Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients

Overnutrition has been linked to increased risk of cancer. Here, the authors show that exceeding nutrients suppress Enoyl-CoA hydratase-1 (ECHS1) activity by inducing its acetylation resulting in accumulation of fatty acids and branched-chain amino acids and oncogenic mTOR activation.

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Autores principales:	Ya-Kun Zhang, Yuan-Yuan Qu, Yan Lin, Xiao-Hui Wu, Hou-Zao Chen, Xu Wang, Kai-Qiang Zhou, Yun Wei, Fushen Guo, Cui-Fang Yao, Xia-Di He, Li-Xia Liu, Chen Yang, Zong-Yuan Guan, Shi-Dong Wang, Jianyuan Zhao, De-Pei Liu, Shi-Min Zhao, Wei Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d46815d31f134af6aa2e2ea7608d395c
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spelling	oai:doaj.org-article:d46815d31f134af6aa2e2ea7608d395c2021-12-02T14:40:25ZEnoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients10.1038/s41467-017-00489-52041-1723https://doaj.org/article/d46815d31f134af6aa2e2ea7608d395c2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00489-5https://doaj.org/toc/2041-1723Overnutrition has been linked to increased risk of cancer. Here, the authors show that exceeding nutrients suppress Enoyl-CoA hydratase-1 (ECHS1) activity by inducing its acetylation resulting in accumulation of fatty acids and branched-chain amino acids and oncogenic mTOR activation.Ya-Kun ZhangYuan-Yuan QuYan LinXiao-Hui WuHou-Zao ChenXu WangKai-Qiang ZhouYun WeiFushen GuoCui-Fang YaoXia-Di HeLi-Xia LiuChen YangZong-Yuan GuanShi-Dong WangJianyuan ZhaoDe-Pei LiuShi-Min ZhaoWei XuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ya-Kun Zhang Yuan-Yuan Qu Yan Lin Xiao-Hui Wu Hou-Zao Chen Xu Wang Kai-Qiang Zhou Yun Wei Fushen Guo Cui-Fang Yao Xia-Di He Li-Xia Liu Chen Yang Zong-Yuan Guan Shi-Dong Wang Jianyuan Zhao De-Pei Liu Shi-Min Zhao Wei Xu Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
description	Overnutrition has been linked to increased risk of cancer. Here, the authors show that exceeding nutrients suppress Enoyl-CoA hydratase-1 (ECHS1) activity by inducing its acetylation resulting in accumulation of fatty acids and branched-chain amino acids and oncogenic mTOR activation.
format	article
author	Ya-Kun Zhang Yuan-Yuan Qu Yan Lin Xiao-Hui Wu Hou-Zao Chen Xu Wang Kai-Qiang Zhou Yun Wei Fushen Guo Cui-Fang Yao Xia-Di He Li-Xia Liu Chen Yang Zong-Yuan Guan Shi-Dong Wang Jianyuan Zhao De-Pei Liu Shi-Min Zhao Wei Xu
author_facet	Ya-Kun Zhang Yuan-Yuan Qu Yan Lin Xiao-Hui Wu Hou-Zao Chen Xu Wang Kai-Qiang Zhou Yun Wei Fushen Guo Cui-Fang Yao Xia-Di He Li-Xia Liu Chen Yang Zong-Yuan Guan Shi-Dong Wang Jianyuan Zhao De-Pei Liu Shi-Min Zhao Wei Xu
author_sort	Ya-Kun Zhang
title	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
title_short	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
title_full	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
title_fullStr	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
title_full_unstemmed	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
title_sort	enoyl-coa hydratase-1 regulates mtor signaling and apoptosis by sensing nutrients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d46815d31f134af6aa2e2ea7608d395c
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Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients

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