Gut microbiota: sculptors of the intestinal stem cell niche in health and inflammatory bowel disease

Intestinal epithelium represents a dynamic and diverse cellular system that continuously interacts with gut commensals and external cues. Intestinal stem cells, which lie at the heart of epithelial renewal and turnover, proliferate to maintain a steady stem cell population and differentiate to form...

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Autores principales:	Manasvini Markandey, Aditya Bajaj, Nicholas Edward Ilott, Saurabh Kedia, Simon Travis, Fiona Powrie, Vineet Ahuja
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	intestinal epithelial stem cells (iscs) gut microbiota crypt specific core microbiota cscm) paneth cells enteroendocrine cells mesenchyme gut metabolites inflammatory bowel disease (ibd) Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/d46fa2cb0dd6400ba129951982702dda
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spelling	oai:doaj.org-article:d46fa2cb0dd6400ba129951982702dda2021-11-11T14:23:42ZGut microbiota: sculptors of the intestinal stem cell niche in health and inflammatory bowel disease1949-09761949-098410.1080/19490976.2021.1990827https://doaj.org/article/d46fa2cb0dd6400ba129951982702dda2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/19490976.2021.1990827https://doaj.org/toc/1949-0976https://doaj.org/toc/1949-0984Intestinal epithelium represents a dynamic and diverse cellular system that continuously interacts with gut commensals and external cues. Intestinal stem cells, which lie at the heart of epithelial renewal and turnover, proliferate to maintain a steady stem cell population and differentiate to form functional epithelial cell types. This rather sophisticated assembly-line is maintained by an elaborate micro-environment, sculpted by a myriad of host and gut microbiota-derived signals, forming an intestinal stem cell niche. This complex, yet crucial signaling niche undergoes dynamic changes during homeostasis and chronic intestinal inflammation. Inflammatory bowel disease refers to a chronic inflammatory response toward pathogenic or commensal microbiota, in a genetically susceptible host. Compositional and functional alterations in gut microbiota are pathognomonic of IBD. The present review highlights the modulatory role of gut microbiota on the intestinal stem cell niche during homeostasis and inflammatory bowel disease. We discuss the mechanisms of direct action of gut commensals (through microbiota-derived or microbiota-influenced metabolites) on ISCs, followed by their effects via other epithelial and immune cell types.Manasvini MarkandeyAditya BajajNicholas Edward IlottSaurabh KediaSimon TravisFiona PowrieVineet AhujaTaylor & Francis Grouparticleintestinal epithelial stem cells (iscs)gut microbiotacrypt specific core microbiota cscm)paneth cellsenteroendocrine cellsmesenchymegut metabolitesinflammatory bowel disease (ibd)Diseases of the digestive system. GastroenterologyRC799-869ENGut Microbes, Vol 13, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intestinal epithelial stem cells (iscs) gut microbiota crypt specific core microbiota cscm) paneth cells enteroendocrine cells mesenchyme gut metabolites inflammatory bowel disease (ibd) Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	intestinal epithelial stem cells (iscs) gut microbiota crypt specific core microbiota cscm) paneth cells enteroendocrine cells mesenchyme gut metabolites inflammatory bowel disease (ibd) Diseases of the digestive system. Gastroenterology RC799-869 Manasvini Markandey Aditya Bajaj Nicholas Edward Ilott Saurabh Kedia Simon Travis Fiona Powrie Vineet Ahuja Gut microbiota: sculptors of the intestinal stem cell niche in health and inflammatory bowel disease
description	Intestinal epithelium represents a dynamic and diverse cellular system that continuously interacts with gut commensals and external cues. Intestinal stem cells, which lie at the heart of epithelial renewal and turnover, proliferate to maintain a steady stem cell population and differentiate to form functional epithelial cell types. This rather sophisticated assembly-line is maintained by an elaborate micro-environment, sculpted by a myriad of host and gut microbiota-derived signals, forming an intestinal stem cell niche. This complex, yet crucial signaling niche undergoes dynamic changes during homeostasis and chronic intestinal inflammation. Inflammatory bowel disease refers to a chronic inflammatory response toward pathogenic or commensal microbiota, in a genetically susceptible host. Compositional and functional alterations in gut microbiota are pathognomonic of IBD. The present review highlights the modulatory role of gut microbiota on the intestinal stem cell niche during homeostasis and inflammatory bowel disease. We discuss the mechanisms of direct action of gut commensals (through microbiota-derived or microbiota-influenced metabolites) on ISCs, followed by their effects via other epithelial and immune cell types.
format	article
author	Manasvini Markandey Aditya Bajaj Nicholas Edward Ilott Saurabh Kedia Simon Travis Fiona Powrie Vineet Ahuja
author_facet	Manasvini Markandey Aditya Bajaj Nicholas Edward Ilott Saurabh Kedia Simon Travis Fiona Powrie Vineet Ahuja
author_sort	Manasvini Markandey
title	Gut microbiota: sculptors of the intestinal stem cell niche in health and inflammatory bowel disease
title_short	Gut microbiota: sculptors of the intestinal stem cell niche in health and inflammatory bowel disease
title_full	Gut microbiota: sculptors of the intestinal stem cell niche in health and inflammatory bowel disease
title_fullStr	Gut microbiota: sculptors of the intestinal stem cell niche in health and inflammatory bowel disease
title_full_unstemmed	Gut microbiota: sculptors of the intestinal stem cell niche in health and inflammatory bowel disease
title_sort	gut microbiota: sculptors of the intestinal stem cell niche in health and inflammatory bowel disease
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/d46fa2cb0dd6400ba129951982702dda
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Gut microbiota: sculptors of the intestinal stem cell niche in health and inflammatory bowel disease

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