Real-Time Neuropsychological Testing Protocol for Left Temporal Brain Tumor Surgery: A Technical Note and Case Report

Background: The risk of surgery in eloquent areas is related to neuropsychological dysfunctions. Maximizing the extent of resection increases the overall survival. The onco-functional balance is mandatory when surgery involves cognitive areas, and maximal information on the cognitive status of patie...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Barbara Tomasino, Ilaria Guarracino, Tamara Ius, Marta Maieron, Miran Skrap
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	awake surgery brain mapping glioma neuropsychology plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/d4471ca2f95e47dfa96de7da37b7bf7b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d4471ca2f95e47dfa96de7da37b7bf7b
record_format	dspace
spelling	oai:doaj.org-article:d4471ca2f95e47dfa96de7da37b7bf7b2021-12-03T05:40:18ZReal-Time Neuropsychological Testing Protocol for Left Temporal Brain Tumor Surgery: A Technical Note and Case Report1662-516110.3389/fnhum.2021.760569https://doaj.org/article/d4471ca2f95e47dfa96de7da37b7bf7b2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnhum.2021.760569/fullhttps://doaj.org/toc/1662-5161Background: The risk of surgery in eloquent areas is related to neuropsychological dysfunctions. Maximizing the extent of resection increases the overall survival. The onco-functional balance is mandatory when surgery involves cognitive areas, and maximal information on the cognitive status of patients during awake surgery is needed. This can be achieved using direct cortical stimulation mapping and, in addition to this, a neuropsychological monitoring technique called real-time neuropsychological testing (RTNT). The RTNT includes testing protocols based on the area where the surgery is performed. We reported on tests used for left temporal lobe surgery and our RTNT decision tree.Case Report: We reported our RTNT experience with a 25-year-old right-handed man with 13 years of schooling. He reported daily partial seizures. MRI revealed the presence of a low-grade glioma involving the temporo-insular cortex. The neuropsychological status presurgery which was within the normal range was combined with functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) information. Awake surgery plus RTNT was performed. Direct electrical stimulation during object naming elicited a motor speech arrest. Resection was continuously accompanied by the RTNT. The RTNT provided enriched information to the surgeon. Performance never dropped. A slight decrement in accuracy emerged for pseudoword repetition, short-term memory and working memory, phonological processing, and verbal comprehension. Total resection was performed, and the histological examination confirmed the nature of the lesion. Immediate postsurgery performance was within the normal range as it was the fMRI and DTI assessment.Conclusion: The RTNT provides essential information that can be used online, during surgery, for clinical aims to provide the surgeon with useful feedback on the cognitive status of patients.Barbara TomasinoIlaria GuarracinoTamara IusMarta MaieronMiran SkrapFrontiers Media S.A.articleawake surgerybrain mappinggliomaneuropsychologyplasticityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Human Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	awake surgery brain mapping glioma neuropsychology plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	awake surgery brain mapping glioma neuropsychology plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Barbara Tomasino Ilaria Guarracino Tamara Ius Marta Maieron Miran Skrap Real-Time Neuropsychological Testing Protocol for Left Temporal Brain Tumor Surgery: A Technical Note and Case Report
description	Background: The risk of surgery in eloquent areas is related to neuropsychological dysfunctions. Maximizing the extent of resection increases the overall survival. The onco-functional balance is mandatory when surgery involves cognitive areas, and maximal information on the cognitive status of patients during awake surgery is needed. This can be achieved using direct cortical stimulation mapping and, in addition to this, a neuropsychological monitoring technique called real-time neuropsychological testing (RTNT). The RTNT includes testing protocols based on the area where the surgery is performed. We reported on tests used for left temporal lobe surgery and our RTNT decision tree.Case Report: We reported our RTNT experience with a 25-year-old right-handed man with 13 years of schooling. He reported daily partial seizures. MRI revealed the presence of a low-grade glioma involving the temporo-insular cortex. The neuropsychological status presurgery which was within the normal range was combined with functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) information. Awake surgery plus RTNT was performed. Direct electrical stimulation during object naming elicited a motor speech arrest. Resection was continuously accompanied by the RTNT. The RTNT provided enriched information to the surgeon. Performance never dropped. A slight decrement in accuracy emerged for pseudoword repetition, short-term memory and working memory, phonological processing, and verbal comprehension. Total resection was performed, and the histological examination confirmed the nature of the lesion. Immediate postsurgery performance was within the normal range as it was the fMRI and DTI assessment.Conclusion: The RTNT provides essential information that can be used online, during surgery, for clinical aims to provide the surgeon with useful feedback on the cognitive status of patients.
format	article
author	Barbara Tomasino Ilaria Guarracino Tamara Ius Marta Maieron Miran Skrap
author_facet	Barbara Tomasino Ilaria Guarracino Tamara Ius Marta Maieron Miran Skrap
author_sort	Barbara Tomasino
title	Real-Time Neuropsychological Testing Protocol for Left Temporal Brain Tumor Surgery: A Technical Note and Case Report
title_short	Real-Time Neuropsychological Testing Protocol for Left Temporal Brain Tumor Surgery: A Technical Note and Case Report
title_full	Real-Time Neuropsychological Testing Protocol for Left Temporal Brain Tumor Surgery: A Technical Note and Case Report
title_fullStr	Real-Time Neuropsychological Testing Protocol for Left Temporal Brain Tumor Surgery: A Technical Note and Case Report
title_full_unstemmed	Real-Time Neuropsychological Testing Protocol for Left Temporal Brain Tumor Surgery: A Technical Note and Case Report
title_sort	real-time neuropsychological testing protocol for left temporal brain tumor surgery: a technical note and case report
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d4471ca2f95e47dfa96de7da37b7bf7b
work_keys_str_mv	AT barbaratomasino realtimeneuropsychologicaltestingprotocolforlefttemporalbraintumorsurgeryatechnicalnoteandcasereport AT ilariaguarracino realtimeneuropsychologicaltestingprotocolforlefttemporalbraintumorsurgeryatechnicalnoteandcasereport AT tamaraius realtimeneuropsychologicaltestingprotocolforlefttemporalbraintumorsurgeryatechnicalnoteandcasereport AT martamaieron realtimeneuropsychologicaltestingprotocolforlefttemporalbraintumorsurgeryatechnicalnoteandcasereport AT miranskrap realtimeneuropsychologicaltestingprotocolforlefttemporalbraintumorsurgeryatechnicalnoteandcasereport
_version_	1718373957106663424

Real-Time Neuropsychological Testing Protocol for Left Temporal Brain Tumor Surgery: A Technical Note and Case Report

Ejemplares similares