Diagnostic Evaluation of 99mTc-TRODAT-1 SPECT in Parkinsonism

Background Parkinsonism as a group of movement disorders, exhibit similar clinical presentation. Therefore, clinically differentiating these diseases is difficult. We investigated the diagnostic value of 99m Tc-TRODAT-1 SPECT in this setting. Due to the fact that this modality has some limitations i...

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Autores principales:	Zahra Babaei Aghdam, Safa Najmi Tabrizi, Amin Arasteh, Mohammad Khalafi, Morteza Ghojazadeh, Babak Mahmoudian
Formato:	article
Lenguaje:	EN
Publicado:	Tabriz University of Medical Sciences Press 2021
Materias:	parkinsonian disorders single photon emission computed tomography 99mtc-trodat-1 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d46b51a371a445f29bccd0cf9c26361e
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spelling	oai:doaj.org-article:d46b51a371a445f29bccd0cf9c26361e2021-12-01T06:08:09ZDiagnostic Evaluation of 99mTc-TRODAT-1 SPECT in Parkinsonism2717-061610.34172/jrcm.2021.036https://doaj.org/article/d46b51a371a445f29bccd0cf9c26361e2021-11-01T00:00:00Zhttps://jrcm.tbzmed.ac.ir/PDF/jrcm-9-36.pdfhttps://doaj.org/toc/2717-0616Background Parkinsonism as a group of movement disorders, exhibit similar clinical presentation. Therefore, clinically differentiating these diseases is difficult. We investigated the diagnostic value of 99m Tc-TRODAT-1 SPECT in this setting. Due to the fact that this modality has some limitations in imaging small organs like the sub-regions of basal ganglia, we also evaluated the use of anatomical MR imaging along with functional SPECT imaging in parkinsonism. Methods This follow-up diagnostic test evaluation study was performed with 40 patients with the clinical presentation of parkinsonism, and 10 healthy subjects as controls. After administration of the radiopharmaceutical, SPECT images were acquired, then co-registered on MRI. Uptake values were evaluated in basal ganglia semi-quantitatively. Results In this study, 99mTc-TRODAT-1 SPECT was able to differentiate essential tremor and healthy subjects from progressive supranuclear palsy (PSP) and Parkinson’s disease (PD) with a sensitivity of 76.47% and specificity of 100% at a cut-off of 0.53; however, findings were not significant in differentiation of PD from PSP (p >0.05), and the results were similar in SPECT and co-registered MRI/SPECT images. In evaluation of the uptake pattern in basal ganglia, the lateralization of decreased uptake was only seen in PD; and in PSP, the dysfunction was bilateral in all patients. Conclusion 99mTc-TRODAT-1 SPECT is sensitive and specific in diagnosing basal ganglia dysfunction; however, 99mTc-TRODAT-1 SPECT alone or co-registration on MRI are not adequate in differentiation of the etiologies of basal ganglia dysfunction.Zahra Babaei AghdamSafa Najmi TabriziAmin ArastehMohammad KhalafiMorteza GhojazadehBabak MahmoudianTabriz University of Medical Sciences Pressarticleparkinsonian disorderssingle photon emission computed tomography99mtc-trodat-1Medicine (General)R5-920ENJournal of Research in Clinical Medicine, Vol 9, Iss 1, Pp 36-36 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	parkinsonian disorders single photon emission computed tomography 99mtc-trodat-1 Medicine (General) R5-920
spellingShingle	parkinsonian disorders single photon emission computed tomography 99mtc-trodat-1 Medicine (General) R5-920 Zahra Babaei Aghdam Safa Najmi Tabrizi Amin Arasteh Mohammad Khalafi Morteza Ghojazadeh Babak Mahmoudian Diagnostic Evaluation of 99mTc-TRODAT-1 SPECT in Parkinsonism
description	Background Parkinsonism as a group of movement disorders, exhibit similar clinical presentation. Therefore, clinically differentiating these diseases is difficult. We investigated the diagnostic value of 99m Tc-TRODAT-1 SPECT in this setting. Due to the fact that this modality has some limitations in imaging small organs like the sub-regions of basal ganglia, we also evaluated the use of anatomical MR imaging along with functional SPECT imaging in parkinsonism. Methods This follow-up diagnostic test evaluation study was performed with 40 patients with the clinical presentation of parkinsonism, and 10 healthy subjects as controls. After administration of the radiopharmaceutical, SPECT images were acquired, then co-registered on MRI. Uptake values were evaluated in basal ganglia semi-quantitatively. Results In this study, 99mTc-TRODAT-1 SPECT was able to differentiate essential tremor and healthy subjects from progressive supranuclear palsy (PSP) and Parkinson’s disease (PD) with a sensitivity of 76.47% and specificity of 100% at a cut-off of 0.53; however, findings were not significant in differentiation of PD from PSP (p >0.05), and the results were similar in SPECT and co-registered MRI/SPECT images. In evaluation of the uptake pattern in basal ganglia, the lateralization of decreased uptake was only seen in PD; and in PSP, the dysfunction was bilateral in all patients. Conclusion 99mTc-TRODAT-1 SPECT is sensitive and specific in diagnosing basal ganglia dysfunction; however, 99mTc-TRODAT-1 SPECT alone or co-registration on MRI are not adequate in differentiation of the etiologies of basal ganglia dysfunction.
format	article
author	Zahra Babaei Aghdam Safa Najmi Tabrizi Amin Arasteh Mohammad Khalafi Morteza Ghojazadeh Babak Mahmoudian
author_facet	Zahra Babaei Aghdam Safa Najmi Tabrizi Amin Arasteh Mohammad Khalafi Morteza Ghojazadeh Babak Mahmoudian
author_sort	Zahra Babaei Aghdam
title	Diagnostic Evaluation of 99mTc-TRODAT-1 SPECT in Parkinsonism
title_short	Diagnostic Evaluation of 99mTc-TRODAT-1 SPECT in Parkinsonism
title_full	Diagnostic Evaluation of 99mTc-TRODAT-1 SPECT in Parkinsonism
title_fullStr	Diagnostic Evaluation of 99mTc-TRODAT-1 SPECT in Parkinsonism
title_full_unstemmed	Diagnostic Evaluation of 99mTc-TRODAT-1 SPECT in Parkinsonism
title_sort	diagnostic evaluation of 99mtc-trodat-1 spect in parkinsonism
publisher	Tabriz University of Medical Sciences Press
publishDate	2021
url	https://doaj.org/article/d46b51a371a445f29bccd0cf9c26361e
work_keys_str_mv	AT zahrababaeiaghdam diagnosticevaluationof99mtctrodat1spectinparkinsonism AT safanajmitabrizi diagnosticevaluationof99mtctrodat1spectinparkinsonism AT aminarasteh diagnosticevaluationof99mtctrodat1spectinparkinsonism AT mohammadkhalafi diagnosticevaluationof99mtctrodat1spectinparkinsonism AT mortezaghojazadeh diagnosticevaluationof99mtctrodat1spectinparkinsonism AT babakmahmoudian diagnosticevaluationof99mtctrodat1spectinparkinsonism
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Diagnostic Evaluation of 99mTc-TRODAT-1 SPECT in Parkinsonism

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