Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling

Kakoki et al report a role for cyanocobalamin (B12) in preventing cardiomyopathy in type 1 diabetic mice, by reducing levels of reactive oxygen species and restoring IGF-1 levels via DNMT-SOCS1/3 signalling. The authors therefore propose B12 as a promising option to prevent diabetic cardiomyopathy t...

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Autores principales:	Masao Kakoki, Purushotham V. Ramanathan, John R. Hagaman, Ruriko Grant, Jennifer C. Wilder, Joan M. Taylor, J. Charles Jennette, Oliver Smithies, Nobuyo Maeda-Smithies
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d458d85b19244ce497e74c59bd94bf79
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spelling	oai:doaj.org-article:d458d85b19244ce497e74c59bd94bf792021-12-02T17:14:23ZCyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling10.1038/s42003-021-02291-y2399-3642https://doaj.org/article/d458d85b19244ce497e74c59bd94bf792021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02291-yhttps://doaj.org/toc/2399-3642Kakoki et al report a role for cyanocobalamin (B12) in preventing cardiomyopathy in type 1 diabetic mice, by reducing levels of reactive oxygen species and restoring IGF-1 levels via DNMT-SOCS1/3 signalling. The authors therefore propose B12 as a promising option to prevent diabetic cardiomyopathy through its cardioprotective effects.Masao KakokiPurushotham V. RamanathanJohn R. HagamanRuriko GrantJennifer C. WilderJoan M. TaylorJ. Charles JennetteOliver SmithiesNobuyo Maeda-SmithiesNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Masao Kakoki Purushotham V. Ramanathan John R. Hagaman Ruriko Grant Jennifer C. Wilder Joan M. Taylor J. Charles Jennette Oliver Smithies Nobuyo Maeda-Smithies Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling
description	Kakoki et al report a role for cyanocobalamin (B12) in preventing cardiomyopathy in type 1 diabetic mice, by reducing levels of reactive oxygen species and restoring IGF-1 levels via DNMT-SOCS1/3 signalling. The authors therefore propose B12 as a promising option to prevent diabetic cardiomyopathy through its cardioprotective effects.
format	article
author	Masao Kakoki Purushotham V. Ramanathan John R. Hagaman Ruriko Grant Jennifer C. Wilder Joan M. Taylor J. Charles Jennette Oliver Smithies Nobuyo Maeda-Smithies
author_facet	Masao Kakoki Purushotham V. Ramanathan John R. Hagaman Ruriko Grant Jennifer C. Wilder Joan M. Taylor J. Charles Jennette Oliver Smithies Nobuyo Maeda-Smithies
author_sort	Masao Kakoki
title	Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling
title_short	Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling
title_full	Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling
title_fullStr	Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling
title_full_unstemmed	Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling
title_sort	cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and dnmt-socs1/3-igf-1 signaling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d458d85b19244ce497e74c59bd94bf79
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Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling

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