SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion

Sustained Wnt secretion requires the endosomal SNX3-retromer complex for endosome-to-trans-Golgi network transport of the internalised Wnt chaperone Wntless. Here the authors show that in both C. elegans and human cells, SNX3-retromer requires an evolutionary conserved membrane remodelling complex f...

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Autores principales:	Ian J. McGough, Reinoud E. A. de Groot, Adam P. Jellett, Marco C. Betist, Katherine C. Varandas, Chris M. Danson, Kate J. Heesom, Hendrik C. Korswagen, Peter J. Cullen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d470221d33d847238609773f477f4c71
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spelling	oai:doaj.org-article:d470221d33d847238609773f477f4c712021-12-02T16:49:23ZSNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion10.1038/s41467-018-06114-32041-1723https://doaj.org/article/d470221d33d847238609773f477f4c712018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06114-3https://doaj.org/toc/2041-1723Sustained Wnt secretion requires the endosomal SNX3-retromer complex for endosome-to-trans-Golgi network transport of the internalised Wnt chaperone Wntless. Here the authors show that in both C. elegans and human cells, SNX3-retromer requires an evolutionary conserved membrane remodelling complex for Wntless sorting and Wnt secretion.Ian J. McGoughReinoud E. A. de GrootAdam P. JellettMarco C. BetistKatherine C. VarandasChris M. DansonKate J. HeesomHendrik C. KorswagenPeter J. CullenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ian J. McGough Reinoud E. A. de Groot Adam P. Jellett Marco C. Betist Katherine C. Varandas Chris M. Danson Kate J. Heesom Hendrik C. Korswagen Peter J. Cullen SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion
description	Sustained Wnt secretion requires the endosomal SNX3-retromer complex for endosome-to-trans-Golgi network transport of the internalised Wnt chaperone Wntless. Here the authors show that in both C. elegans and human cells, SNX3-retromer requires an evolutionary conserved membrane remodelling complex for Wntless sorting and Wnt secretion.
format	article
author	Ian J. McGough Reinoud E. A. de Groot Adam P. Jellett Marco C. Betist Katherine C. Varandas Chris M. Danson Kate J. Heesom Hendrik C. Korswagen Peter J. Cullen
author_facet	Ian J. McGough Reinoud E. A. de Groot Adam P. Jellett Marco C. Betist Katherine C. Varandas Chris M. Danson Kate J. Heesom Hendrik C. Korswagen Peter J. Cullen
author_sort	Ian J. McGough
title	SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion
title_short	SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion
title_full	SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion
title_fullStr	SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion
title_full_unstemmed	SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion
title_sort	snx3-retromer requires an evolutionary conserved mon2:dopey2:atp9a complex to mediate wntless sorting and wnt secretion
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d470221d33d847238609773f477f4c71
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SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion

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