High expression of PARD3 predicts poor prognosis in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) is one of the most commonly cancers with poor prognosis and drug response. Identifying accurate therapeutic targets would facilitate precision treatment and prolong survival for HCC. In this study, we analyzed liver hepatocellular carcinoma (LIHC) RNA sequenci...

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Autores principales:	Songwei Li, Jian Huang, Fan Yang, Haiping Zeng, Yuyun Tong, Kejia Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d46a0ce8208a4ba9aedc4eebbc834fa2
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spelling	oai:doaj.org-article:d46a0ce8208a4ba9aedc4eebbc834fa22021-12-02T15:00:25ZHigh expression of PARD3 predicts poor prognosis in hepatocellular carcinoma10.1038/s41598-021-90507-w2045-2322https://doaj.org/article/d46a0ce8208a4ba9aedc4eebbc834fa22021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90507-whttps://doaj.org/toc/2045-2322Abstract Hepatocellular carcinoma (HCC) is one of the most commonly cancers with poor prognosis and drug response. Identifying accurate therapeutic targets would facilitate precision treatment and prolong survival for HCC. In this study, we analyzed liver hepatocellular carcinoma (LIHC) RNA sequencing (RNA-seq) data from The Cancer Genome Atlas (TCGA), and identified PARD3 as one of the most significantly differentially expressed genes (DEGs). Then, we investigated the relationship between PARD3 and outcomes of HCC, and assessed predictive capacity. Moreover, we performed functional enrichment and immune infiltration analysis to evaluate functional networks related to PARD3 in HCC and explore its role in tumor immunity. PARD3 expression levels in 371 HCC tissues were dramatically higher than those in 50 paired adjacent liver tissues (p < 0.001). High PARD3 expression was associated with poor clinicopathologic feathers, such as advanced pathologic stage (p = 0.002), vascular invasion (p = 0.012) and TP53 mutation (p = 0.009). Elevated PARD3 expression also correlated with lower overall survival (OS, HR = 2.08, 95% CI = 1.45–2.98, p < 0.001) and disease-specific survival (DSS, HR = 2.00, 95% CI = 1.27–3.16, p = 0.003). 242 up-regulated and 71 down-regulated genes showed significant association with PARD3 expression, which were involved in genomic instability, response to metal ions, and metabolisms. PARD3 is involved in diverse immune infiltration levels in HCC, especially negatively related to dendritic cells (DCs), cytotoxic cells, and plasmacytoid dendritic cells (pDCs). Altogether, PARD3 could be a potential prognostic biomarker and therapeutic target of HCC.Songwei LiJian HuangFan YangHaiping ZengYuyun TongKejia LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Songwei Li Jian Huang Fan Yang Haiping Zeng Yuyun Tong Kejia Li High expression of PARD3 predicts poor prognosis in hepatocellular carcinoma
description	Abstract Hepatocellular carcinoma (HCC) is one of the most commonly cancers with poor prognosis and drug response. Identifying accurate therapeutic targets would facilitate precision treatment and prolong survival for HCC. In this study, we analyzed liver hepatocellular carcinoma (LIHC) RNA sequencing (RNA-seq) data from The Cancer Genome Atlas (TCGA), and identified PARD3 as one of the most significantly differentially expressed genes (DEGs). Then, we investigated the relationship between PARD3 and outcomes of HCC, and assessed predictive capacity. Moreover, we performed functional enrichment and immune infiltration analysis to evaluate functional networks related to PARD3 in HCC and explore its role in tumor immunity. PARD3 expression levels in 371 HCC tissues were dramatically higher than those in 50 paired adjacent liver tissues (p < 0.001). High PARD3 expression was associated with poor clinicopathologic feathers, such as advanced pathologic stage (p = 0.002), vascular invasion (p = 0.012) and TP53 mutation (p = 0.009). Elevated PARD3 expression also correlated with lower overall survival (OS, HR = 2.08, 95% CI = 1.45–2.98, p < 0.001) and disease-specific survival (DSS, HR = 2.00, 95% CI = 1.27–3.16, p = 0.003). 242 up-regulated and 71 down-regulated genes showed significant association with PARD3 expression, which were involved in genomic instability, response to metal ions, and metabolisms. PARD3 is involved in diverse immune infiltration levels in HCC, especially negatively related to dendritic cells (DCs), cytotoxic cells, and plasmacytoid dendritic cells (pDCs). Altogether, PARD3 could be a potential prognostic biomarker and therapeutic target of HCC.
format	article
author	Songwei Li Jian Huang Fan Yang Haiping Zeng Yuyun Tong Kejia Li
author_facet	Songwei Li Jian Huang Fan Yang Haiping Zeng Yuyun Tong Kejia Li
author_sort	Songwei Li
title	High expression of PARD3 predicts poor prognosis in hepatocellular carcinoma
title_short	High expression of PARD3 predicts poor prognosis in hepatocellular carcinoma
title_full	High expression of PARD3 predicts poor prognosis in hepatocellular carcinoma
title_fullStr	High expression of PARD3 predicts poor prognosis in hepatocellular carcinoma
title_full_unstemmed	High expression of PARD3 predicts poor prognosis in hepatocellular carcinoma
title_sort	high expression of pard3 predicts poor prognosis in hepatocellular carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d46a0ce8208a4ba9aedc4eebbc834fa2
work_keys_str_mv	AT songweili highexpressionofpard3predictspoorprognosisinhepatocellularcarcinoma AT jianhuang highexpressionofpard3predictspoorprognosisinhepatocellularcarcinoma AT fanyang highexpressionofpard3predictspoorprognosisinhepatocellularcarcinoma AT haipingzeng highexpressionofpard3predictspoorprognosisinhepatocellularcarcinoma AT yuyuntong highexpressionofpard3predictspoorprognosisinhepatocellularcarcinoma AT kejiali highexpressionofpard3predictspoorprognosisinhepatocellularcarcinoma
_version_	1718389166621851648

High expression of PARD3 predicts poor prognosis in hepatocellular carcinoma

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