Evaluation of Corneal Biomechanical Parameters in Psoriasis Patients: A Controlled Study

Noha A Edris,1 Shaimaa A Arfeen,1 Rana Mosaad,2 Ghada A Nassar1 1Ophthalmology Department, Cairo University, Faculty of Medicine, Cairo, Egypt; 2Dermatology Department, Cairo University, Faculty of Medicine, Cairo, EgyptCorrespondence: Ghada A Nassar 10 Said Street, Heliopolis, Cairo 11757, EgyptTel...

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Autores principales:	Edris NA, Arfeen SA, Mosaad R, Nassar GA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	psoriasis – corneal hysteresis – corneal resistance factor – corneal compensated intraocular pressure – ocular response analyzer Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/d44cb2dfd148499db92fc153be526d89
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spelling	oai:doaj.org-article:d44cb2dfd148499db92fc153be526d892021-12-02T13:02:48ZEvaluation of Corneal Biomechanical Parameters in Psoriasis Patients: A Controlled Study1177-5483https://doaj.org/article/d44cb2dfd148499db92fc153be526d892020-06-01T00:00:00Zhttps://www.dovepress.com/evaluation-of-corneal-biomechanical-parameters-in-psoriasis-patients-a-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Noha A Edris,1 Shaimaa A Arfeen,1 Rana Mosaad,2 Ghada A Nassar1 1Ophthalmology Department, Cairo University, Faculty of Medicine, Cairo, Egypt; 2Dermatology Department, Cairo University, Faculty of Medicine, Cairo, EgyptCorrespondence: Ghada A Nassar 10 Said Street, Heliopolis, Cairo 11757, EgyptTel +201222397300Fax +20226677060Email ghada.azab2010@gmail.comPurpose: To evaluate corneal biomechanical parameters with an ocular response analyzer (ORA) in patients with psoriasis and compare these parameters with age-matched control subjects.Study Design: This was a cross-sectional observational case–control study.Methods: Thirty eyes of 15 psoriasis patients were included in the study and compared with 30 eyes of 15 control subjects. Corneal biomechanical properties were calculated by ORA. Central corneal thickness (CCT) was measured by anterior-segment optical coherence tomography. The main outcome measures were corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOPcc), and Goldmann-correlated IOP (IOPg). For dry-eye evaluation, Schirmer’s test was used.Results: Mean CH in the psoriasis group was 10.20± 1.55 mmHg and in the control group 10.66± 1.36 mmHg (p=0.215). Mean CRF in the psoriasis group was 9.76± 1.60 mmHg and in the control group 10.97± 1.42 mmHg (p=0.003). Mean IOPcc in the psoriasis group was 14.84± 3.43 mmHg and in the control group 16.67± 3.17 mmHg (p=0.035). Mean IOPg in the psoriasis group was 13.92± 3.35 mmHg and in the control group 16.62± 3.10 mmHg (p=0.002). Mean CCT in the psoriasis group was 543.90± 37.27 μm and in the control group 551.23± 28.63 μm (p=0.392). Schirmer’s test results in the psoriasis group were 11.4± 1.57 mm/5 min and in the control group 17.5± 1.52 mm/5 min (p< 0.001).Conclusion: Psoriasis affects corneal biomechanical properties with statistically significantly lower corneal biomechanics than normal. CH correlates negatively with disease activity. These corneal biomechanical changes should be considered when determining IOP values and during corneal evaluation for keratoconus-suspected patients.Keywords: psoriasis, corneal hysteresis, corneal resistance factor, corneal-compensated intraocular pressure, ocular response analyzerEdris NAArfeen SAMosaad RNassar GADove Medical Pressarticlepsoriasis – corneal hysteresis – corneal resistance factor – corneal compensated intraocular pressure – ocular response analyzerOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 1833-1837 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis – corneal hysteresis – corneal resistance factor – corneal compensated intraocular pressure – ocular response analyzer Ophthalmology RE1-994
spellingShingle	psoriasis – corneal hysteresis – corneal resistance factor – corneal compensated intraocular pressure – ocular response analyzer Ophthalmology RE1-994 Edris NA Arfeen SA Mosaad R Nassar GA Evaluation of Corneal Biomechanical Parameters in Psoriasis Patients: A Controlled Study
description	Noha A Edris,1 Shaimaa A Arfeen,1 Rana Mosaad,2 Ghada A Nassar1 1Ophthalmology Department, Cairo University, Faculty of Medicine, Cairo, Egypt; 2Dermatology Department, Cairo University, Faculty of Medicine, Cairo, EgyptCorrespondence: Ghada A Nassar 10 Said Street, Heliopolis, Cairo 11757, EgyptTel +201222397300Fax +20226677060Email ghada.azab2010@gmail.comPurpose: To evaluate corneal biomechanical parameters with an ocular response analyzer (ORA) in patients with psoriasis and compare these parameters with age-matched control subjects.Study Design: This was a cross-sectional observational case–control study.Methods: Thirty eyes of 15 psoriasis patients were included in the study and compared with 30 eyes of 15 control subjects. Corneal biomechanical properties were calculated by ORA. Central corneal thickness (CCT) was measured by anterior-segment optical coherence tomography. The main outcome measures were corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOPcc), and Goldmann-correlated IOP (IOPg). For dry-eye evaluation, Schirmer’s test was used.Results: Mean CH in the psoriasis group was 10.20± 1.55 mmHg and in the control group 10.66± 1.36 mmHg (p=0.215). Mean CRF in the psoriasis group was 9.76± 1.60 mmHg and in the control group 10.97± 1.42 mmHg (p=0.003). Mean IOPcc in the psoriasis group was 14.84± 3.43 mmHg and in the control group 16.67± 3.17 mmHg (p=0.035). Mean IOPg in the psoriasis group was 13.92± 3.35 mmHg and in the control group 16.62± 3.10 mmHg (p=0.002). Mean CCT in the psoriasis group was 543.90± 37.27 μm and in the control group 551.23± 28.63 μm (p=0.392). Schirmer’s test results in the psoriasis group were 11.4± 1.57 mm/5 min and in the control group 17.5± 1.52 mm/5 min (p< 0.001).Conclusion: Psoriasis affects corneal biomechanical properties with statistically significantly lower corneal biomechanics than normal. CH correlates negatively with disease activity. These corneal biomechanical changes should be considered when determining IOP values and during corneal evaluation for keratoconus-suspected patients.Keywords: psoriasis, corneal hysteresis, corneal resistance factor, corneal-compensated intraocular pressure, ocular response analyzer
format	article
author	Edris NA Arfeen SA Mosaad R Nassar GA
author_facet	Edris NA Arfeen SA Mosaad R Nassar GA
author_sort	Edris NA
title	Evaluation of Corneal Biomechanical Parameters in Psoriasis Patients: A Controlled Study
title_short	Evaluation of Corneal Biomechanical Parameters in Psoriasis Patients: A Controlled Study
title_full	Evaluation of Corneal Biomechanical Parameters in Psoriasis Patients: A Controlled Study
title_fullStr	Evaluation of Corneal Biomechanical Parameters in Psoriasis Patients: A Controlled Study
title_full_unstemmed	Evaluation of Corneal Biomechanical Parameters in Psoriasis Patients: A Controlled Study
title_sort	evaluation of corneal biomechanical parameters in psoriasis patients: a controlled study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/d44cb2dfd148499db92fc153be526d89
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_version_	1718393531835351040

Evaluation of Corneal Biomechanical Parameters in Psoriasis Patients: A Controlled Study

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