Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis

Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis

Beige and brown fat may influence systemic metabolism through secreted signals. Here the authors identify a panel of metabolites secreted from beige and brown fat cells, which signal to influence fat tissue and skeletal muscle metabolism and have anti-obesity effects in mouse models of obesity and d...

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Main Authors: Anna Whitehead, Fynn N. Krause, Amy Moran, Amanda D. V. MacCannell, Jason L. Scragg, Ben D. McNally, Edward Boateng, Steven A. Murfitt, Samuel Virtue, John Wright, Jack Garnham, Graeme R. Davies, James Dodgson, Jurgen E. Schneider, Andrew J. Murray, Christopher Church, Antonio Vidal-Puig, Klaus K. Witte, Julian L. Griffin, Lee D. Roberts
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/d473c1c97b044c2fb72f34ce9316e47f
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Summary:Beige and brown fat may influence systemic metabolism through secreted signals. Here the authors identify a panel of metabolites secreted from beige and brown fat cells, which signal to influence fat tissue and skeletal muscle metabolism and have anti-obesity effects in mouse models of obesity and diabetes.

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