PET/CT in therapy control of infective native aortic aneurysms

Abstract Infective native aortic aneurysms (INAA) are aneurysms arising from infection of the aortic wall. Treatment is demanding with 5-year survival rates between 53 and 55%. The aim of our study was to evaluate the usefulness of 18F-fluorodeoxyglucose positron emission tomography/computed tomogra...

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Autores principales:	Lars Husmann, Martin W. Huellner, Nadia Eberhard, Bruno Ledergerber, Marisa B. Kaelin, Alexia Anagnostopoulos, Ken Kudura, Irene A. Burger, Carlos-A. Mestres, Zoran Rancic, Barbara Hasse
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d472f95029e7459cba9b4a672d94ffda
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spelling	oai:doaj.org-article:d472f95029e7459cba9b4a672d94ffda2021-12-02T13:19:20ZPET/CT in therapy control of infective native aortic aneurysms10.1038/s41598-021-84658-z2045-2322https://doaj.org/article/d472f95029e7459cba9b4a672d94ffda2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84658-zhttps://doaj.org/toc/2045-2322Abstract Infective native aortic aneurysms (INAA) are aneurysms arising from infection of the aortic wall. Treatment is demanding with 5-year survival rates between 53 and 55%. The aim of our study was to evaluate the usefulness of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in the long-term monitoring of patients with proven INAA. Fifty-three PET/CT were performed in 15 patients with INAA in this single-center retrospective cohort study and retrospective analysis of prospectively collected Vascular Graft Cohort Study (VASGRA) data. Median metabolic activity (as measured by maximum standardized uptake value, SUVmax) of the aneurysms at the initial PET/CT was high (6.8 (IQR 5.7–21.8)), and lower at the last PET/CT prior to the end of antimicrobial therapy (3.9 (IQR 2.7–6.8); n = 11) as well as in the first PET/CT after the end of the treatment (3.9 (IQR 3.0–4.4);n = 6). Compared to the course of C-reactive protein alone, PET/CT provided different (> 20% difference in trend) or altering (opposed trend) information on the course of disease in at least 14 comparisons (56%) in 11 patients (73%). The one-year and five-year freedom from all-cause lethality was 92% (95% confidence interval 57%-99%). As compared to the course of C-reactive protein, PET/CT provides different and occasionally altering information in therapy control of INAA.Lars HusmannMartin W. HuellnerNadia EberhardBruno LedergerberMarisa B. KaelinAlexia AnagnostopoulosKen KuduraIrene A. BurgerCarlos-A. MestresZoran RancicBarbara HasseNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lars Husmann Martin W. Huellner Nadia Eberhard Bruno Ledergerber Marisa B. Kaelin Alexia Anagnostopoulos Ken Kudura Irene A. Burger Carlos-A. Mestres Zoran Rancic Barbara Hasse PET/CT in therapy control of infective native aortic aneurysms
description	Abstract Infective native aortic aneurysms (INAA) are aneurysms arising from infection of the aortic wall. Treatment is demanding with 5-year survival rates between 53 and 55%. The aim of our study was to evaluate the usefulness of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in the long-term monitoring of patients with proven INAA. Fifty-three PET/CT were performed in 15 patients with INAA in this single-center retrospective cohort study and retrospective analysis of prospectively collected Vascular Graft Cohort Study (VASGRA) data. Median metabolic activity (as measured by maximum standardized uptake value, SUVmax) of the aneurysms at the initial PET/CT was high (6.8 (IQR 5.7–21.8)), and lower at the last PET/CT prior to the end of antimicrobial therapy (3.9 (IQR 2.7–6.8); n = 11) as well as in the first PET/CT after the end of the treatment (3.9 (IQR 3.0–4.4);n = 6). Compared to the course of C-reactive protein alone, PET/CT provided different (> 20% difference in trend) or altering (opposed trend) information on the course of disease in at least 14 comparisons (56%) in 11 patients (73%). The one-year and five-year freedom from all-cause lethality was 92% (95% confidence interval 57%-99%). As compared to the course of C-reactive protein, PET/CT provides different and occasionally altering information in therapy control of INAA.
format	article
author	Lars Husmann Martin W. Huellner Nadia Eberhard Bruno Ledergerber Marisa B. Kaelin Alexia Anagnostopoulos Ken Kudura Irene A. Burger Carlos-A. Mestres Zoran Rancic Barbara Hasse
author_facet	Lars Husmann Martin W. Huellner Nadia Eberhard Bruno Ledergerber Marisa B. Kaelin Alexia Anagnostopoulos Ken Kudura Irene A. Burger Carlos-A. Mestres Zoran Rancic Barbara Hasse
author_sort	Lars Husmann
title	PET/CT in therapy control of infective native aortic aneurysms
title_short	PET/CT in therapy control of infective native aortic aneurysms
title_full	PET/CT in therapy control of infective native aortic aneurysms
title_fullStr	PET/CT in therapy control of infective native aortic aneurysms
title_full_unstemmed	PET/CT in therapy control of infective native aortic aneurysms
title_sort	pet/ct in therapy control of infective native aortic aneurysms
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d472f95029e7459cba9b4a672d94ffda
work_keys_str_mv	AT larshusmann petctintherapycontrolofinfectivenativeaorticaneurysms AT martinwhuellner petctintherapycontrolofinfectivenativeaorticaneurysms AT nadiaeberhard petctintherapycontrolofinfectivenativeaorticaneurysms AT brunoledergerber petctintherapycontrolofinfectivenativeaorticaneurysms AT marisabkaelin petctintherapycontrolofinfectivenativeaorticaneurysms AT alexiaanagnostopoulos petctintherapycontrolofinfectivenativeaorticaneurysms AT kenkudura petctintherapycontrolofinfectivenativeaorticaneurysms AT ireneaburger petctintherapycontrolofinfectivenativeaorticaneurysms AT carlosamestres petctintherapycontrolofinfectivenativeaorticaneurysms AT zoranrancic petctintherapycontrolofinfectivenativeaorticaneurysms AT barbarahasse petctintherapycontrolofinfectivenativeaorticaneurysms
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PET/CT in therapy control of infective native aortic aneurysms

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