p-Hydroxybenzoic acid alleviates inflammatory responses and intestinal mucosal damage in DSS-induced colitis by activating ERβ signaling

p-Hydroxybenzaldehyde (HD), the main active component of Nostoc commune, has been shown to attenuate dextran sulfate sodium (DSS)-induced experimental colitis. However, it is still unclear whether HD or its metabolites exert a protective role in ulcerative colitis (UC). In this study, we showed that...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiaotian Xu, Ailin Luo, Xi Lu, Meng Liu, Huideng Wang, Hengzhi Song, Chengqiong Wei, Yuhui Wang, Xiaoqun Duan
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Ulcerative colitis P-hydroxybenzoic acid Inflammatory response Intestinal mucosal damage Estrogen receptor β Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/d456aa801e654ef4a5fced13ef650a27
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d456aa801e654ef4a5fced13ef650a27
record_format	dspace
spelling	oai:doaj.org-article:d456aa801e654ef4a5fced13ef650a272021-11-10T04:21:49Zp-Hydroxybenzoic acid alleviates inflammatory responses and intestinal mucosal damage in DSS-induced colitis by activating ERβ signaling1756-464610.1016/j.jff.2021.104835https://doaj.org/article/d456aa801e654ef4a5fced13ef650a272021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1756464621004849https://doaj.org/toc/1756-4646p-Hydroxybenzaldehyde (HD), the main active component of Nostoc commune, has been shown to attenuate dextran sulfate sodium (DSS)-induced experimental colitis. However, it is still unclear whether HD or its metabolites exert a protective role in ulcerative colitis (UC). In this study, we showed that p-hydroxybenzoic acid (HA) is the active metabolite of HD and demonstrated the effects of HA in alleviating colitis and its potential mechanism. Mice with colitis induced by DSS were orally administered or intraperitoneally injected with therapeutic drugs (including HD, HA, mesalazine and PHTPP) for 10 days. Caco-2 cells were treated with TNF-α (10 ng/ml) and therapeutic drugs (including HA, mesalazine and PHTPP) for 24 h. The results showed that oral supplementation, but not intraperitoneal injection, of HD (40 mg/kg) significantly ameliorated DSS-induced colitis. Oral administration of HA (10-40 mg/kg) dose-dependently attenuated various colitis phenotypes in DSS-treated mice. Treatment with HA also decreased the expression of proinflammatory cytokines and increased the expression of tight junction proteins in mice and Caco-2 cells. However, combined treatment of HA with PHTPP, a highly selective antagonist of the estrogen receptor β (ERβ), did not show anti-colitis effects. Collectively, our results demonstrate that both HD and HA are active substances capable of inhibiting inflammatory responses and improving intestinal mucosal damage via the activation of ERβ signaling in DSS-induced colitis.Xiaotian XuAilin LuoXi LuMeng LiuHuideng WangHengzhi SongChengqiong WeiYuhui WangXiaoqun DuanElsevierarticleUlcerative colitisP-hydroxybenzoic acidInflammatory responseIntestinal mucosal damageEstrogen receptor βNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 87, Iss , Pp 104835- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ulcerative colitis P-hydroxybenzoic acid Inflammatory response Intestinal mucosal damage Estrogen receptor β Nutrition. Foods and food supply TX341-641
spellingShingle	Ulcerative colitis P-hydroxybenzoic acid Inflammatory response Intestinal mucosal damage Estrogen receptor β Nutrition. Foods and food supply TX341-641 Xiaotian Xu Ailin Luo Xi Lu Meng Liu Huideng Wang Hengzhi Song Chengqiong Wei Yuhui Wang Xiaoqun Duan p-Hydroxybenzoic acid alleviates inflammatory responses and intestinal mucosal damage in DSS-induced colitis by activating ERβ signaling
