Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells.

Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells.

Plasmacytoid dendritic cells (pDCs) play a key role in detecting pathogens by producing large amounts of type I interferon (IFN) by sensing the presence of viral infections through the Toll-Like Receptor (TLR) pathway. TLR9 is a sensor of viral and bacterial DNA motifs and activates the IRF7 transcr...

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Autores principales: Isabelle E Vincent, Claudia Zannetti, Julie Lucifora, Helene Norder, Ulrike Protzer, Pierre Hainaut, Fabien Zoulim, Massimo Tommasino, Christian Trépo, Uzma Hasan, Isabelle Chemin
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/d45d4ebe64094904980916be6ddcd6cc
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