Cross sectional survey of influenza antibodies before and during the 2009 pandemic in Shenzhen, China.

Much information is available for the 2009 H1N1 influenza immunity response, but little is known about the antibody change in seasonal influenza before and during the novel influenza A pandemic. In this study, we conducted a cross-sectional serological survey of 4 types of major seasonal influenza i...

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Autores principales:	Chun-Li Wu, Juan Lu, Maggie Haitian Wang, Xing Lv, Ying Chen, Hsiang-fu Kung, Benny Zee, Xiao-wen Cheng, Ming-Liang He
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d466fe3596884e05b30fa3e020cc0216
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spelling	oai:doaj.org-article:d466fe3596884e05b30fa3e020cc02162021-11-18T07:59:42ZCross sectional survey of influenza antibodies before and during the 2009 pandemic in Shenzhen, China.1932-620310.1371/journal.pone.0053847https://doaj.org/article/d466fe3596884e05b30fa3e020cc02162013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23382854/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Much information is available for the 2009 H1N1 influenza immunity response, but little is known about the antibody change in seasonal influenza before and during the novel influenza A pandemic. In this study, we conducted a cross-sectional serological survey of 4 types of major seasonal influenza in March and September 2009 on a full range of age groups, to investigate seasonal influenza immunity response before and during the outbreak of the sH1N1 influenza in Shenzhen - the largest migration city in China. We found that the 0-5 age group had an increased antibody level for all types of seasonal influenza during the pandemic compared to the pre-outbreak level, in contrast with almost all other age groups, in which the antibody level decreased. Also, distinct from the antibodies of A/H3N2, B/Yamagata and B/Victoria that decreased significantly during the 2009 H1N1 pandemic, the antibody of A/H1N1 showed no statistical difference from the pre-outbreak level. The results suggest that the antibodies against the 2009 sH1N1 cross-reacted with seasonal H1N1. Moreover, the 0-5 age group was under attack by both seasonal and 2009 H1N1 influenza during the pandemic, hence vaccination merely against a new strain of flu might not be enough to protect the youngest group.Chun-Li WuJuan LuMaggie Haitian WangXing LvYing ChenHsiang-fu KungBenny ZeeXiao-wen ChengMing-Liang HeMing-Liang HePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e53847 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chun-Li Wu Juan Lu Maggie Haitian Wang Xing Lv Ying Chen Hsiang-fu Kung Benny Zee Xiao-wen Cheng Ming-Liang He Ming-Liang He Cross sectional survey of influenza antibodies before and during the 2009 pandemic in Shenzhen, China.
description	Much information is available for the 2009 H1N1 influenza immunity response, but little is known about the antibody change in seasonal influenza before and during the novel influenza A pandemic. In this study, we conducted a cross-sectional serological survey of 4 types of major seasonal influenza in March and September 2009 on a full range of age groups, to investigate seasonal influenza immunity response before and during the outbreak of the sH1N1 influenza in Shenzhen - the largest migration city in China. We found that the 0-5 age group had an increased antibody level for all types of seasonal influenza during the pandemic compared to the pre-outbreak level, in contrast with almost all other age groups, in which the antibody level decreased. Also, distinct from the antibodies of A/H3N2, B/Yamagata and B/Victoria that decreased significantly during the 2009 H1N1 pandemic, the antibody of A/H1N1 showed no statistical difference from the pre-outbreak level. The results suggest that the antibodies against the 2009 sH1N1 cross-reacted with seasonal H1N1. Moreover, the 0-5 age group was under attack by both seasonal and 2009 H1N1 influenza during the pandemic, hence vaccination merely against a new strain of flu might not be enough to protect the youngest group.
format	article
author	Chun-Li Wu Juan Lu Maggie Haitian Wang Xing Lv Ying Chen Hsiang-fu Kung Benny Zee Xiao-wen Cheng Ming-Liang He Ming-Liang He
author_facet	Chun-Li Wu Juan Lu Maggie Haitian Wang Xing Lv Ying Chen Hsiang-fu Kung Benny Zee Xiao-wen Cheng Ming-Liang He Ming-Liang He
author_sort	Chun-Li Wu
title	Cross sectional survey of influenza antibodies before and during the 2009 pandemic in Shenzhen, China.
title_short	Cross sectional survey of influenza antibodies before and during the 2009 pandemic in Shenzhen, China.
title_full	Cross sectional survey of influenza antibodies before and during the 2009 pandemic in Shenzhen, China.
title_fullStr	Cross sectional survey of influenza antibodies before and during the 2009 pandemic in Shenzhen, China.
title_full_unstemmed	Cross sectional survey of influenza antibodies before and during the 2009 pandemic in Shenzhen, China.
title_sort	cross sectional survey of influenza antibodies before and during the 2009 pandemic in shenzhen, china.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/d466fe3596884e05b30fa3e020cc0216
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Cross sectional survey of influenza antibodies before and during the 2009 pandemic in Shenzhen, China.

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