Abundance of Lipopolysaccharide Heptosyltransferase I in Human Gut Microbiome and Its Association With Cardiovascular Disease and Liver Cirrhosis

Lipopolysaccharide (LPS) is a potent endotoxin on the outer membrane of gram-negative bacteria. Heptosyltransferase I (HpeI) takes part in the synthesis of LPS. In this study, we first collected the protein sequences of HpeI homologs from the human microbiome. The collected HpeI sequences was classi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shujin Lin, Hui Zhang, Xueke Wang, Ting Lin, Zihan Chen, Jingfeng Liu, Jianmin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	gut microbiota lipopolysaccharide heptosyltransferase health disease Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/d46176c13c564c8c93b6691b332baf06
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d46176c13c564c8c93b6691b332baf06
record_format	dspace
spelling	oai:doaj.org-article:d46176c13c564c8c93b6691b332baf062021-12-01T18:41:19ZAbundance of Lipopolysaccharide Heptosyltransferase I in Human Gut Microbiome and Its Association With Cardiovascular Disease and Liver Cirrhosis1664-302X10.3389/fmicb.2021.756976https://doaj.org/article/d46176c13c564c8c93b6691b332baf062021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.756976/fullhttps://doaj.org/toc/1664-302XLipopolysaccharide (LPS) is a potent endotoxin on the outer membrane of gram-negative bacteria. Heptosyltransferase I (HpeI) takes part in the synthesis of LPS. In this study, we first collected the protein sequences of HpeI homologs from the human microbiome. The collected HpeI sequences was classified based on sequence similarity, and seven clusters of HpeI were obtained. Among these clusters, proteins from Cluster 3 were abundant in the human mouth, while Clusters 1, 6, and 7 were abundant in the human gut. In addition, proteins from Cluster 1 were mainly from the order of Enterobacterales, while Cluster 6 and 7 were from Burkholderiales. The correlation analysis indicated that the total abundance of HpeIs was increased in patients with cardiovascular disease and liver cirrhosis, and HpeI in Cluster 1 contributed to this increase. These data suggest that HpeI homologs in Cluster 1 can be recognized as biomarkers for cardiovascular disease and liver cirrhosis, and that reducing the bacterial load in Cluster 1 may contribute to disease therapy.Shujin LinHui ZhangXueke WangTing LinZihan ChenJingfeng LiuJianmin WangFrontiers Media S.A.articlegut microbiotalipopolysaccharideheptosyltransferasehealthdiseaseMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gut microbiota lipopolysaccharide heptosyltransferase health disease Microbiology QR1-502
spellingShingle	gut microbiota lipopolysaccharide heptosyltransferase health disease Microbiology QR1-502 Shujin Lin Hui Zhang Xueke Wang Ting Lin Zihan Chen Jingfeng Liu Jianmin Wang Abundance of Lipopolysaccharide Heptosyltransferase I in Human Gut Microbiome and Its Association With Cardiovascular Disease and Liver Cirrhosis
description	Lipopolysaccharide (LPS) is a potent endotoxin on the outer membrane of gram-negative bacteria. Heptosyltransferase I (HpeI) takes part in the synthesis of LPS. In this study, we first collected the protein sequences of HpeI homologs from the human microbiome. The collected HpeI sequences was classified based on sequence similarity, and seven clusters of HpeI were obtained. Among these clusters, proteins from Cluster 3 were abundant in the human mouth, while Clusters 1, 6, and 7 were abundant in the human gut. In addition, proteins from Cluster 1 were mainly from the order of Enterobacterales, while Cluster 6 and 7 were from Burkholderiales. The correlation analysis indicated that the total abundance of HpeIs was increased in patients with cardiovascular disease and liver cirrhosis, and HpeI in Cluster 1 contributed to this increase. These data suggest that HpeI homologs in Cluster 1 can be recognized as biomarkers for cardiovascular disease and liver cirrhosis, and that reducing the bacterial load in Cluster 1 may contribute to disease therapy.
format	article
author	Shujin Lin Hui Zhang Xueke Wang Ting Lin Zihan Chen Jingfeng Liu Jianmin Wang
author_facet	Shujin Lin Hui Zhang Xueke Wang Ting Lin Zihan Chen Jingfeng Liu Jianmin Wang
author_sort	Shujin Lin
title	Abundance of Lipopolysaccharide Heptosyltransferase I in Human Gut Microbiome and Its Association With Cardiovascular Disease and Liver Cirrhosis
title_short	Abundance of Lipopolysaccharide Heptosyltransferase I in Human Gut Microbiome and Its Association With Cardiovascular Disease and Liver Cirrhosis
title_full	Abundance of Lipopolysaccharide Heptosyltransferase I in Human Gut Microbiome and Its Association With Cardiovascular Disease and Liver Cirrhosis
title_fullStr	Abundance of Lipopolysaccharide Heptosyltransferase I in Human Gut Microbiome and Its Association With Cardiovascular Disease and Liver Cirrhosis
title_full_unstemmed	Abundance of Lipopolysaccharide Heptosyltransferase I in Human Gut Microbiome and Its Association With Cardiovascular Disease and Liver Cirrhosis
title_sort	abundance of lipopolysaccharide heptosyltransferase i in human gut microbiome and its association with cardiovascular disease and liver cirrhosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d46176c13c564c8c93b6691b332baf06
work_keys_str_mv	AT shujinlin abundanceoflipopolysaccharideheptosyltransferaseiinhumangutmicrobiomeanditsassociationwithcardiovasculardiseaseandlivercirrhosis AT huizhang abundanceoflipopolysaccharideheptosyltransferaseiinhumangutmicrobiomeanditsassociationwithcardiovasculardiseaseandlivercirrhosis AT xuekewang abundanceoflipopolysaccharideheptosyltransferaseiinhumangutmicrobiomeanditsassociationwithcardiovasculardiseaseandlivercirrhosis AT tinglin abundanceoflipopolysaccharideheptosyltransferaseiinhumangutmicrobiomeanditsassociationwithcardiovasculardiseaseandlivercirrhosis AT zihanchen abundanceoflipopolysaccharideheptosyltransferaseiinhumangutmicrobiomeanditsassociationwithcardiovasculardiseaseandlivercirrhosis AT jingfengliu abundanceoflipopolysaccharideheptosyltransferaseiinhumangutmicrobiomeanditsassociationwithcardiovasculardiseaseandlivercirrhosis AT jianminwang abundanceoflipopolysaccharideheptosyltransferaseiinhumangutmicrobiomeanditsassociationwithcardiovasculardiseaseandlivercirrhosis
_version_	1718404723274416128

Abundance of Lipopolysaccharide Heptosyltransferase I in Human Gut Microbiome and Its Association With Cardiovascular Disease and Liver Cirrhosis

Ejemplares similares