Nickel-catalysed migratory hydroalkynylation and enantioselective hydroalkynylation of olefins with bromoalkynes

Chiral alkyne motifs bearing an α stereocentre are often found in many bioactive compounds, chemical probes, and functional materials. Here the authors show NiH-catalysed reductive migratory hydroalkynylation of olefins with bromoalkynes that form benzylic alkynylation products in high yield and wit...

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Auteurs principaux:	Xiaoli Jiang, Bo Han, Yuhang Xue, Mei Duan, Zhuofan Gui, You Wang, Shaolin Zhu
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/d475a7bcee6a4d10a8314b5ccc7f2df6
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spelling	oai:doaj.org-article:d475a7bcee6a4d10a8314b5ccc7f2df62021-12-02T17:40:24ZNickel-catalysed migratory hydroalkynylation and enantioselective hydroalkynylation of olefins with bromoalkynes10.1038/s41467-021-24094-92041-1723https://doaj.org/article/d475a7bcee6a4d10a8314b5ccc7f2df62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24094-9https://doaj.org/toc/2041-1723Chiral alkyne motifs bearing an α stereocentre are often found in many bioactive compounds, chemical probes, and functional materials. Here the authors show NiH-catalysed reductive migratory hydroalkynylation of olefins with bromoalkynes that form benzylic alkynylation products in high yield and with excellent regioselectivity.Xiaoli JiangBo HanYuhang XueMei DuanZhuofan GuiYou WangShaolin ZhuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoli Jiang Bo Han Yuhang Xue Mei Duan Zhuofan Gui You Wang Shaolin Zhu Nickel-catalysed migratory hydroalkynylation and enantioselective hydroalkynylation of olefins with bromoalkynes
description	Chiral alkyne motifs bearing an α stereocentre are often found in many bioactive compounds, chemical probes, and functional materials. Here the authors show NiH-catalysed reductive migratory hydroalkynylation of olefins with bromoalkynes that form benzylic alkynylation products in high yield and with excellent regioselectivity.
format	article
author	Xiaoli Jiang Bo Han Yuhang Xue Mei Duan Zhuofan Gui You Wang Shaolin Zhu
author_facet	Xiaoli Jiang Bo Han Yuhang Xue Mei Duan Zhuofan Gui You Wang Shaolin Zhu
author_sort	Xiaoli Jiang
title	Nickel-catalysed migratory hydroalkynylation and enantioselective hydroalkynylation of olefins with bromoalkynes
title_short	Nickel-catalysed migratory hydroalkynylation and enantioselective hydroalkynylation of olefins with bromoalkynes
title_full	Nickel-catalysed migratory hydroalkynylation and enantioselective hydroalkynylation of olefins with bromoalkynes
title_fullStr	Nickel-catalysed migratory hydroalkynylation and enantioselective hydroalkynylation of olefins with bromoalkynes
title_full_unstemmed	Nickel-catalysed migratory hydroalkynylation and enantioselective hydroalkynylation of olefins with bromoalkynes
title_sort	nickel-catalysed migratory hydroalkynylation and enantioselective hydroalkynylation of olefins with bromoalkynes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d475a7bcee6a4d10a8314b5ccc7f2df6
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Nickel-catalysed migratory hydroalkynylation and enantioselective hydroalkynylation of olefins with bromoalkynes

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