Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex
Targeting noncoding nucleic acids with small molecules represents an important and significant challenge in chemical biology and drug discovery. Here the authors characterize DC-34, a small molecule that exhibits selective binding to specific G4 structures, and provide a structural basis for its sel...
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Nature Portfolio
2018
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oai:doaj.org-article:d45674f52573447395e321fc6dc2bc802021-12-02T17:32:47ZChemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex10.1038/s41467-018-06315-w2041-1723https://doaj.org/article/d45674f52573447395e321fc6dc2bc802018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06315-whttps://doaj.org/toc/2041-1723Targeting noncoding nucleic acids with small molecules represents an important and significant challenge in chemical biology and drug discovery. Here the authors characterize DC-34, a small molecule that exhibits selective binding to specific G4 structures, and provide a structural basis for its selectivityDavid R. CalabreseXiang ChenElena C. LeonSnehal M. GaikwadZaw PhyoWilliam M. HewittStephanie AldenThomas A. HilimireFahu HeAleksandra M. MichalowskiJohn K. SimmonsLindsey B. SaundersShuling ZhangDaniel ConnorsKylie J. WaltersBeverly A. MockJohn S. SchneeklothNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q David R. Calabrese Xiang Chen Elena C. Leon Snehal M. Gaikwad Zaw Phyo William M. Hewitt Stephanie Alden Thomas A. Hilimire Fahu He Aleksandra M. Michalowski John K. Simmons Lindsey B. Saunders Shuling Zhang Daniel Connors Kylie J. Walters Beverly A. Mock John S. Schneekloth Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex |
| description |
Targeting noncoding nucleic acids with small molecules represents an important and significant challenge in chemical biology and drug discovery. Here the authors characterize DC-34, a small molecule that exhibits selective binding to specific G4 structures, and provide a structural basis for its selectivity |
| format |
article |
| author |
David R. Calabrese Xiang Chen Elena C. Leon Snehal M. Gaikwad Zaw Phyo William M. Hewitt Stephanie Alden Thomas A. Hilimire Fahu He Aleksandra M. Michalowski John K. Simmons Lindsey B. Saunders Shuling Zhang Daniel Connors Kylie J. Walters Beverly A. Mock John S. Schneekloth |
| author_facet |
David R. Calabrese Xiang Chen Elena C. Leon Snehal M. Gaikwad Zaw Phyo William M. Hewitt Stephanie Alden Thomas A. Hilimire Fahu He Aleksandra M. Michalowski John K. Simmons Lindsey B. Saunders Shuling Zhang Daniel Connors Kylie J. Walters Beverly A. Mock John S. Schneekloth |
| author_sort |
David R. Calabrese |
| title |
Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex |
| title_short |
Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex |
| title_full |
Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex |
| title_fullStr |
Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex |
| title_full_unstemmed |
Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex |
| title_sort |
chemical and structural studies provide a mechanistic basis for recognition of the myc g-quadruplex |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/d45674f52573447395e321fc6dc2bc80 |
| work_keys_str_mv |
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