description	p-Hydroxybenzaldehyde (HD), the main active component of Nostoc commune, has been shown to attenuate dextran sulfate sodium (DSS)-induced experimental colitis. However, it is still unclear whether HD or its metabolites exert a protective role in ulcerative colitis (UC). In this study, we showed that p-hydroxybenzoic acid (HA) is the active metabolite of HD and demonstrated the effects of HA in alleviating colitis and its potential mechanism. Mice with colitis induced by DSS were orally administered or intraperitoneally injected with therapeutic drugs (including HD, HA, mesalazine and PHTPP) for 10 days. Caco-2 cells were treated with TNF-α (10 ng/ml) and therapeutic drugs (including HA, mesalazine and PHTPP) for 24 h. The results showed that oral supplementation, but not intraperitoneal injection, of HD (40 mg/kg) significantly ameliorated DSS-induced colitis. Oral administration of HA (10-40 mg/kg) dose-dependently attenuated various colitis phenotypes in DSS-treated mice. Treatment with HA also decreased the expression of proinflammatory cytokines and increased the expression of tight junction proteins in mice and Caco-2 cells. However, combined treatment of HA with PHTPP, a highly selective antagonist of the estrogen receptor β (ERβ), did not show anti-colitis effects. Collectively, our results demonstrate that both HD and HA are active substances capable of inhibiting inflammatory responses and improving intestinal mucosal damage via the activation of ERβ signaling in DSS-induced colitis.
format	article
author	Xiaotian Xu Ailin Luo Xi Lu Meng Liu Huideng Wang Hengzhi Song Chengqiong Wei Yuhui Wang Xiaoqun Duan
author_facet	Xiaotian Xu Ailin Luo Xi Lu Meng Liu Huideng Wang Hengzhi Song Chengqiong Wei Yuhui Wang Xiaoqun Duan
author_sort	Xiaotian Xu
title	p-Hydroxybenzoic acid alleviates inflammatory responses and intestinal mucosal damage in DSS-induced colitis by activating ERβ signaling
title_short	p-Hydroxybenzoic acid alleviates inflammatory responses and intestinal mucosal damage in DSS-induced colitis by activating ERβ signaling
title_full	p-Hydroxybenzoic acid alleviates inflammatory responses and intestinal mucosal damage in DSS-induced colitis by activating ERβ signaling
title_fullStr	p-Hydroxybenzoic acid alleviates inflammatory responses and intestinal mucosal damage in DSS-induced colitis by activating ERβ signaling
title_full_unstemmed	p-Hydroxybenzoic acid alleviates inflammatory responses and intestinal mucosal damage in DSS-induced colitis by activating ERβ signaling
title_sort	p-hydroxybenzoic acid alleviates inflammatory responses and intestinal mucosal damage in dss-induced colitis by activating erβ signaling
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d456aa801e654ef4a5fced13ef650a27
work_keys_str_mv	AT xiaotianxu phydroxybenzoicacidalleviatesinflammatoryresponsesandintestinalmucosaldamageindssinducedcolitisbyactivatingerbsignaling AT ailinluo phydroxybenzoicacidalleviatesinflammatoryresponsesandintestinalmucosaldamageindssinducedcolitisbyactivatingerbsignaling AT xilu phydroxybenzoicacidalleviatesinflammatoryresponsesandintestinalmucosaldamageindssinducedcolitisbyactivatingerbsignaling AT mengliu phydroxybenzoicacidalleviatesinflammatoryresponsesandintestinalmucosaldamageindssinducedcolitisbyactivatingerbsignaling AT huidengwang phydroxybenzoicacidalleviatesinflammatoryresponsesandintestinalmucosaldamageindssinducedcolitisbyactivatingerbsignaling AT hengzhisong phydroxybenzoicacidalleviatesinflammatoryresponsesandintestinalmucosaldamageindssinducedcolitisbyactivatingerbsignaling AT chengqiongwei phydroxybenzoicacidalleviatesinflammatoryresponsesandintestinalmucosaldamageindssinducedcolitisbyactivatingerbsignaling AT yuhuiwang phydroxybenzoicacidalleviatesinflammatoryresponsesandintestinalmucosaldamageindssinducedcolitisbyactivatingerbsignaling AT xiaoqunduan phydroxybenzoicacidalleviatesinflammatoryresponsesandintestinalmucosaldamageindssinducedcolitisbyactivatingerbsignaling
_version_	1718440695846404096

p-Hydroxybenzoic acid alleviates inflammatory responses and intestinal mucosal damage in DSS-induced colitis by activating ERβ signaling

Ejemplares similares