseases is challenging in genome-wide association studies (GWAS) since each factor has only a modest effect on the disease development mechanism. In this study, we hypothesize that the biological pathways that are targeted by these individual factors show higher conservation within and across populations. To test this hypothesis, we searched for the disease related pathways on two intracranial aneurysm GWAS in European and Japanese case-control cohorts. Even though there were a few significantly conserved SNPs within and between populations, seven of the top ten affected pathways were found significant in both populations. The probability of random occurrence of such an event is 2.44E-36. We therefore claim that even though each individual has a unique combination of factors involved in the mechanism of disease development, most targeted pathways that need to be altered by these factors are, for the most part, the same. These pathways can serve as disease markers. Individuals, for example, can be scanned for factors affecting the genes in marker pathways. Hence, individual factors of disease development can be determined; and this knowledge can be exploited for drug development and personalized therapeutic applications. Here, we discuss the potential avenues of pathway markers in medicine and their translation to preventive and individualized health care.
format	article
author	Burcu Bakir-Gungor Osman Ugur Sezerman
author_facet	Burcu Bakir-Gungor Osman Ugur Sezerman
author_sort	Burcu Bakir-Gungor
title	The identification of pathway markers in intracranial aneurysm using genome-wide association data from two different populations.
title_short	The identification of pathway markers in intracranial aneurysm using genome-wide association data from two different populations.
title_full	The identification of pathway markers in intracranial aneurysm using genome-wide association data from two different populations.
title_fullStr	The identification of pathway markers in intracranial aneurysm using genome-wide association data from two different populations.
title_full_unstemmed	The identification of pathway markers in intracranial aneurysm using genome-wide association data from two different populations.
title_sort	identification of pathway markers in intracranial aneurysm using genome-wide association data from two different populations.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/d444484ea13f4d8d8f32f523e16ff534
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The identification of pathway markers in intracranial aneurysm using genome-wide association data from two different populations.

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