Dual delayed feedback provides sensitivity and robustness to the NF-κB signaling module.
Many cellular stress-responsive signaling systems exhibit highly dynamic behavior with oscillatory features mediated by delayed negative feedback loops. What remains unclear is whether oscillatory behavior is the basis for a signaling code based on frequency modulation (FM) or whether the negative f...
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Main Authors: | Diane M Longo, Jangir Selimkhanov, Jeffrey D Kearns, Jeff Hasty, Alexander Hoffmann, Lev S Tsimring |
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Format: | article |
Language: | EN |
Published: |
Public Library of Science (PLoS)
2013
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Online Access: | https://doaj.org/article/d46deef5c1d24267890fa77561ef3eea |
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