Presence and consequence of tooth periapical radiolucency in patients with cirrhosis
Lea Ladegaard Grønkjær,1 Palle Holmstrup,2 Søren Schou,3 Kristoffer Schwartz,4 Johanne Kongstad,2 Peter Jepsen,1,5 Hendrik Vilstrup1 1Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, 2Section of Periodontology, Microbiology, and Commu...
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Dove Medical Press
2016
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oai:doaj.org-article:d46f28b7eda34f4eb21f5bdcb76059882021-12-02T05:51:56ZPresence and consequence of tooth periapical radiolucency in patients with cirrhosis1179-1535https://doaj.org/article/d46f28b7eda34f4eb21f5bdcb76059882016-09-01T00:00:00Zhttps://www.dovepress.com/presence-and-consequence-of-tooth-periapical-radiolucency-in-patients--peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535Lea Ladegaard Grønkjær,1 Palle Holmstrup,2 Søren Schou,3 Kristoffer Schwartz,4 Johanne Kongstad,2 Peter Jepsen,1,5 Hendrik Vilstrup1 1Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, 2Section of Periodontology, Microbiology, and Community Dentistry, Department of Odontology, Faculty of Health and Medical Sciences, 3Section for Oral and Maxillofacial Surgery, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 4Department of Oral and Maxillofacial Surgery, 5Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark Background: Periapical radiolucency is the radiographic sign of inflammatory bone lesions around the apex of the tooth. We determined the prevalence and predictors of periapical radiolucency in patients with cirrhosis and the association with systemic inflammation status and cirrhosis-related complications.Methods: A total of 110 cirrhosis patients were consecutively enrolled. Periapical radiolucency was defined as the presence of radiolucency or widening of the periapical periodontal ligament space to more than twice the normal width. Predictors of periapical radiolucency and the association with systemic inflammation markers and cirrhosis-related complications were explored by univariable and multivariable logistic regression analyses.Results: Periapical radiolucency was present in one or more teeth in 46% of the patients. Strong predictors were gross caries (odds ratio [OR] 3.12, 95% confidence interval [CI] 1.43–6.79) and severe periodontitis (OR 3.98, 95% CI 1.04–15.20). Also old age (OR 1.10, 95% CI 1.01–1.19) and smoking (OR 3.24, 95% CI 1.02–17.62) were predictors. However, cirrhosis etiology (alcoholic vs nonalcoholic) or severity (Model of End-Stage Liver Disease score) were not predictors. The patients with periapical radiolucency had higher C-reactive protein (15.8 mg/L vs 8.1 mg/L, P=0.02) and lower albumin contents (25 g/L vs 28 g/L, P=0.04) than those without. Furthermore, the patients with periapical radiolucency had a higher prevalence of cirrhosis-related complications such as ascites, hepatic encephalopathy, and/or variceal ­bleeding (46% vs 27%, P=0.05).Conclusion: Periapical radiolucency is often present as an element of poor oral health status and likely has an adverse clinical significance, which should motivate diagnostic and clinical attention to the findings. Keywords: apical periodontitis, cirrhosis, C-reactive protein, inflammation status, MELD score, periapical radiolucencyGrønkjær LLHolmstrup PSchou SSchwartz KKongstad JJepsen PVilstrup HDove Medical PressarticleApical periodontitiscirrhosisC-reactive proteininflammation statusMELD scoreperiapical radiolucency.Diseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol Volume 8, Pp 97-103 (2016) |
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DOAJ |
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EN |
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Apical periodontitis cirrhosis C-reactive protein inflammation status MELD score periapical radiolucency. Diseases of the digestive system. Gastroenterology RC799-869 |
| spellingShingle |
Apical periodontitis cirrhosis C-reactive protein inflammation status MELD score periapical radiolucency. Diseases of the digestive system. Gastroenterology RC799-869 Grønkjær LL Holmstrup P Schou S Schwartz K Kongstad J Jepsen P Vilstrup H Presence and consequence of tooth periapical radiolucency in patients with cirrhosis |
| description |
Lea Ladegaard Grønkjær,1 Palle Holmstrup,2 Søren Schou,3 Kristoffer Schwartz,4 Johanne Kongstad,2 Peter Jepsen,1,5 Hendrik Vilstrup1 1Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, 2Section of Periodontology, Microbiology, and Community Dentistry, Department of Odontology, Faculty of Health and Medical Sciences, 3Section for Oral and Maxillofacial Surgery, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 4Department of Oral and Maxillofacial Surgery, 5Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark Background: Periapical radiolucency is the radiographic sign of inflammatory bone lesions around the apex of the tooth. We determined the prevalence and predictors of periapical radiolucency in patients with cirrhosis and the association with systemic inflammation status and cirrhosis-related complications.Methods: A total of 110 cirrhosis patients were consecutively enrolled. Periapical radiolucency was defined as the presence of radiolucency or widening of the periapical periodontal ligament space to more than twice the normal width. Predictors of periapical radiolucency and the association with systemic inflammation markers and cirrhosis-related complications were explored by univariable and multivariable logistic regression analyses.Results: Periapical radiolucency was present in one or more teeth in 46% of the patients. Strong predictors were gross caries (odds ratio [OR] 3.12, 95% confidence interval [CI] 1.43–6.79) and severe periodontitis (OR 3.98, 95% CI 1.04–15.20). Also old age (OR 1.10, 95% CI 1.01–1.19) and smoking (OR 3.24, 95% CI 1.02–17.62) were predictors. However, cirrhosis etiology (alcoholic vs nonalcoholic) or severity (Model of End-Stage Liver Disease score) were not predictors. The patients with periapical radiolucency had higher C-reactive protein (15.8 mg/L vs 8.1 mg/L, P=0.02) and lower albumin contents (25 g/L vs 28 g/L, P=0.04) than those without. Furthermore, the patients with periapical radiolucency had a higher prevalence of cirrhosis-related complications such as ascites, hepatic encephalopathy, and/or variceal ­bleeding (46% vs 27%, P=0.05).Conclusion: Periapical radiolucency is often present as an element of poor oral health status and likely has an adverse clinical significance, which should motivate diagnostic and clinical attention to the findings. Keywords: apical periodontitis, cirrhosis, C-reactive protein, inflammation status, MELD score, periapical radiolucency |
| format |
article |
| author |
Grønkjær LL Holmstrup P Schou S Schwartz K Kongstad J Jepsen P Vilstrup H |
| author_facet |
Grønkjær LL Holmstrup P Schou S Schwartz K Kongstad J Jepsen P Vilstrup H |
| author_sort |
Grønkjær LL |
| title |
Presence and consequence of tooth periapical radiolucency in patients with cirrhosis |
| title_short |
Presence and consequence of tooth periapical radiolucency in patients with cirrhosis |
| title_full |
Presence and consequence of tooth periapical radiolucency in patients with cirrhosis |
| title_fullStr |
Presence and consequence of tooth periapical radiolucency in patients with cirrhosis |
| title_full_unstemmed |
Presence and consequence of tooth periapical radiolucency in patients with cirrhosis |
| title_sort |
presence and consequence of tooth periapical radiolucency in patients with cirrhosis |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/d46f28b7eda34f4eb21f5bdcb7605988 |
| work_keys_str_mv |
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1718400198618644480 |