Evaluation of electrical impedance spectroscopy as an adjunct to dermoscopy in short-term monitoring of atypical melanocytic lesions

Background: Early detection of melanoma is vital for treatment outcome and survival. Short-term sequential digital dermoscopic monitoring (ST-SDDM) involves the capture and assessment of dermoscopic images of one or more atypical melanocytic lesions (AMLs), at baseline and after four months, in ord...

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Autores principales:	Hannah Ceder, Alexandra Sjöholm Hylén, Ann-Marie Wennberg Larkö, John Paoli
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2016
Materias:	dermoscopy atypical melanocytic lesion melanoma short-term monitoring electrical impedance spectroscopy Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/d461154a333541bdaa8f890f0b3f988e
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spelling	oai:doaj.org-article:d461154a333541bdaa8f890f0b3f988e2021-11-17T08:31:00ZEvaluation of electrical impedance spectroscopy as an adjunct to dermoscopy in short-term monitoring of atypical melanocytic lesions10.5826/dpc.0604a012160-9381https://doaj.org/article/d461154a333541bdaa8f890f0b3f988e2016-10-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/170https://doaj.org/toc/2160-9381 Background: Early detection of melanoma is vital for treatment outcome and survival. Short-term sequential digital dermoscopic monitoring (ST-SDDM) involves the capture and assessment of dermoscopic images of one or more atypical melanocytic lesions (AMLs), at baseline and after four months, in order to detect early morphologic changes. Electrical impedance spectroscopy (EIS) is a diagnostic tool with high sensitivity for the detection of malignant melanocytic lesions. Objectives: The aim of this study was to assess whether EIS, in addition to ST-SDDM, could improve the selection of AMLs requiring surgery. Methods: In this retrospective descriptive study, 22 AMLs in 19 patients were monitored with both ST-SDDM and EIS. A modified EIS decision-making algorithm was established. AMLs were excised if any dermoscopic changes were seen and/or if the EIS score had increased significantly at follow-up. Statistical analyses were made including sensitivity, specificity, PPV and NPV. Results: A total of seven lesions (32%) were excised. Four lesions (57%) were excised solely because of dermoscopic changes including a 0.4 mm-thick melanoma and three benign nevi. Three benign lesions (43%) were excised because of increased EIS scores without any dermoscopic changes. The EIS scores at follow-up showed high variability as compared to the initial scores. Conclusion: The addition of EIS to ST-SDDM did not identify additional malignant lesions. There was no correlation between dermoscopic changes seen with ST-SDDM and increased EIS scores. Three histopathologically benign lesions were needlessly excised. Moreover, the low reproducibility and the possible interoperator variability of the method raised concerns. Hannah CederAlexandra Sjöholm HylénAnn-Marie Wennberg LarköJohn PaoliMattioli1885articledermoscopyatypical melanocytic lesionmelanomashort-term monitoringelectrical impedance spectroscopyDermatologyRL1-803ENDermatology Practical & Conceptual (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	dermoscopy atypical melanocytic lesion melanoma short-term monitoring electrical impedance spectroscopy Dermatology RL1-803
spellingShingle	dermoscopy atypical melanocytic lesion melanoma short-term monitoring electrical impedance spectroscopy Dermatology RL1-803 Hannah Ceder Alexandra Sjöholm Hylén Ann-Marie Wennberg Larkö John Paoli Evaluation of electrical impedance spectroscopy as an adjunct to dermoscopy in short-term monitoring of atypical melanocytic lesions
description	Background: Early detection of melanoma is vital for treatment outcome and survival. Short-term sequential digital dermoscopic monitoring (ST-SDDM) involves the capture and assessment of dermoscopic images of one or more atypical melanocytic lesions (AMLs), at baseline and after four months, in order to detect early morphologic changes. Electrical impedance spectroscopy (EIS) is a diagnostic tool with high sensitivity for the detection of malignant melanocytic lesions. Objectives: The aim of this study was to assess whether EIS, in addition to ST-SDDM, could improve the selection of AMLs requiring surgery. Methods: In this retrospective descriptive study, 22 AMLs in 19 patients were monitored with both ST-SDDM and EIS. A modified EIS decision-making algorithm was established. AMLs were excised if any dermoscopic changes were seen and/or if the EIS score had increased significantly at follow-up. Statistical analyses were made including sensitivity, specificity, PPV and NPV. Results: A total of seven lesions (32%) were excised. Four lesions (57%) were excised solely because of dermoscopic changes including a 0.4 mm-thick melanoma and three benign nevi. Three benign lesions (43%) were excised because of increased EIS scores without any dermoscopic changes. The EIS scores at follow-up showed high variability as compared to the initial scores. Conclusion: The addition of EIS to ST-SDDM did not identify additional malignant lesions. There was no correlation between dermoscopic changes seen with ST-SDDM and increased EIS scores. Three histopathologically benign lesions were needlessly excised. Moreover, the low reproducibility and the possible interoperator variability of the method raised concerns.
format	article
author	Hannah Ceder Alexandra Sjöholm Hylén Ann-Marie Wennberg Larkö John Paoli
author_facet	Hannah Ceder Alexandra Sjöholm Hylén Ann-Marie Wennberg Larkö John Paoli
author_sort	Hannah Ceder
title	Evaluation of electrical impedance spectroscopy as an adjunct to dermoscopy in short-term monitoring of atypical melanocytic lesions
title_short	Evaluation of electrical impedance spectroscopy as an adjunct to dermoscopy in short-term monitoring of atypical melanocytic lesions
title_full	Evaluation of electrical impedance spectroscopy as an adjunct to dermoscopy in short-term monitoring of atypical melanocytic lesions
title_fullStr	Evaluation of electrical impedance spectroscopy as an adjunct to dermoscopy in short-term monitoring of atypical melanocytic lesions
title_full_unstemmed	Evaluation of electrical impedance spectroscopy as an adjunct to dermoscopy in short-term monitoring of atypical melanocytic lesions
title_sort	evaluation of electrical impedance spectroscopy as an adjunct to dermoscopy in short-term monitoring of atypical melanocytic lesions
publisher	Mattioli1885
publishDate	2016
url	https://doaj.org/article/d461154a333541bdaa8f890f0b3f988e
work_keys_str_mv	AT hannahceder evaluationofelectricalimpedancespectroscopyasanadjuncttodermoscopyinshorttermmonitoringofatypicalmelanocyticlesions AT alexandrasjoholmhylen evaluationofelectricalimpedancespectroscopyasanadjuncttodermoscopyinshorttermmonitoringofatypicalmelanocyticlesions AT annmariewennberglarko evaluationofelectricalimpedancespectroscopyasanadjuncttodermoscopyinshorttermmonitoringofatypicalmelanocyticlesions AT johnpaoli evaluationofelectricalimpedancespectroscopyasanadjuncttodermoscopyinshorttermmonitoringofatypicalmelanocyticlesions
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Evaluation of electrical impedance spectroscopy as an adjunct to dermoscopy in short-term monitoring of atypical melanocytic lesions

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