Adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers

Abstract The use of psychedelic substances at sub-sensorium ‘microdoses’, has gained popular academic interest for reported positive effects on wellness and cognition. The present study describes microdosing practices, motivations and mental health among a sample of self-selected microdosers (n = 40...

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Autores principales:	Joseph M. Rootman, Pamela Kryskow, Kalin Harvey, Paul Stamets, Eesmyal Santos-Brault, Kim P. C. Kuypers, Vince Polito, Francoise Bourzat, Zach Walsh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d474cc9ce9d34dcd99ae385f8e7d2834
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spelling	oai:doaj.org-article:d474cc9ce9d34dcd99ae385f8e7d28342021-11-21T12:18:44ZAdults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers10.1038/s41598-021-01811-42045-2322https://doaj.org/article/d474cc9ce9d34dcd99ae385f8e7d28342021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01811-4https://doaj.org/toc/2045-2322Abstract The use of psychedelic substances at sub-sensorium ‘microdoses’, has gained popular academic interest for reported positive effects on wellness and cognition. The present study describes microdosing practices, motivations and mental health among a sample of self-selected microdosers (n = 4050) and non-microdosers (n = 4653) via a mobile application. Psilocybin was the most commonly used microdose substances in our sample (85%) and we identified diverse microdose practices with regard to dosage, frequency, and the practice of stacking which involves combining psilocybin with non-psychedelic substances such as Lion’s Mane mushrooms, chocolate, and niacin. Microdosers were generally similar to non-microdosing controls with regard to demographics, but were more likely to report a history of mental health concerns. Among individuals reporting mental health concerns, microdosers exhibited lower levels of depression, anxiety, and stress across gender. Health and wellness-related motives were the most prominent motives across microdosers in general, and were more prominent among females and among individuals who reported mental health concerns. Our results indicate health and wellness motives and perceived mental health benefits among microdosers, and highlight the need for further research into the mental health consequences of microdosing including studies with rigorous longitudinal designs.Joseph M. RootmanPamela KryskowKalin HarveyPaul StametsEesmyal Santos-BraultKim P. C. KuypersVince PolitoFrancoise BourzatZach WalshNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joseph M. Rootman Pamela Kryskow Kalin Harvey Paul Stamets Eesmyal Santos-Brault Kim P. C. Kuypers Vince Polito Francoise Bourzat Zach Walsh Adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers
description	Abstract The use of psychedelic substances at sub-sensorium ‘microdoses’, has gained popular academic interest for reported positive effects on wellness and cognition. The present study describes microdosing practices, motivations and mental health among a sample of self-selected microdosers (n = 4050) and non-microdosers (n = 4653) via a mobile application. Psilocybin was the most commonly used microdose substances in our sample (85%) and we identified diverse microdose practices with regard to dosage, frequency, and the practice of stacking which involves combining psilocybin with non-psychedelic substances such as Lion’s Mane mushrooms, chocolate, and niacin. Microdosers were generally similar to non-microdosing controls with regard to demographics, but were more likely to report a history of mental health concerns. Among individuals reporting mental health concerns, microdosers exhibited lower levels of depression, anxiety, and stress across gender. Health and wellness-related motives were the most prominent motives across microdosers in general, and were more prominent among females and among individuals who reported mental health concerns. Our results indicate health and wellness motives and perceived mental health benefits among microdosers, and highlight the need for further research into the mental health consequences of microdosing including studies with rigorous longitudinal designs.
format	article
author	Joseph M. Rootman Pamela Kryskow Kalin Harvey Paul Stamets Eesmyal Santos-Brault Kim P. C. Kuypers Vince Polito Francoise Bourzat Zach Walsh
author_facet	Joseph M. Rootman Pamela Kryskow Kalin Harvey Paul Stamets Eesmyal Santos-Brault Kim P. C. Kuypers Vince Polito Francoise Bourzat Zach Walsh
author_sort	Joseph M. Rootman
title	Adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers
title_short	Adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers
title_full	Adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers
title_fullStr	Adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers
title_full_unstemmed	Adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers
title_sort	adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d474cc9ce9d34dcd99ae385f8e7d2834
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Adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers

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