Neurotrophin receptor tyrosine kinases regulated with near-infrared light
Optical control over receptor tyrosine kinase (RTK) activity can find application in both basic biology and synthetic biology. Here the authors combine the photosensory module of DrBphP bacterial phytochrome with the Trk family of RTKs to obtain Trks that are reversibly switchable with near-infrared...
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Nature Portfolio
2019
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oai:doaj.org-article:d447bf17660142128b2c06f41c7921192021-12-02T14:39:39ZNeurotrophin receptor tyrosine kinases regulated with near-infrared light10.1038/s41467-019-08988-32041-1723https://doaj.org/article/d447bf17660142128b2c06f41c7921192019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08988-3https://doaj.org/toc/2041-1723Optical control over receptor tyrosine kinase (RTK) activity can find application in both basic biology and synthetic biology. Here the authors combine the photosensory module of DrBphP bacterial phytochrome with the Trk family of RTKs to obtain Trks that are reversibly switchable with near-infrared and far-red light.Anna V. LeopoldKonstantin G. ChernovAnton A. ShemetovVladislav V. VerkhushaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
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Science Q Anna V. Leopold Konstantin G. Chernov Anton A. Shemetov Vladislav V. Verkhusha Neurotrophin receptor tyrosine kinases regulated with near-infrared light |
description |
Optical control over receptor tyrosine kinase (RTK) activity can find application in both basic biology and synthetic biology. Here the authors combine the photosensory module of DrBphP bacterial phytochrome with the Trk family of RTKs to obtain Trks that are reversibly switchable with near-infrared and far-red light. |
format |
article |
author |
Anna V. Leopold Konstantin G. Chernov Anton A. Shemetov Vladislav V. Verkhusha |
author_facet |
Anna V. Leopold Konstantin G. Chernov Anton A. Shemetov Vladislav V. Verkhusha |
author_sort |
Anna V. Leopold |
title |
Neurotrophin receptor tyrosine kinases regulated with near-infrared light |
title_short |
Neurotrophin receptor tyrosine kinases regulated with near-infrared light |
title_full |
Neurotrophin receptor tyrosine kinases regulated with near-infrared light |
title_fullStr |
Neurotrophin receptor tyrosine kinases regulated with near-infrared light |
title_full_unstemmed |
Neurotrophin receptor tyrosine kinases regulated with near-infrared light |
title_sort |
neurotrophin receptor tyrosine kinases regulated with near-infrared light |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/d447bf17660142128b2c06f41c792119 |
work_keys_str_mv |
AT annavleopold neurotrophinreceptortyrosinekinasesregulatedwithnearinfraredlight AT konstantingchernov neurotrophinreceptortyrosinekinasesregulatedwithnearinfraredlight AT antonashemetov neurotrophinreceptortyrosinekinasesregulatedwithnearinfraredlight AT vladislavvverkhusha neurotrophinreceptortyrosinekinasesregulatedwithnearinfraredlight |
_version_ |
1718390561565573120 |