Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia

Loss of Fancd2 leads to replication stress intolerance and Fanconi Anemia, where haematopoietic stem cell (HSC) function is compromised. Here, the authors show that Lnk/Sh2b3 loss restores HSC proliferation and survival in Fancd2 knockout mice and ameliorates replication stress in a cytokine/JAK2 si...

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Autores principales:	Joanna Balcerek, Jing Jiang, Yang Li, Qinqin Jiang, Nicholas Holdreith, Brijendra Singh, Vemika Chandra, Kaosheng Lv, Jian-gang Ren, Krasimira Rozenova, Weihua Li, Roger A. Greenberg, Wei Tong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d467920db1af4931b19c732f10975998
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spelling	oai:doaj.org-article:d467920db1af4931b19c732f109759982021-12-02T15:34:19ZLnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia10.1038/s41467-018-06380-12041-1723https://doaj.org/article/d467920db1af4931b19c732f109759982018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06380-1https://doaj.org/toc/2041-1723Loss of Fancd2 leads to replication stress intolerance and Fanconi Anemia, where haematopoietic stem cell (HSC) function is compromised. Here, the authors show that Lnk/Sh2b3 loss restores HSC proliferation and survival in Fancd2 knockout mice and ameliorates replication stress in a cytokine/JAK2 signaling dependent manner.Joanna BalcerekJing JiangYang LiQinqin JiangNicholas HoldreithBrijendra SinghVemika ChandraKaosheng LvJian-gang RenKrasimira RozenovaWeihua LiRoger A. GreenbergWei TongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joanna Balcerek Jing Jiang Yang Li Qinqin Jiang Nicholas Holdreith Brijendra Singh Vemika Chandra Kaosheng Lv Jian-gang Ren Krasimira Rozenova Weihua Li Roger A. Greenberg Wei Tong Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia
description	Loss of Fancd2 leads to replication stress intolerance and Fanconi Anemia, where haematopoietic stem cell (HSC) function is compromised. Here, the authors show that Lnk/Sh2b3 loss restores HSC proliferation and survival in Fancd2 knockout mice and ameliorates replication stress in a cytokine/JAK2 signaling dependent manner.
format	article
author	Joanna Balcerek Jing Jiang Yang Li Qinqin Jiang Nicholas Holdreith Brijendra Singh Vemika Chandra Kaosheng Lv Jian-gang Ren Krasimira Rozenova Weihua Li Roger A. Greenberg Wei Tong
author_facet	Joanna Balcerek Jing Jiang Yang Li Qinqin Jiang Nicholas Holdreith Brijendra Singh Vemika Chandra Kaosheng Lv Jian-gang Ren Krasimira Rozenova Weihua Li Roger A. Greenberg Wei Tong
author_sort	Joanna Balcerek
title	Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia
title_short	Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia
title_full	Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia
title_fullStr	Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia
title_full_unstemmed	Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia
title_sort	lnk/sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in fancd2 deficient fanconi anemia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d467920db1af4931b19c732f10975998
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Lnk/Sh2b3 deficiency restores hematopoietic stem cell function and genome integrity in Fancd2 deficient Fanconi anemia

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