Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling

Kakoki et al report a role for cyanocobalamin (B12) in preventing cardiomyopathy in type 1 diabetic mice, by reducing levels of reactive oxygen species and restoring IGF-1 levels via DNMT-SOCS1/3 signalling. The authors therefore propose B12 as a promising option to prevent diabetic cardiomyopathy t...

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Autores principales: Masao Kakoki, Purushotham V. Ramanathan, John R. Hagaman, Ruriko Grant, Jennifer C. Wilder, Joan M. Taylor, J. Charles Jennette, Oliver Smithies, Nobuyo Maeda-Smithies
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/d458d85b19244ce497e74c59bd94bf79
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