Pregnancy-related systemic lupus erythematosus: clinical features, outcome and risk factors of disease flares--a case control study.

<h4>Objective</h4>To investigate the clinical features, outcome, and risk factors of disease flares in patients with pregnancy-related lupus (PRL).<h4>Methods</h4>Medical charts of 155 consecutive PRL inpatients were systematically reviewed, including demographic data, clinic...

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Autores principales:	Huaxia Yang, Hui Liu, Dong Xu, Lidan Zhao, Qian Wang, Xiaomei Leng, Wenjie Zheng, Fengchun Zhang, Fulin Tang, Xuan Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d45a59def63b4b34bedab24ab0116735
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spelling	oai:doaj.org-article:d45a59def63b4b34bedab24ab01167352021-11-25T06:05:00ZPregnancy-related systemic lupus erythematosus: clinical features, outcome and risk factors of disease flares--a case control study.1932-620310.1371/journal.pone.0104375https://doaj.org/article/d45a59def63b4b34bedab24ab01167352014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25118692/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To investigate the clinical features, outcome, and risk factors of disease flares in patients with pregnancy-related lupus (PRL).<h4>Methods</h4>Medical charts of 155 consecutive PRL inpatients were systematically reviewed, including demographic data, clinical features, laboratory findings, treatment, complications, and outcome.<h4>Results</h4>PRL cases were divided into active (a-PRL) (n = 82, 53.0%) and stable lupus (s-PRL) (n = 73, 47.0%). Compared with nonpregnant active female systemic lupus erythematosus (SLE) patients, a-PRL including new-onset lupus (n-PRL) and flare lupus (f-PRL) (n = 41 respectively), had a higher incidence of renal and hematological involvement but less mucocutaneous and musculoskeletal involvement (p<0.05). The incidence of preeclampsia/eclampsia, fetal loss, and preterm birth were significantly higher in a-PRL than in s-PRL (p<0.05). Despite receiving a more vigorous glucocorticoid treatment, a-PRL mothers had a poorer prognosis (p<0.001). Five (6.1%) of them died and 13 (15.9%) developed severe irreversible organ failure, whereas none of these events was observed in the s-PRL group. Multivariate logistic analysis indicated that a history of lupus flares and serological activity (hypocomplementemia and/or anti-dsDNA positivity) at the time of conception were associated with lupus flares in PRL mothers.<h4>Conclusions</h4>SLE patients with a flare history and serological activity at the time of conception were at an increased risk of disease flares during pregnancy and puerperium. a-PRL patients were more prone to renal and hematological involvement, pregnancy complications, and a poorer prognosis despite more vigorous glucocorticoid treatment.Huaxia YangHui LiuDong XuLidan ZhaoQian WangXiaomei LengWenjie ZhengFengchun ZhangFulin TangXuan ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e104375 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huaxia Yang Hui Liu Dong Xu Lidan Zhao Qian Wang Xiaomei Leng Wenjie Zheng Fengchun Zhang Fulin Tang Xuan Zhang Pregnancy-related systemic lupus erythematosus: clinical features, outcome and risk factors of disease flares--a case control study.
description	<h4>Objective</h4>To investigate the clinical features, outcome, and risk factors of disease flares in patients with pregnancy-related lupus (PRL).<h4>Methods</h4>Medical charts of 155 consecutive PRL inpatients were systematically reviewed, including demographic data, clinical features, laboratory findings, treatment, complications, and outcome.<h4>Results</h4>PRL cases were divided into active (a-PRL) (n = 82, 53.0%) and stable lupus (s-PRL) (n = 73, 47.0%). Compared with nonpregnant active female systemic lupus erythematosus (SLE) patients, a-PRL including new-onset lupus (n-PRL) and flare lupus (f-PRL) (n = 41 respectively), had a higher incidence of renal and hematological involvement but less mucocutaneous and musculoskeletal involvement (p<0.05). The incidence of preeclampsia/eclampsia, fetal loss, and preterm birth were significantly higher in a-PRL than in s-PRL (p<0.05). Despite receiving a more vigorous glucocorticoid treatment, a-PRL mothers had a poorer prognosis (p<0.001). Five (6.1%) of them died and 13 (15.9%) developed severe irreversible organ failure, whereas none of these events was observed in the s-PRL group. Multivariate logistic analysis indicated that a history of lupus flares and serological activity (hypocomplementemia and/or anti-dsDNA positivity) at the time of conception were associated with lupus flares in PRL mothers.<h4>Conclusions</h4>SLE patients with a flare history and serological activity at the time of conception were at an increased risk of disease flares during pregnancy and puerperium. a-PRL patients were more prone to renal and hematological involvement, pregnancy complications, and a poorer prognosis despite more vigorous glucocorticoid treatment.
format	article
author	Huaxia Yang Hui Liu Dong Xu Lidan Zhao Qian Wang Xiaomei Leng Wenjie Zheng Fengchun Zhang Fulin Tang Xuan Zhang
author_facet	Huaxia Yang Hui Liu Dong Xu Lidan Zhao Qian Wang Xiaomei Leng Wenjie Zheng Fengchun Zhang Fulin Tang Xuan Zhang
author_sort	Huaxia Yang
title	Pregnancy-related systemic lupus erythematosus: clinical features, outcome and risk factors of disease flares--a case control study.
title_short	Pregnancy-related systemic lupus erythematosus: clinical features, outcome and risk factors of disease flares--a case control study.
title_full	Pregnancy-related systemic lupus erythematosus: clinical features, outcome and risk factors of disease flares--a case control study.
title_fullStr	Pregnancy-related systemic lupus erythematosus: clinical features, outcome and risk factors of disease flares--a case control study.
title_full_unstemmed	Pregnancy-related systemic lupus erythematosus: clinical features, outcome and risk factors of disease flares--a case control study.
title_sort	pregnancy-related systemic lupus erythematosus: clinical features, outcome and risk factors of disease flares--a case control study.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/d45a59def63b4b34bedab24ab0116735
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Pregnancy-related systemic lupus erythematosus: clinical features, outcome and risk factors of disease flares--a case control study.

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