Your verbal questions beginning with 'what' will rapidly deactivate the left prefrontal cortex of listeners

Abstract The left prefrontal cortex is essential for verbal communication. It remains uncertain at what timing, to what extent, and what type of phrase initiates left-hemispheric dominant prefrontal activation during comprehension of spoken sentences. We clarified this issue by measuring event-relat...

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Autores principales:	Hirotaka Iwaki, Masaki Sonoda, Shin-ichiro Osawa, Brian H. Silverstein, Takumi Mitsuhashi, Kazushi Ukishiro, Yutaro Takayama, Toshimune Kambara, Kazuo Kakinuma, Kyoko Suzuki, Teiji Tominaga, Nobukazu Nakasato, Masaki Iwasaki, Eishi Asano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d4625b80f725454f89eeee72a2096d29
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spelling	oai:doaj.org-article:d4625b80f725454f89eeee72a2096d292021-12-02T13:19:28ZYour verbal questions beginning with 'what' will rapidly deactivate the left prefrontal cortex of listeners10.1038/s41598-021-84610-12045-2322https://doaj.org/article/d4625b80f725454f89eeee72a2096d292021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84610-1https://doaj.org/toc/2045-2322Abstract The left prefrontal cortex is essential for verbal communication. It remains uncertain at what timing, to what extent, and what type of phrase initiates left-hemispheric dominant prefrontal activation during comprehension of spoken sentences. We clarified this issue by measuring event-related high-gamma activity during a task to respond to three-phrase questions configured in different orders. Questions beginning with a wh-interrogative deactivated the left posterior prefrontal cortex right after the 1st phrase offset and the anterior prefrontal cortex after the 2nd phrase offset. Left prefrontal high-gamma activity augmented subsequently and maximized around the 3rd phrase offset. Conversely, questions starting with a concrete phrase deactivated the right orbitofrontal region and then activated the left posterior prefrontal cortex after the 1st phrase offset. Regardless of sentence types, high-gamma activity emerged earlier, by one phrase, in the left posterior prefrontal than anterior prefrontal region. Sentences beginning with a wh-interrogative may initially deactivate the left prefrontal cortex to prioritize the bottom-up processing of upcoming auditory information. A concrete phrase may obliterate the inhibitory function of the right orbitofrontal region and facilitate top-down lexical prediction by the left prefrontal cortex. The left anterior prefrontal regions may be recruited for semantic integration of multiple concrete phrases.Hirotaka IwakiMasaki SonodaShin-ichiro OsawaBrian H. SilversteinTakumi MitsuhashiKazushi UkishiroYutaro TakayamaToshimune KambaraKazuo KakinumaKyoko SuzukiTeiji TominagaNobukazu NakasatoMasaki IwasakiEishi AsanoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hirotaka Iwaki Masaki Sonoda Shin-ichiro Osawa Brian H. Silverstein Takumi Mitsuhashi Kazushi Ukishiro Yutaro Takayama Toshimune Kambara Kazuo Kakinuma Kyoko Suzuki Teiji Tominaga Nobukazu Nakasato Masaki Iwasaki Eishi Asano Your verbal questions beginning with 'what' will rapidly deactivate the left prefrontal cortex of listeners
description	Abstract The left prefrontal cortex is essential for verbal communication. It remains uncertain at what timing, to what extent, and what type of phrase initiates left-hemispheric dominant prefrontal activation during comprehension of spoken sentences. We clarified this issue by measuring event-related high-gamma activity during a task to respond to three-phrase questions configured in different orders. Questions beginning with a wh-interrogative deactivated the left posterior prefrontal cortex right after the 1st phrase offset and the anterior prefrontal cortex after the 2nd phrase offset. Left prefrontal high-gamma activity augmented subsequently and maximized around the 3rd phrase offset. Conversely, questions starting with a concrete phrase deactivated the right orbitofrontal region and then activated the left posterior prefrontal cortex after the 1st phrase offset. Regardless of sentence types, high-gamma activity emerged earlier, by one phrase, in the left posterior prefrontal than anterior prefrontal region. Sentences beginning with a wh-interrogative may initially deactivate the left prefrontal cortex to prioritize the bottom-up processing of upcoming auditory information. A concrete phrase may obliterate the inhibitory function of the right orbitofrontal region and facilitate top-down lexical prediction by the left prefrontal cortex. The left anterior prefrontal regions may be recruited for semantic integration of multiple concrete phrases.
format	article
author	Hirotaka Iwaki Masaki Sonoda Shin-ichiro Osawa Brian H. Silverstein Takumi Mitsuhashi Kazushi Ukishiro Yutaro Takayama Toshimune Kambara Kazuo Kakinuma Kyoko Suzuki Teiji Tominaga Nobukazu Nakasato Masaki Iwasaki Eishi Asano
author_facet	Hirotaka Iwaki Masaki Sonoda Shin-ichiro Osawa Brian H. Silverstein Takumi Mitsuhashi Kazushi Ukishiro Yutaro Takayama Toshimune Kambara Kazuo Kakinuma Kyoko Suzuki Teiji Tominaga Nobukazu Nakasato Masaki Iwasaki Eishi Asano
author_sort	Hirotaka Iwaki
title	Your verbal questions beginning with 'what' will rapidly deactivate the left prefrontal cortex of listeners
title_short	Your verbal questions beginning with 'what' will rapidly deactivate the left prefrontal cortex of listeners
title_full	Your verbal questions beginning with 'what' will rapidly deactivate the left prefrontal cortex of listeners
title_fullStr	Your verbal questions beginning with 'what' will rapidly deactivate the left prefrontal cortex of listeners
title_full_unstemmed	Your verbal questions beginning with 'what' will rapidly deactivate the left prefrontal cortex of listeners
title_sort	your verbal questions beginning with 'what' will rapidly deactivate the left prefrontal cortex of listeners
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d4625b80f725454f89eeee72a2096d29
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Your verbal questions beginning with 'what' will rapidly deactivate the left prefrontal cortex of listeners

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