The γ-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells

Corvaisier et al discover that γ-tubulin and replication protein PCNA forms a complex and that this facilitates recruitment of PCNA to chromatin both during cell division and during the DSB repair response. They identify a PCNA binding motif in γ-tubulin, which when mutated affects replication fork...

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Autores principales:	Matthieu Corvaisier, Jingkai Zhou, Darina Malycheva, Nicola Cornella, Dimitrios Chioureas, Nina M. S. Gustafsson, Catalina Ana Rosselló, Silvia Ayora, Tongbin Li, Kristina Ekström-Holka, Karin Jirström, Lisa Lindström, Maria Alvarado-Kristensson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d469a9dc7bd3404abb6d4c62729c07e8
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spelling	oai:doaj.org-article:d469a9dc7bd3404abb6d4c62729c07e82021-12-02T17:45:20ZThe γ-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells10.1038/s42003-021-02280-12399-3642https://doaj.org/article/d469a9dc7bd3404abb6d4c62729c07e82021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02280-1https://doaj.org/toc/2399-3642Corvaisier et al discover that γ-tubulin and replication protein PCNA forms a complex and that this facilitates recruitment of PCNA to chromatin both during cell division and during the DSB repair response. They identify a PCNA binding motif in γ-tubulin, which when mutated affects replication fork progression, providing insights into the role of the nuclear γ-tubulin meshwork.Matthieu CorvaisierJingkai ZhouDarina MalychevaNicola CornellaDimitrios ChioureasNina M. S. GustafssonCatalina Ana RossellóSilvia AyoraTongbin LiKristina Ekström-HolkaKarin JirströmLisa LindströmMaria Alvarado-KristenssonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Matthieu Corvaisier Jingkai Zhou Darina Malycheva Nicola Cornella Dimitrios Chioureas Nina M. S. Gustafsson Catalina Ana Rosselló Silvia Ayora Tongbin Li Kristina Ekström-Holka Karin Jirström Lisa Lindström Maria Alvarado-Kristensson The γ-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells
description	Corvaisier et al discover that γ-tubulin and replication protein PCNA forms a complex and that this facilitates recruitment of PCNA to chromatin both during cell division and during the DSB repair response. They identify a PCNA binding motif in γ-tubulin, which when mutated affects replication fork progression, providing insights into the role of the nuclear γ-tubulin meshwork.
format	article
author	Matthieu Corvaisier Jingkai Zhou Darina Malycheva Nicola Cornella Dimitrios Chioureas Nina M. S. Gustafsson Catalina Ana Rosselló Silvia Ayora Tongbin Li Kristina Ekström-Holka Karin Jirström Lisa Lindström Maria Alvarado-Kristensson
author_facet	Matthieu Corvaisier Jingkai Zhou Darina Malycheva Nicola Cornella Dimitrios Chioureas Nina M. S. Gustafsson Catalina Ana Rosselló Silvia Ayora Tongbin Li Kristina Ekström-Holka Karin Jirström Lisa Lindström Maria Alvarado-Kristensson
author_sort	Matthieu Corvaisier
title	The γ-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells
title_short	The γ-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells
title_full	The γ-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells
title_fullStr	The γ-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells
title_full_unstemmed	The γ-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells
title_sort	γ-tubulin meshwork assists in the recruitment of pcna to chromatin in mammalian cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d469a9dc7bd3404abb6d4c62729c07e8
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The γ-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells

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