Clinicopathological characteristics and prognostic factors of cervical adenocarcinoma

Abstract We aimed to assess the clinicopathological features and to determine the prognostic factors of cervical adenocarcinoma (AC). Relevant data were extracted from surveillance, epidemiology and end results database from 2004 to 2015. The log-rank test and Cox proportional hazard analysis were s...

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Autores principales:	Min Wang, Bo Yuan, Zhen-huan Zhou, Wei-wei Han
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d44ca05984d84a71a78f6d403b94d652
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spelling	oai:doaj.org-article:d44ca05984d84a71a78f6d403b94d6522021-12-02T14:21:16ZClinicopathological characteristics and prognostic factors of cervical adenocarcinoma10.1038/s41598-021-86786-y2045-2322https://doaj.org/article/d44ca05984d84a71a78f6d403b94d6522021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86786-yhttps://doaj.org/toc/2045-2322Abstract We aimed to assess the clinicopathological features and to determine the prognostic factors of cervical adenocarcinoma (AC). Relevant data were extracted from surveillance, epidemiology and end results database from 2004 to 2015. The log-rank test and Cox proportional hazard analysis were subsequently utilized to identify independent prognostic factors. A total of 3102 patients were identified. The enrolled patients were characterized by higher proportion of early FIGO stage (stage I: 65.9%; stage II: 14.1%), low pathological grade (grade I/II: 49.1%) and tumor size ≤ 4 cm (46.8%). The 5- and 10-year cancer-specific survival rates of these patients were 74.47% and 70.00%, respectively. Meanwhile, the 5- and 10-year overall survival (OS) rates were 71.52% and 65.17%, respectively. Multivariate analysis revealed that married status, surgery as well as chemotherapy were independent favorable prognostic indicators. Additionally, aged > 45, tumor grade III/IV, tumor size > 4 cm, advanced FIGO stage and pelvic lymph node metastasis (LNM) were unfavorable prognostic factors (all P < 0.01). Stratified analysis found that patients without surgery could significantly benefit from chemotherapy and radiotherapy. In addition, chemotherapy could significantly improve the survival in stage II–IV patients and radiotherapy could only improve the survival in stage III patients (all P < 0.01). Marital status, age, grade, tumor size, FIGO stage, surgery, pelvic LNM and chemotherapy were significantly associated with the prognosis of cervical AC.Min WangBo YuanZhen-huan ZhouWei-wei HanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Min Wang Bo Yuan Zhen-huan Zhou Wei-wei Han Clinicopathological characteristics and prognostic factors of cervical adenocarcinoma
description	Abstract We aimed to assess the clinicopathological features and to determine the prognostic factors of cervical adenocarcinoma (AC). Relevant data were extracted from surveillance, epidemiology and end results database from 2004 to 2015. The log-rank test and Cox proportional hazard analysis were subsequently utilized to identify independent prognostic factors. A total of 3102 patients were identified. The enrolled patients were characterized by higher proportion of early FIGO stage (stage I: 65.9%; stage II: 14.1%), low pathological grade (grade I/II: 49.1%) and tumor size ≤ 4 cm (46.8%). The 5- and 10-year cancer-specific survival rates of these patients were 74.47% and 70.00%, respectively. Meanwhile, the 5- and 10-year overall survival (OS) rates were 71.52% and 65.17%, respectively. Multivariate analysis revealed that married status, surgery as well as chemotherapy were independent favorable prognostic indicators. Additionally, aged > 45, tumor grade III/IV, tumor size > 4 cm, advanced FIGO stage and pelvic lymph node metastasis (LNM) were unfavorable prognostic factors (all P < 0.01). Stratified analysis found that patients without surgery could significantly benefit from chemotherapy and radiotherapy. In addition, chemotherapy could significantly improve the survival in stage II–IV patients and radiotherapy could only improve the survival in stage III patients (all P < 0.01). Marital status, age, grade, tumor size, FIGO stage, surgery, pelvic LNM and chemotherapy were significantly associated with the prognosis of cervical AC.
format	article
author	Min Wang Bo Yuan Zhen-huan Zhou Wei-wei Han
author_facet	Min Wang Bo Yuan Zhen-huan Zhou Wei-wei Han
author_sort	Min Wang
title	Clinicopathological characteristics and prognostic factors of cervical adenocarcinoma
title_short	Clinicopathological characteristics and prognostic factors of cervical adenocarcinoma
title_full	Clinicopathological characteristics and prognostic factors of cervical adenocarcinoma
title_fullStr	Clinicopathological characteristics and prognostic factors of cervical adenocarcinoma
title_full_unstemmed	Clinicopathological characteristics and prognostic factors of cervical adenocarcinoma
title_sort	clinicopathological characteristics and prognostic factors of cervical adenocarcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d44ca05984d84a71a78f6d403b94d652
work_keys_str_mv	AT minwang clinicopathologicalcharacteristicsandprognosticfactorsofcervicaladenocarcinoma AT boyuan clinicopathologicalcharacteristicsandprognosticfactorsofcervicaladenocarcinoma AT zhenhuanzhou clinicopathologicalcharacteristicsandprognosticfactorsofcervicaladenocarcinoma AT weiweihan clinicopathologicalcharacteristicsandprognosticfactorsofcervicaladenocarcinoma
_version_	1718391576285151232

Clinicopathological characteristics and prognostic factors of cervical adenocarcinoma

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