The genomic landscape of pediatric myelodysplastic syndromes

Myelodysplastic syndromes (MDS) are uncommon in children and have poor prognosis. Here, the authors interrogate the genomic landscape of MDS, confirming adult and paediatric MDS are separate diseases with disparate mechanisms, and highlighting that SAMD9/SAMD9L mutations represent a new class of MDS...

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Autores principales:	Jason R. Schwartz, Jing Ma, Tamara Lamprecht, Michael Walsh, Shuoguo Wang, Victoria Bryant, Guangchun Song, Gang Wu, John Easton, Chimene Kesserwan, Kim E. Nichols, Charles G. Mullighan, Raul C. Ribeiro, Jeffery M. Klco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d4725852501c4cd68e3d57d74d9225b1
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spelling	oai:doaj.org-article:d4725852501c4cd68e3d57d74d9225b12021-12-02T14:42:43ZThe genomic landscape of pediatric myelodysplastic syndromes10.1038/s41467-017-01590-52041-1723https://doaj.org/article/d4725852501c4cd68e3d57d74d9225b12017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01590-5https://doaj.org/toc/2041-1723Myelodysplastic syndromes (MDS) are uncommon in children and have poor prognosis. Here, the authors interrogate the genomic landscape of MDS, confirming adult and paediatric MDS are separate diseases with disparate mechanisms, and highlighting that SAMD9/SAMD9L mutations represent a new class of MDS predisposition.Jason R. SchwartzJing MaTamara LamprechtMichael WalshShuoguo WangVictoria BryantGuangchun SongGang WuJohn EastonChimene KesserwanKim E. NicholsCharles G. MullighanRaul C. RibeiroJeffery M. KlcoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jason R. Schwartz Jing Ma Tamara Lamprecht Michael Walsh Shuoguo Wang Victoria Bryant Guangchun Song Gang Wu John Easton Chimene Kesserwan Kim E. Nichols Charles G. Mullighan Raul C. Ribeiro Jeffery M. Klco The genomic landscape of pediatric myelodysplastic syndromes
description	Myelodysplastic syndromes (MDS) are uncommon in children and have poor prognosis. Here, the authors interrogate the genomic landscape of MDS, confirming adult and paediatric MDS are separate diseases with disparate mechanisms, and highlighting that SAMD9/SAMD9L mutations represent a new class of MDS predisposition.
format	article
author	Jason R. Schwartz Jing Ma Tamara Lamprecht Michael Walsh Shuoguo Wang Victoria Bryant Guangchun Song Gang Wu John Easton Chimene Kesserwan Kim E. Nichols Charles G. Mullighan Raul C. Ribeiro Jeffery M. Klco
author_facet	Jason R. Schwartz Jing Ma Tamara Lamprecht Michael Walsh Shuoguo Wang Victoria Bryant Guangchun Song Gang Wu John Easton Chimene Kesserwan Kim E. Nichols Charles G. Mullighan Raul C. Ribeiro Jeffery M. Klco
author_sort	Jason R. Schwartz
title	The genomic landscape of pediatric myelodysplastic syndromes
title_short	The genomic landscape of pediatric myelodysplastic syndromes
title_full	The genomic landscape of pediatric myelodysplastic syndromes
title_fullStr	The genomic landscape of pediatric myelodysplastic syndromes
title_full_unstemmed	The genomic landscape of pediatric myelodysplastic syndromes
title_sort	genomic landscape of pediatric myelodysplastic syndromes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d4725852501c4cd68e3d57d74d9225b1
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The genomic landscape of pediatric myelodysplastic syndromes

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