Satellite glial cells promote regenerative growth in sensory neurons

The contribution of satellite glia to peripheral nerve regeneration is unclear. Here, the authors show that satellite glia are transcriptionally distinct from Schwann cells, share similarities with astrocytes, and, upon injury, they contribute to axon regeneration via Fasn-PPARα signalling pathway.

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Autores principales:	Oshri Avraham, Pan-Yue Deng, Sara Jones, Rejji Kuruvilla, Clay F. Semenkovich, Vitaly A. Klyachko, Valeria Cavalli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d446500304ea4ebe9944be716f685078
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spelling	oai:doaj.org-article:d446500304ea4ebe9944be716f6850782021-12-02T18:51:09ZSatellite glial cells promote regenerative growth in sensory neurons10.1038/s41467-020-18642-y2041-1723https://doaj.org/article/d446500304ea4ebe9944be716f6850782020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18642-yhttps://doaj.org/toc/2041-1723The contribution of satellite glia to peripheral nerve regeneration is unclear. Here, the authors show that satellite glia are transcriptionally distinct from Schwann cells, share similarities with astrocytes, and, upon injury, they contribute to axon regeneration via Fasn-PPARα signalling pathway.Oshri AvrahamPan-Yue DengSara JonesRejji KuruvillaClay F. SemenkovichVitaly A. KlyachkoValeria CavalliNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Oshri Avraham Pan-Yue Deng Sara Jones Rejji Kuruvilla Clay F. Semenkovich Vitaly A. Klyachko Valeria Cavalli Satellite glial cells promote regenerative growth in sensory neurons
description	The contribution of satellite glia to peripheral nerve regeneration is unclear. Here, the authors show that satellite glia are transcriptionally distinct from Schwann cells, share similarities with astrocytes, and, upon injury, they contribute to axon regeneration via Fasn-PPARα signalling pathway.
format	article
author	Oshri Avraham Pan-Yue Deng Sara Jones Rejji Kuruvilla Clay F. Semenkovich Vitaly A. Klyachko Valeria Cavalli
author_facet	Oshri Avraham Pan-Yue Deng Sara Jones Rejji Kuruvilla Clay F. Semenkovich Vitaly A. Klyachko Valeria Cavalli
author_sort	Oshri Avraham
title	Satellite glial cells promote regenerative growth in sensory neurons
title_short	Satellite glial cells promote regenerative growth in sensory neurons
title_full	Satellite glial cells promote regenerative growth in sensory neurons
title_fullStr	Satellite glial cells promote regenerative growth in sensory neurons
title_full_unstemmed	Satellite glial cells promote regenerative growth in sensory neurons
title_sort	satellite glial cells promote regenerative growth in sensory neurons
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d446500304ea4ebe9944be716f685078
work_keys_str_mv	AT oshriavraham satelliteglialcellspromoteregenerativegrowthinsensoryneurons AT panyuedeng satelliteglialcellspromoteregenerativegrowthinsensoryneurons AT sarajones satelliteglialcellspromoteregenerativegrowthinsensoryneurons AT rejjikuruvilla satelliteglialcellspromoteregenerativegrowthinsensoryneurons AT clayfsemenkovich satelliteglialcellspromoteregenerativegrowthinsensoryneurons AT vitalyaklyachko satelliteglialcellspromoteregenerativegrowthinsensoryneurons AT valeriacavalli satelliteglialcellspromoteregenerativegrowthinsensoryneurons
_version_	1718377473157103616

Satellite glial cells promote regenerative growth in sensory neurons

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