Driver oncogenes in Sub-Saharan African patients with non-small cell lung cancer

Barbara Legius,1 Sandra Van Den Broecke,1 Inge Muylle,1 Vincent Ninane1,2 1Department of Pulmonology, Centre Hospitalier Universitaire Saint Pierre, 2Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium Abstract: Non-small cell lung cancer can exhibit driver oncogenes, in...

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Autores principales:	Legius B, Van Den Broecke S, Muylle I, Ninane V
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Epidermal growth factor receptor (EGFR) mutation Anaplastic lymphoma kinase (ALK) translocation Africa Lung adenocarcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d464a303cfb346a08c223fa98621e3ea
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spelling	oai:doaj.org-article:d464a303cfb346a08c223fa98621e3ea2021-12-02T01:02:47ZDriver oncogenes in Sub-Saharan African patients with non-small cell lung cancer1179-2728https://doaj.org/article/d464a303cfb346a08c223fa98621e3ea2016-11-01T00:00:00Zhttps://www.dovepress.com/driver-oncogenes-in-sub-saharan-african-patients-with-non-small-cell-l-peer-reviewed-article-LCTThttps://doaj.org/toc/1179-2728Barbara Legius,1 Sandra Van Den Broecke,1 Inge Muylle,1 Vincent Ninane1,2 1Department of Pulmonology, Centre Hospitalier Universitaire Saint Pierre, 2Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium Abstract: Non-small cell lung cancer can exhibit driver oncogenes, including epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK), that are possible targets for therapy. The prevalence of these rearranged driver oncogenes is influenced by race, smoking habits, and gender. Most data come from Caucasian and Asian populations. To our knowledge, there is no literature available about the prevalence of driver oncogenes in Sub-Saharan Africa, where the tobacco epidemic is still in the early stage. In this small case series, 6 patients of Sub-Saharan African ethnicity with stage IV lung adenocarcinoma are described. EGFR mutation was present in 3/6 patients and ALK rearrangement in 1/6 patients. This incidence seems high but interestingly, all patients were non-smokers or light smokers. In this series, the high prevalence of driver oncogene was probably related to low smoking habits and these initial data in Sub-Saharan Africans suggest high prevalence of driver mutations for this reason. Keywords: epidermal growth factor receptor (EGFR) mutation, anaplastic lymphoma kinase (ALK) translocation, Africa, lung adenocarcinomaLegius BVan Den Broecke SMuylle INinane VDove Medical PressarticleEpidermal growth factor receptor (EGFR) mutationAnaplastic lymphoma kinase (ALK) translocationAfricaLung adenocarcinomaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENLung Cancer: Targets and Therapy, Vol Volume 7, Pp 149-152 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Epidermal growth factor receptor (EGFR) mutation Anaplastic lymphoma kinase (ALK) translocation Africa Lung adenocarcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Epidermal growth factor receptor (EGFR) mutation Anaplastic lymphoma kinase (ALK) translocation Africa Lung adenocarcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Legius B Van Den Broecke S Muylle I Ninane V Driver oncogenes in Sub-Saharan African patients with non-small cell lung cancer
description	Barbara Legius,1 Sandra Van Den Broecke,1 Inge Muylle,1 Vincent Ninane1,2 1Department of Pulmonology, Centre Hospitalier Universitaire Saint Pierre, 2Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium Abstract: Non-small cell lung cancer can exhibit driver oncogenes, including epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK), that are possible targets for therapy. The prevalence of these rearranged driver oncogenes is influenced by race, smoking habits, and gender. Most data come from Caucasian and Asian populations. To our knowledge, there is no literature available about the prevalence of driver oncogenes in Sub-Saharan Africa, where the tobacco epidemic is still in the early stage. In this small case series, 6 patients of Sub-Saharan African ethnicity with stage IV lung adenocarcinoma are described. EGFR mutation was present in 3/6 patients and ALK rearrangement in 1/6 patients. This incidence seems high but interestingly, all patients were non-smokers or light smokers. In this series, the high prevalence of driver oncogene was probably related to low smoking habits and these initial data in Sub-Saharan Africans suggest high prevalence of driver mutations for this reason. Keywords: epidermal growth factor receptor (EGFR) mutation, anaplastic lymphoma kinase (ALK) translocation, Africa, lung adenocarcinoma
format	article
author	Legius B Van Den Broecke S Muylle I Ninane V
author_facet	Legius B Van Den Broecke S Muylle I Ninane V
author_sort	Legius B
title	Driver oncogenes in Sub-Saharan African patients with non-small cell lung cancer
title_short	Driver oncogenes in Sub-Saharan African patients with non-small cell lung cancer
title_full	Driver oncogenes in Sub-Saharan African patients with non-small cell lung cancer
title_fullStr	Driver oncogenes in Sub-Saharan African patients with non-small cell lung cancer
title_full_unstemmed	Driver oncogenes in Sub-Saharan African patients with non-small cell lung cancer
title_sort	driver oncogenes in sub-saharan african patients with non-small cell lung cancer
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/d464a303cfb346a08c223fa98621e3ea
work_keys_str_mv	AT legiusb driveroncogenesinsubsaharanafricanpatientswithnonsmallcelllungcancer AT vandenbroeckes driveroncogenesinsubsaharanafricanpatientswithnonsmallcelllungcancer AT muyllei driveroncogenesinsubsaharanafricanpatientswithnonsmallcelllungcancer AT ninanev driveroncogenesinsubsaharanafricanpatientswithnonsmallcelllungcancer
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Driver oncogenes in Sub-Saharan African patients with non-small cell lung cancer

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