The structural basis of promiscuity in small multidrug resistance transporters

The structural basis of promiscuity in small multidrug resistance transporters

Gdx-Clo is a bacterial transporter from the small multidrug resistance (SMR) family. Here, the authors use solid supported membrane electrophysiology to characterize Gdx-Clo functionally and report crystal structures of Gdx-Clo which confirm the dual topology architecture and offer insight into subs...

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Autores principales: Ali A. Kermani, Christian B. Macdonald, Olive E. Burata, B. Ben Koff, Akiko Koide, Eric Denbaum, Shohei Koide, Randy B. Stockbridge
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/d4785d992fee4f28884dcfc5aaeb641b
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spelling oai:doaj.org-article:d4785d992fee4f28884dcfc5aaeb641b2021-12-02T16:50:04ZThe structural basis of promiscuity in small multidrug resistance transporters10.1038/s41467-020-19820-82041-1723https://doaj.org/article/d4785d992fee4f28884dcfc5aaeb641b2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19820-8https://doaj.org/toc/2041-1723Gdx-Clo is a bacterial transporter from the small multidrug resistance (SMR) family. Here, the authors use solid supported membrane electrophysiology to characterize Gdx-Clo functionally and report crystal structures of Gdx-Clo which confirm the dual topology architecture and offer insight into substrate binding and transport mechanism.Ali A. KermaniChristian B. MacdonaldOlive E. BurataB. Ben KoffAkiko KoideEric DenbaumShohei KoideRandy B. StockbridgeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ali A. Kermani
Christian B. Macdonald
Olive E. Burata
B. Ben Koff
Akiko Koide
Eric Denbaum
Shohei Koide
Randy B. Stockbridge
The structural basis of promiscuity in small multidrug resistance transporters
description Gdx-Clo is a bacterial transporter from the small multidrug resistance (SMR) family. Here, the authors use solid supported membrane electrophysiology to characterize Gdx-Clo functionally and report crystal structures of Gdx-Clo which confirm the dual topology architecture and offer insight into substrate binding and transport mechanism.
format article
author Ali A. Kermani
Christian B. Macdonald
Olive E. Burata
B. Ben Koff
Akiko Koide
Eric Denbaum
Shohei Koide
Randy B. Stockbridge
author_facet Ali A. Kermani
Christian B. Macdonald
Olive E. Burata
B. Ben Koff
Akiko Koide
Eric Denbaum
Shohei Koide
Randy B. Stockbridge
author_sort Ali A. Kermani
title The structural basis of promiscuity in small multidrug resistance transporters
title_short The structural basis of promiscuity in small multidrug resistance transporters
title_full The structural basis of promiscuity in small multidrug resistance transporters
title_fullStr The structural basis of promiscuity in small multidrug resistance transporters
title_full_unstemmed The structural basis of promiscuity in small multidrug resistance transporters
title_sort structural basis of promiscuity in small multidrug resistance transporters
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/d4785d992fee4f28884dcfc5aaeb641b
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