Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19

Background COVID-19 is characterized by the presence of oxidative stress. Vitamin D status has been reviewed as one of the factors that may affect disease severity. The aim of this study was to assess the relationship between serum vitamin D levels, oxidative stress markers and disease severity in h...

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Autores principales:	Emilija Atanasovska, Marija Petrusevska, Dragica Zendelovska, Katerina Spasovska, Milena Stevanovikj, Katerina Kasapinova, Kalina Gjorgjievska, Nikola Labachevski
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	covid-19 vitamin d oxidative stress plasma peroxides disease severity antioxidants inflammation Pathology RB1-214 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d4775f1d2b254896a1412678d76afce8
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spelling	oai:doaj.org-article:d4775f1d2b254896a1412678d76afce82021-11-04T15:00:41ZVitamin D levels and oxidative stress markers in patients hospitalized with COVID-191351-00021743-292810.1080/13510002.2021.1999126https://doaj.org/article/d4775f1d2b254896a1412678d76afce82021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13510002.2021.1999126https://doaj.org/toc/1351-0002https://doaj.org/toc/1743-2928Background COVID-19 is characterized by the presence of oxidative stress. Vitamin D status has been reviewed as one of the factors that may affect disease severity. The aim of this study was to assess the relationship between serum vitamin D levels, oxidative stress markers and disease severity in hospitalized COVID-19 patients. Methods Vitamin D levels were measured in 33 patients with COVID-19. The total antioxidant power and plasma peroxides were determined in serum. Results Severe COVID-19 patients have lower vitamin D levels (18.39 ± 2.29 ng/mL vs. 28.47 ± 3.05 ng/mL, p < .05) and higher oxidative stress compared to the moderate group. When divided according to serum vitamin D levels, significantly higher values of LDH (604.8 ± 76.98 IU/mL vs. 261.57 ± 47.33 IU/mL) and D-dimer (5978 ± 2028ng/mL vs. 977.7 ± 172 ng/mL) were obtained in the group with vitamin D below 30 ng/mL, followed with significantly higher levels of plasma peroxides (d-ROMs: 414.9 ± 15.82 U.Carr vs. 352.4 ± 18.77 U.Carr; p < .05) and oxidative stress index (OSI: 92.25 ± 6.60 vs. 51.89 ± 6.45; p < .001). Conclusion The presented data provide a justification to consider vitamin D as an important factor that could ameliorate disease severity through its anti-inflammatory and antioxidant effects.Emilija AtanasovskaMarija PetrusevskaDragica ZendelovskaKaterina SpasovskaMilena StevanovikjKaterina KasapinovaKalina GjorgjievskaNikola LabachevskiTaylor & Francis Grouparticlecovid-19vitamin doxidative stressplasma peroxidesdisease severityantioxidantsinflammationPathologyRB1-214Biology (General)QH301-705.5ENRedox Report, Vol 26, Iss 1, Pp 184-189 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 vitamin d oxidative stress plasma peroxides disease severity antioxidants inflammation Pathology RB1-214 Biology (General) QH301-705.5
spellingShingle	covid-19 vitamin d oxidative stress plasma peroxides disease severity antioxidants inflammation Pathology RB1-214 Biology (General) QH301-705.5 Emilija Atanasovska Marija Petrusevska Dragica Zendelovska Katerina Spasovska Milena Stevanovikj Katerina Kasapinova Kalina Gjorgjievska Nikola Labachevski Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19
description	Background COVID-19 is characterized by the presence of oxidative stress. Vitamin D status has been reviewed as one of the factors that may affect disease severity. The aim of this study was to assess the relationship between serum vitamin D levels, oxidative stress markers and disease severity in hospitalized COVID-19 patients. Methods Vitamin D levels were measured in 33 patients with COVID-19. The total antioxidant power and plasma peroxides were determined in serum. Results Severe COVID-19 patients have lower vitamin D levels (18.39 ± 2.29 ng/mL vs. 28.47 ± 3.05 ng/mL, p < .05) and higher oxidative stress compared to the moderate group. When divided according to serum vitamin D levels, significantly higher values of LDH (604.8 ± 76.98 IU/mL vs. 261.57 ± 47.33 IU/mL) and D-dimer (5978 ± 2028ng/mL vs. 977.7 ± 172 ng/mL) were obtained in the group with vitamin D below 30 ng/mL, followed with significantly higher levels of plasma peroxides (d-ROMs: 414.9 ± 15.82 U.Carr vs. 352.4 ± 18.77 U.Carr; p < .05) and oxidative stress index (OSI: 92.25 ± 6.60 vs. 51.89 ± 6.45; p < .001). Conclusion The presented data provide a justification to consider vitamin D as an important factor that could ameliorate disease severity through its anti-inflammatory and antioxidant effects.
format	article
author	Emilija Atanasovska Marija Petrusevska Dragica Zendelovska Katerina Spasovska Milena Stevanovikj Katerina Kasapinova Kalina Gjorgjievska Nikola Labachevski
author_facet	Emilija Atanasovska Marija Petrusevska Dragica Zendelovska Katerina Spasovska Milena Stevanovikj Katerina Kasapinova Kalina Gjorgjievska Nikola Labachevski
author_sort	Emilija Atanasovska
title	Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19
title_short	Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19
title_full	Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19
title_fullStr	Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19
title_full_unstemmed	Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19
title_sort	vitamin d levels and oxidative stress markers in patients hospitalized with covid-19
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/d4775f1d2b254896a1412678d76afce8
work_keys_str_mv	AT emilijaatanasovska vitamindlevelsandoxidativestressmarkersinpatientshospitalizedwithcovid19 AT marijapetrusevska vitamindlevelsandoxidativestressmarkersinpatientshospitalizedwithcovid19 AT dragicazendelovska vitamindlevelsandoxidativestressmarkersinpatientshospitalizedwithcovid19 AT katerinaspasovska vitamindlevelsandoxidativestressmarkersinpatientshospitalizedwithcovid19 AT milenastevanovikj vitamindlevelsandoxidativestressmarkersinpatientshospitalizedwithcovid19 AT katerinakasapinova vitamindlevelsandoxidativestressmarkersinpatientshospitalizedwithcovid19 AT kalinagjorgjievska vitamindlevelsandoxidativestressmarkersinpatientshospitalizedwithcovid19 AT nikolalabachevski vitamindlevelsandoxidativestressmarkersinpatientshospitalizedwithcovid19
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Vitamin D levels and oxidative stress markers in patients hospitalized with COVID-19

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